DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and pard3aa

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_017209426.2	Gene:	pard3aa / 101882925	ZFINID:	ZDB-GENE-170531-1	Length:	1313	Species:	Danio rerio

Alignment Length:	1610	Identity:	413/1610 - (25%)
Similarity:	596/1610 - (37%)	Gaps:	542/1610 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PDSWVTVTHLQ-TQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGS 125
            |..|:.|..|: ...||||.||.:.|||||:::::|.:::..     |..||||.| :||.||.|
Zfish    42 PGYWIQVHRLEHGDGGILDLDDVLCDVADDKDRLVAVYEEQD-----PHHGGDGTS-ASSTGTQS 100

  Fly   126 PDIFRDPTNTEAPTCPRDLSTPH-----IEVTSTTSGPMAGLGVGLMVRRSSDPNLL----ASLK 181
            |::|   |:||..:.......|:     ||||..|    ....:.|.|||||||.|:    |.|:
Zfish   101 PELF---TSTELNSSNLSAFQPYQTSSEIEVTPIT----LRTNMPLHVRRSSDPALVGLPEAQLQ 158

  Fly   182 AE----GSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSP--QWEEDDDP-SHQLKEQLLHQQQPH 239
            .|    .:..|||..|.......:.....|::.|..|..  ....|..| |.|.:.:
Zfish   159 PEEPSRNNRTRWSTTAGFLKTNTTSGTNSLERKGKNLEAYRSLPRDVTPWSTQFQRE-------- 215

  Fly   240 AANGGSS-SGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGA 303
              |..|| |.||....|                |:|..|:.:.....::|        .:|:||
Zfish   216 --NARSSLSANHPMVDR----------------WLERQEQDEEDEDEERT--------ENGRNG- 253

  Fly   304 YSSKSLPRESKRKEPLGQAYESIREKDGEMLL---IINEYGSPLGLTALPDKEHGG---GLLVQH 362
                       |.||:|:|...:.....:.||   .::..|.|||:..:|......   ||||:.
Zfish   254 -----------RIEPVGRADSCVEAASLDDLLKPVEVSNGGGPLGIHVVPFSARDRRTLGLLVKR 307

  Fly   363 VEPGSRAERGRL-RRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRV------------- 413
            :|.|.:|||..| :.:|.|:.||...|..:...|.|...|:|:.:..:...|
Zfish   308 LERGGKAERETLFQENDCIVRINNADLRNIRFEQAQNLFRQAMRTPRILFHVVPAGKKAQYEVLS 372

  Fly   414 ----------LRGDRNR------RQQRDSKVAEMVEVATVSPTRKP----------HAAPVGTSL 452
                      :.|||..      ..:|.||........|:..|..|          .:.|..|:.
Zfish   373 QNELGLQTGSVSGDRGSLVEGAFSPRRMSKAESTRGYPTLPNTANPLNQTQLDPIQPSRPTSTTS 437

  Fly   453 QVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLE 517
            .|..::|:|||..:.|:|||.|||||:|:||.|.|...|||:||||||||||:|||||.||||||
Zfish   438 SVGYSKKIGRKFSVQLRKGPEGLGFSITSRDVPIGTSAPIYVKNILPRGAAIQDGRLKAGDRLLE 502

  Fly   518 VDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAA 582
            |:|..:.||||.:|||:||....|.||.:::|||::               |..|..|
Zfish   503 VNGVDLNGKTQEEVVALLRSTAMGGTVGLLISRQED---------------AFLPREA------- 545

  Fly   583 AAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIP 647
                                 ::|..|                  .|.|..    :||.:|..||
Zfish   546 ---------------------KEQDDL------------------ILTPDG----TREFMTFEIP 567

  Fly   648 VHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMND 712
            ::|:..|||||||||......:|                 |||||||::|.||||.:|||||:||
Zfish   568 LNDSGSAGLGVSVKGNRAKESHA-----------------DLGIFVKSIITGGAACKDGRLRIND 615

  Fly   713 QLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSH 777
            ||::|||.||..:.|.|||||||::|.....|. |.|.|:|.|:|
Zfish   616 QLIAVNGESLLEKTNQEAMETLRKSMSIESNKR-GMIQLIVARRI-------------------- 659

  Fly   778 SNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDR 842
                                                       .|.|..|.|      |.||
Zfish   660 -------------------------------------------AGRGEESPG------SPPV--- 672

