DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Il16

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006229550.1	Gene:	Il16 / 116996	RGDID:	1583872	Length:	1425	Species:	Rattus norvegicus

Alignment Length:	1523	Identity:	297/1523 - (19%)
Similarity:	441/1523 - (28%)	Gaps:	544/1523 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 PGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTC------PRDLSTPHIEV----TSTTSGPM 159
            |.:|.|||........:...:|  ......|..|.|      |...:..|...    :|||..|.
  Rat    24 PVLPAGGGHHQYALWHIHRRTP--LLGCQGTAPPPCCSWHLLPGQANRTHAAAAKPSSSTTHRPR 86

  Fly   160 AGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPER-----------LFLDKAGGQ 213
            .|      .:......|.:||:.|          ||...|.|.:.           |...|....
  Rat    87 PG------EQERKKRGLTSSLRME----------PHSHSGKSRKSTKFRSISRSLILCNAKTSDD 135

  Fly   214 LSPQWEEDDDPSH----QLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWME 274
            .|...|:..||..    |.||...|.                        ||| |.|.:     |
  Rat   136 SSSPDEKYPDPFETSLCQDKEGFFHS------------------------SMQ-LADTS-----E 170

  Fly   275 AAEKLQNQP------PAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEM 333
            |.  |.|.|      .|.|....||....|.:...:..:|....||.|....:|..|
  Rat   171 AG--LSNIPDLALASEAAQLQAAGSDRGKHCRKMFFLKESSTTSSKEKAGKSEAQSS-------- 225

  Fly   334 LLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQE 398
                                       ..:.|.:..:|.|                 ...:.|..
  Rat   226 ---------------------------NFLFPKACHQRTR-----------------SNSTSVNP 246

  Fly   399 QLRRALESSELRVRVLRGDR-------NRR---QQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQ 453
            ...|.::....:......||       ||:   ||.|..|:     .|..|||....|.:|   |
  Rat   247 YSAREMDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYPVS-----GTARPTRSLSTAQLG---Q 303

  Fly   454 VANTRKLGRKIEIMLKKG-PNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLE 517
            ::...:......|:|.|| ..|||||:....:...|...||:|:|...|||..||||:.||.:||
  Rat   304 LSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILE 368

  Fly   518 VDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAA 582
            ::|..:.|.|..|.:...:....|.....|.:|                      ...||::  .
  Rat   369 LNGESIAGLTHQDALQKFKQAKKGLLTLTVRTR----------------------LTTPPSL--C 409

  Fly   583 AAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLP-----PSSNSWHSREEL 642
            :..:||:       .|||                  .|.:..:.||.|     |:|.:..::...
  Rat   410 SHLSPPL-------CRSL------------------SSSTCGAQDSSPFSLESPASPASTAKPNY 449

  Fly   643 TLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGR 707
            .:.:.|...::||:|:.:                 |...:.......|:|:..:..|..|..|||
  Rat   450 RIMVEVSLKKEAGVGLGI-----------------GLCSIPYFQCISGVFIHTLSPGSVAHLDGR 497

  Fly   708 LRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNS 772
            ||..|:::.:|...:......|....|...       .||.:.::|.|
  Rat   498 LRCGDEIVEINDSPVHCMTLNEVYTILSHC-------DPGPVPIIVSR----------------- 538

  Fly   773 HSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGG----GGSAGNEMN 833
                                                :..|:..||:......    |...|.|.:
  Rat   539 ------------------------------------HPDPQVSEQQLKEAVAQAVEGVKFGKERH 567

  Fly   834 RWSNPVLDRLTGGICSSNSAQPS---SQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYM 895
            :||...:.||.    ||...:|:   .::.|...||        ||.....|.||    ::|.||
  Rat   568 QWSLEGVKRLE----SSWHGRPTLEKEREKHSAPPH--------RRAQKIMVRSS----SDSSYM 616

  Fly   896 ATNDNWSP----AQMHLMTAHGNT---ALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAV 953
            :.:...||    |::......|:|   :|...::.|| .|.:|:|||
  Rat   617 SGSPGGSPCSAGAELQPSEGEGSTHSPSLPPGEEQEP-CPGVPSRPH------------------ 662

