Protein Alignment baz and PARD3B

DIOPT Version :10

• Sequence 1: NP_001036283.1
• Gene: baz / 32703
• FlyBaseID: FBgn0000163
• Length: 1520
• Species: Drosophila melanogaster
• Sequence 2: XP_011508854.1
• Gene: PARD3B / 117583
• HGNCID: 14446
• Length: 1213
• Species: Homo sapiens
• Alignment Length: 1645
• Identity: 366/1645 - (22%)
• Similarity: 567/1645 - (34%)
• Gaps: 660/1645 - (40%)

  Fly    52 PSPSTYSCVKPDSWVTVTHLQ-TQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGA 115
            |..|.|....|..||.:.||: |..|||||||.:.||.:|:::::|.|::..|...:....|:.|
Human    40 PFHSKYISEGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPA 104

  Fly   116 SGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMA-GLGVGLMVRRSSDPNLLAS 179
            ...      |||.|.  |...|...........||||     |.| .||..|:|||||||
Human   105 DRQ------SPDAFE--TEVAAQLAAFKPIGGEIEVT-----PSALKLGTPLLVRRSSDP----- 151

  Fly   180 LKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGG 244
            :....::.:.||:.|   ||.|.:.:..|      |.|..||.:..:.::.:||
Human   152 VPGPPADTQPSASHP---GGQSLKLVVPD------STQNLEDREVLNGVQTELL----------- 196

  Fly   245 SSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSL 309
                                                                           :.
Human   197 ---------------------------------------------------------------TS 198

  Fly   310 PRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALP--DKEHGG--GLLVQHVEPGSRAE 370
            ||   .|:.|.....:: |..||        |.|||:..:|  ....|.  ||.::.:|..||::
Human   199 PR---TKDTLSDMTRTV-EISGE--------GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSK 251

  Fly   371 R-GRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEM--- 431
            | |....::.|::||.:.|:..|.:|.|:..|:|::|..:.:.|| ..:||.|...|.:..:
Human   252 REGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVL-PPQNREQYEKSVIGSLNIF 315

  Fly   432 --------------------VEVATVSPTRKPH----------------------AAPVGTSLQV 454
                                ::.|.::.|..|.                      ::|..:.|..
Human   316 GNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMG 380

  Fly   455 ANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVD 519
            ..:.|..:||:|.|||||.||||:|.|||:...|..||::|||||:||||:||||:.|||:|||:
Human   381 FGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 445

  Fly   520 GTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAA 584
            |..:||:||.::||:||....|.|..:|::||:
Human   446 GRDVTGRTQEELVAMLRSTKQGETASLVIARQE-------------------------------- 478

  Fly   585 PAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVH 649
                                        .||:....:......:|     |..:.|:||..||::
Human   479 ----------------------------GHFLPRELKGEPDCCAL-----SLETSEQLTFEIPLN 510

  Fly   650 DTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQL 714
            |:..||||||:||         ..|..:|:        |||||:|::||||||.:||||||||||
Human   511 DSGSAGLGVSLKG---------NKSRETGT--------DLGIFIKSIIHGGAAFKDGRLRMNDQL 558

  Fly   715 LSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILR--------SASSSDILDHSN 771
            ::|||.||.|::|.||||||||:| :..|...|.|.|::.|:..|        .|.|....::.
Human   559 IAVNGESLLGKSNHEAMETLRRSM-SMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENC- 621

  Fly   772 SHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWS 836
                               .|..::|..:|||
Human   622 -------------------QNAVTTSRRNDNS--------------------------------- 634

  Fly   837 NPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNW 901
              :|..|  |.||                  .|.:|:...||                   ||.|
Human   635 --ILHPL--GTCS------------------PQDKQKGLLLP-------------------NDGW 658

  Fly   902 SPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQGPPINTVPGT 966
            :.:::                  |.|||    ||
Human   659 AESEV------------------PPSPT----PH------------------------------- 670

