DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and PATJ

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens

Alignment Length:	1679	Identity:	316/1679 - (18%)
Similarity:	545/1679 - (32%)	Gaps:	563/1679 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVG---TGSPDIFRDPTNTEAPTCP 141
            |.||..:....|:.:|..     .|..:..|.....|.:|:|.   ..:|.:..:..|:......
Human    68 PSDCSANFDFSRKGLLVF-----TDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMA 127

  Fly   142 RDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLF 206
            :.....:|::...::|   |||..::..||.:   |..:.....:.:..:.|      |..:||
Human   128 QGRQIEYIDIERPSTG---GLGFSVVALRSQN---LGKVDIFVKDVQPGSVA------DRDQRL- 179

  Fly   207 LDKAGGQL-----SPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGD 266
              |...|:     :|.   |.:.|||....||.|                   .:|.|.:
Human   180 --KENDQILAINHTPL---DQNISHQQAIALLQQ-------------------TTGSLRL----- 215

  Fly   267 GNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDG 331
                  :.|.|.:               |.....:.:.:..:||             |::.....
Human   216 ------IVAREPV---------------HTKSSTSSSLNDTTLP-------------ETVCWGHV 246

  Fly   332 EMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAER-GRLRRDDRILEINGIKLIGLTESQ 395
            |.:.:||: ||.||...:..|.  .|::|:.:.||..|:| |||:..|.||:|.|..:.|:|..|
Human   247 EEVELIND-GSGLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQ 308

  Fly   396 VQEQLRRALESSELRVRVLR---GDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTS------ 451
            |.:.||..  .:.:|:.|.|   ||              :.|...:|...|.|.|...|
Human   309 VAQVLRNC--GNSVRMLVARDPAGD--------------ISVTPPAPAALPVALPTVASKGPGSD 357

  Fly   452 ------LQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLK 510
                  ..|...||.|:.:.|.:      :|:..|:....|.|   ||:|:|:|..||..:|.::
Human   358 SSLFETYNVELVRKDGQSLGIRI------VGYVGTSHTGEASG---IYVKSIIPGSAAYHNGHIQ 413

  Fly   511 PGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVA 575
            ..|:::.|||..:.|....|||.:||.  ||..|.:.:.|::..:..:........|..|.| :.
Human   414 VNDKIVAVDGVNIQGFANHDVVEVLRN--AGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP-LK 475

  Fly   576 PPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSE------SAASNDSL----- 629
            |||:                    ..|...:::.|     :|...|      ....||::
Human   476 PPAL--------------------FLTGAVETETN-----VDGEDEEIKERIDTLKNDNIQALEK 515

  Fly   630 ----PPS-SNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDL 689
                |.| .|...||.|..|. |.::...|.|...:         |..:.....|..|..|...|
Human   516 LEKVPDSPENELKSRWENLLG-PDYEVMVATLDTQI---------ADDAELQKYSKLLPIHTLRL 570

  Fly   690 GI---------FVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKH 745
            |:         ::.:::.||.....|.|:..|:||.|||:.|.|::..||:..|:..
Human   571 GVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEV-------- 627

  Fly   746 PGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYL 810
            |...||:..|::....:|.|           ....:..|......::|...:...|:.|...::
Human   628 PPPFTLVCCRRLFDDEASVD-----------EPRRTETSLPETEVDHNMDVNTEEDDDGELALW- 680

  Fly   811 SPEKR----EQRCNGGG-------------------------------GGGSAGNEMNRWSNPVL 840
            |||.:    .:.|.|.|                               ||...|:.:...:...|
Human   681 SPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745

  Fly   841 DRLT-------------G----GICSSNSAQPSSQQSHQQQPH----PSQQQQQQRRLPAAPVCS 884
            |..:             |    |||     :|..:.:.::..:    .|.:.:.:.......:.|
Human   746 DNTSLAEAVEILKAVPPGLVHLGIC-----KPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINS 805

  Fly   885 SAAL------RNESYYM-----------------------ATNDNWSPAQMH------LMTAHGN 914
            |..|      |:|.|:.                       .:.:.|   :||      |......
Human   806 SLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAW---EMHEFLTPRLQEMDEE 867