  Fly   843 LTGGICSSNSAQPSSQQSHQQQPHPSQQQQ-QQRRLPAAPVCSSAALRNESYYMATNDNWSPAQM 906
                              |.|.|....::: .|...|.:||............|..:...||.
Zfish   673 ------------------HLQSPRDEHERRISQSLYPESPVDKHTPRSTMKARMMGHFQLSPT-- 717

  Fly   907 HLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLA--VGNQGPPINTVPGTPST 969
              :....:..::||||..|:   ||||..|.   ::||::......  :.........:|.
Zfish   718 --VNMPQDDTVIIEDDRPPV---LPARLSDQ---SSSSSHDDMGFVTEISESWTRDVQIPD---- 770

  Fly   970 SSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRI 1034
                |:|.|..|.::    ::.|.|:..||:|:|||              |.|:
Zfish   771 ----DSTLSPDLDMD----MDMFQREGFGRQSMSEK--------------RTKQ----------- 802

  Fly  1035 QLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLG----DL 1095
                                        |........|:.|:::..          .||    |:
Zfish   803 ----------------------------YSDPTQLDIIQSRKSKSM----------DLGNSSRDV 829

  Fly  1096 GPSLGMKKSSSLESLQTMVQELQMS-DEPRGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWL 1159
            ||:||:|||||||||||.|.|:.:: |.|......|..|||...:|.|||:....|  ||....|
Zfish   830 GPALGLKKSSSLESLQTAVAEVTLNGDVPFHRPRPRIIRGRACNESFRAAIDKSYD--KPSVPAL 892

  Fly  1160 LEDGDHEG-------GFASQRNG-------------PFQSSLN------DGKHGCKSSRAKKPSI 1198
            ..|.|.||       ...|.|:|             |..:.:|      |.|...|.....|..:
Zfish   893 SPDEDDEGMETLEEDTEESSRSGHDSISTATDLTLPPSNTEINGERTKDDKKKDKKDKNKAKKGV 957

  Fly  1199 LRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAAL 1263
            |:|:|.||||||||||         ..:....|..|........:::.|:::..|::.|..|..|
Zfish   958 LKGLGDMFRFGKNRKD---------EKMERKGSSKSKMEEMTASEEEMQRMRLEQERIQAKTREL 1013

  Fly  1264 AALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLHQ---QHQQHQISG-GD 1324
            .  ||..|.                              :.||..:|..:   ..::|..:| |.
Zfish  1014 R--ERQAKE------------------------------REYAEIQDFSRPLSSDEEHTYAGIGS 1046

  Fly  1325 STTSISETLSES----------------TLECMRQQVIR----------------------QRIK 1351
            ..:|:..:|..|                .||.:..||.:                      ||::
Zfish  1047 LDSSLDSSLDLSLTPGQERPLGPREPPLALETLYAQVNKPRSNRTAPADSNRLAPSNHDRIQRLR 1111

  Fly  1352 VEAESRRHQH--------YHSQRSARSQ---------DVSMHSTSSGSQ-------PGSLAQPQA 1392
            .|.:..:|:.        |..|:..:.|         ....||.|...|       ..|..|.|.
Zfish  1112 QEFQQAKHEEEPDDRRRSYSFQQQQQQQPWANTGSYTPTGRHSVSLEVQVQKQREDRDSFTQAQR 1176

  Fly  1393 QSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMNGY-SPASLNSSAR 1456
            |.|.: |........||.|.....:........|:..:|..:: |..:...||| ||.....:||
Zfish  1177 QYNSL-PRQPRKNPSTVSQDSWEKVYPPGDVFQTAKENSRYSI-HQGSRTANGYLSPTPTGMNAR 1239

  Fly  1457 SRGPFVTQVTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQKMSGPSQ 1506
                    |.:..|       .||:|.|:::.|:.:....|:::...|:|
Zfish  1240 --------VLLETQ-------ELLRQEQRRKEQEAKTKLPTMEEKPTPNQ 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	44/117 (38%)
		PDZ_signaling	341..412	CDD:238492	24/74 (32%)
		CRS1_YhbY	<390..>436	CDD:294440	11/74 (15%)
		PDZ_signaling	462..548	CDD:238492	54/85 (64%)
		PDZ_signaling	<686..753	CDD:238492	39/66 (59%)
pard3aa	XP_017209426.2	DUF3534	1..147	CDD:314862	44/117 (38%)
		PDZ_signaling	274..349	CDD:238492	24/74 (32%)
		PDZ_signaling	449..533	CDD:238492	52/83 (63%)
		PDZ_signaling	568..656	CDD:238492	50/105 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387987at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010