  Fly   954 GNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTY 1018
             .:.||:         |.:.:......|.|:.       |.:.|.|:..|.|.............
  Rat   663 -QESPPL---------SESLERDSHPPLKLKN-------SFEILVRKPTSTKPKPPPRKYFKNDS 710

  Fly  1019 QRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAA 1083
            :..||| ||:|:     :|..                     ||  |.....|.|.||....|..
  Rat   711 EPQKKL-EEKEK-----VTDP---------------------SG--HTLPTCSQETRELLPLLLQ 746

  Fly  1084 AEAEARDQLGDL---GPSLGMKKSSSLESLQTMVQELQMSDEPRGHQALRAPRGRGREDSL-RAA 1144
            .:...|......   ||:...:.|||.|.            |||...:...|...|:...| |.|
  Rat   747 EDTAGRTLCTAACCPGPAASTQTSSSTEG------------EPRRSASPETPASPGKHPLLKRQA 799

  Fly  1145 VVSEPDASKPRKTW--------------LLEDGDHEGGFASQRNGPFQSSLN----DGKHGCKSS 1191
            .:.....|.....|              :.|:..|.         |.|.:.:    ||..|....
  Rat   800 RMDYSFDSTTEDPWVRISDCIKNLFSPIMSENHSHM---------PLQPNASLGEEDGTQGHPEG 855

  Fly  1192 RAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQH-QQQ 1255
            ...|.....|...:|:          ..|...|...||     .|..|...:|..:.|:.. .:.
  Rat   856 GLSKMDTANGAPRIFK----------SADGSTVKKGPP-----VAPKPAWFRQSLKGLRNRVPET 905

  Fly  1256 QQIPTAALA----ALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLHQQHQ 1316
            ::.|..|.|    .:.|:...|..|          ..|:.|.|      |...:.|:.......:
  Rat   906 RRAPEVASAIQTTPVSRDASGPQSQ----------ASSSSIRQ------RISSFENFGSSQLPDR 954

  Fly  1317 QHQISGGDSTTSISETLSESTLECMRQQVIR------QRIKVEAESRRHQ-HYHSQRSARSQDVS 1374
                  |....|:..|..|:|....:|...|      |..||.|:.|:.: ...|.....|.:|.
  Rat   955 ------GVQRLSLQPTSGETTRLPGKQDEGRFSGLPAQGTKVTAKHRQTEVEPPSTTFPNSSEVG 1013

  Fly  1375 MHSTSSGSQPGSLAQPQA-----------------QSNGVR---------PMSSYYEYETVQQQR 1413
            ....|....||....|:|                 |..|.:         |::....|||.....
  Rat  1014 DPDMSESPPPGQRPNPKALSPDPLLRLLTTQTEDTQGPGFKMPSQRARSFPLTRTQSYETKLLDE 1078

  Fly  1414 VGSIKHSHSSSATS--------------------------SSSSPINVPHWKAAAMNGYSPA--- 1449
            ..|..:|.||..:|                          |..||.|    .:||..|:..|
  Rat  1079 KSSKLYSISSQLSSAVMKSLLCLPSSASCGQITCIPKERVSPKSPCN----NSAAAEGFGEAVAS 1139

  Fly  1450 ----SLNSSARSRGPFVTQVTIREQSSG 1473
                |||.|           .:||.|.|
  Rat  1140 DTGFSLNLS-----------ELREYSEG 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	16/78 (21%)
		PDZ_signaling	341..412	CDD:238492	5/70 (7%)
		CRS1_YhbY	<390..>436	CDD:294440	10/55 (18%)
		PDZ_signaling	462..548	CDD:238492	30/86 (35%)
		PDZ_signaling	<686..753	CDD:238492	15/66 (23%)
Il16	XP_006229550.1	PDZ_signaling	316..391	CDD:238492	29/74 (39%)
		PDZ_signaling	454..536	CDD:238492	20/105 (19%)
		PDZ_signaling	1207..1284	CDD:238492
		PDZ	1329..1413	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900