  Fly   915 TALLIEDDAE------------PMSPTLPARP--------------HDGQHCNTSSANPSQNLAV 953
            ..:|::::.|            |:|....|.|              ||.:...:..|...:.:..
Human   868 REILVDEEYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYS 932

  Fly   954 GNQGP----PIN---------TVPGTPSTSSN-----FDATYSSQLSLETNSGVEHFSRDALGRR 1000
            ....|    |.|         ::|..|||..|     ||...:.....:|:..:.....|..|..
Human   933 QEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPS 997

  Fly  1001 SISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKH 1065
            .:       :|.......:..:.|...:.:..|: ::|::.|.|.:.|               ::
Human   998 LL-------IDLPVVAQRREQEDLPLYQHQATRV-ISKASAYTGMLSS---------------RY 1039

  Fly  1066 AKTASSIEQRETQQQLAAAEAEARDQLGDLGP------------SLGMKKSSSLESLQTMVQELQ 1118
            |.....:.:||      ..|.|........||            |||:    |:...||:::.|:
Human  1040 ATDTCELPERE------EGEGEETPNFSHWGPPRIVEIFREPNVSLGI----SIVGGQTVIKRLK 1094

  Fly  1119 MSDEPRG---HQALR-APRGRGREDSLRAAVVSEPDASKPRKTWLLEDGD---HEGGFASQRNGP 1176
            ..:|.:|   .|.|. :|.|                     ||..|:.||   ...|...|
Human  1095 NGEELKGIFIKQVLEDSPAG---------------------KTNALKTGDKILEVSGVDLQ---- 1134

  Fly  1177 FQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTA--TSP 1239
                        .:|.::....::..|:             ||.....::|....|:...  .:.
Human  1135 ------------NASHSEAVEAIKNAGN-------------PVVFIVQSLSSTPRVIPNVHNKAN 1174

  Fly  1240 QLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHR--Y 1302
            ::...|.|..|:.::::| .||          ||..:.|||..|... .|:...:.|.|..:  .
Human  1175 KITGNQNQDTQEKKEKRQ-GTA----------PPPMKLPPPYKALTD-DSDENEEEDAFTDQKIR 1227

  Fly  1303 QHYANYE-DLHQQHQQHQISG----------------------------GDSTTSISETLSESTL 1338
            |.||:.. :||....:...:|                            .|....|.:.|.|
Human  1228 QRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLE--- 1289

  Fly  1339 ECMRQQVIRQR-------------IKVEAESRRHQHYHSQRSARSQDVSMHSTS-----SGSQPG 1385
              :..|::..|             .||:....|::...:|.:.....|...|.|     ||::|.
Human  1290 --INNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPI 1352

  Fly  1386 SLAQPQAQSNGVR--PMSSYYEYETVQQ-------------------QRVGSIKHSHSSSATSSS 1429
            |..:..:...|::  |.|..::.|.:.|                   ..|..:|.....:..|.|
Human  1353 SSEEDGSVEVGIKQLPESESFKLEDMSQVIGQGMVADQQKALEYPPDNAVSQMKQQKYPTKVSFS 1417

  Fly  1430 S-----SPINVPHWKAAAMNGY----SPASLNSSARSRGPFVT-QVTIREQSSG 1473
            |     :|.:..|...|...||    :|.|::.:.   .|.|. |..|.|.|.|
Human  1418 SQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPAT---CPIVPGQEMIIEISKG 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	19/96 (20%)
		PDZ_signaling	341..412	CDD:238492	26/71 (37%)
		CRS1_YhbY	<390..>436	CDD:294440	12/48 (25%)
		PDZ_signaling	462..548	CDD:238492	26/85 (31%)
		PDZ_signaling	<686..753	CDD:238492	20/75 (27%)
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492	24/130 (18%)
		PDZ_signaling	246..325	CDD:238492	29/83 (35%)
		PDZ_signaling	366..450	CDD:238492	30/94 (32%)
		PDZ_signaling	570..634	CDD:238492	19/71 (27%)
		PDZ	683..772	CDD:214570	13/93 (14%)
		PDZ_signaling	1066..1157	CDD:238492	24/144 (17%)
		PDZ	1236..1321	CDD:214570	11/89 (12%)
		PDZ	1459..1574	CDD:214570	5/10 (50%)
		PDZ_signaling	1586..1666	CDD:238492
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810