  Fly   967 PSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERE 1031
                        |.|.|    |:|.:|            |.:.:|
Human   671 ------------SALGL----GLEDYS------------HSSGVD-------------------- 687

  Fly  1032 RRIQLTKSAVYGG----SIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQL 1092
                   ||||..    :..|:|   .:...:....|.:|:...:........||..::|:..:
Human   688 -------SAVYFPDQHINFRSVT---PARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSK- 741

  Fly  1093 GDLGPSLGMKKSSSLESLQTMVQELQMSD----EPRGHQALRAPRGRGREDSLRAAVVSEPDASK 1153
             |.||:||:|||||||||||.|.|::.:|    .||.|..    ||||..:|.|||:....|..:
Human   742 -DFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMV----RGRGCNESFRAAIDKSYDGPE 801

  Fly  1154 PRKTWLLEDGDHEGG-------FASQRNGPFQSSLN----------------DGKHGCKSSRAKK 1195
            ..:...|.|.....|       .|.|.|...:...|                .||...|..:.|:
Human   802 EIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKE 866

  Fly  1196 PS-------ILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQ-- 1251
            .:       ..:|.|.|.||||.::|.           ........|.....|::::.:::::
Human   867 ENEDPERKIKKKGFGAMLRFGKKKEDK-----------GGKAEQKGTLKHGGLREEELEKMKEER 920

  Fly  1252 ------HQQQQQ--------IPTAALAA---LERNGKPPAY-----------------QPPPPLP 1282
                  ||:.::        ..|.|:.:   ::.:...|.|                 .|.||..
Human   921 ERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRA 985

  Fly  1283 APNGVGSNGIHQNDIFNHRYQHYANYEDLHQQHQQHQISGGDSTTSISETLSESTLECMRQQVIR 1347
            .|.|...:|...:...:|....||.....:     |.:...||    ......||
Human   986 GPFGYPRDGHPLSPERDHLEGLYAKVNKPY-----HPLVPADS----GRPTGGST---------- 1031

  Fly  1348 QRIKVEAESRRHQHYHSQRSARSQDVSMHSTSSGSQ----------PGSLAQPQAQSNGVRPMSS 1402
            .||    :..|.::|    .||.:...::....|..          ||  ..|...::.:|
Human  1032 DRI----QKLRKEYY----QARREGFPLYEDDEGRARPSEYDLLWVPG--RGPDGNAHNLR---- 1082

  Fly  1403 YYEYETVQQQRVGSIKHSHSSSATSSSSSPIN--------------VPHWKAA-----AMNGY-S 1447
               :|.:::|        ::|......:.|::              :|::..|     ....| .
Human  1083 ---FEGMERQ--------YASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPR 1136

  Fly  1448 PASLN-------------SSARSRGPFVTQVTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQ 1499
            |..|.             .:.:.:|||      |:......|.|           |:.|.||...
Human  1137 PTELRVADLRYPQHYPPPPAPQHKGPF------RQDVPPSPPQH-----------QRMPAYQETG 1184

  Fly  1500 KMSGPSQYGSAAGSQPHASK 1519
            :   |...|.:....|:.::
Human  1185 R---PGPRGGSPDQYPYRTQ 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	Par3_HAL_N_term	<62..100	CDD:463446	18/38 (47%)
		PDZ1_PDZ3_bazooka-like	330..416	CDD:467154	27/90 (30%)
		PDZ2_Par3-like	459..551	CDD:467271	51/91 (56%)
		PDZ3_Par3-like	639..756	CDD:467272	58/116 (50%)
PARD3B	XP_011508854.1	Par3_HAL_N_term	<44..91	CDD:463446	19/46 (41%)
		PDZ1_Par3-like	205..302	CDD:467178	30/106 (28%)
		PDZ2_Par3-like	385..477	CDD:467271	51/91 (56%)
		PDZ3_Par3-like	500..599	CDD:467272	58/116 (50%)