DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and pdzk1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_031752326.1	Gene:	pdzk1 / 100145801	XenbaseID:	XB-GENE-1013787	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	629	Identity:	127/629 - (20%)
Similarity:	242/629 - (38%)	Gaps:	167/629 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 GLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRR 421
            |.||:.|||||.||:..|:..||::::||..:.....::|...::.:..:..|.|.......|.:
Frog    32 GHLVRSVEPGSSAEKAGLKDGDRVMKVNGKFVDDKEHAEVVALIKDSGTTVTLEVLDKTAYENTK 96

  Fly   422 QQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEI--MLKKGPNGLGFSVTTRDN 484
            ::.|:|.:.       .|.::|.|...|........:.|.|:..:  ::|:|.:..|||:.|...
Frog    97 KKEDNKNSN-------QPAKQPEAPQPGAQPLANGGKALKRRPRLCYLIKEGNSSYGFSLKTTKC 154

  Fly   485 PAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVS 549
            ..|    |::..::|.|.|.:.| :|..||::||:|..:...|...:..:|:  .:|..:..:||
Frog   155 ENG----IFLSALVPNGIAAKAG-VKDDDRIIEVNGKNVEDSTHDKLAKMLK--ESGGKIMFLVS 212

  Fly   550 --------RQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQ 606
                    :.|.:|..||:     |.|.:.||  .|..         :.::|.::....:..|::
Frog   213 DKATDEYFKSQTMAITADK-----ANVELLPS--KPRT---------VELKKDTNGYGFYLRQEK 261

  Fly   607 SQLNESQHF---IDAGSES-----------AASNDSLPPSSNSWHSR---------EELTLHIPV 648
               |...||   ||:||.:           .|.|.....:.:  |..         ::.||.|..
Frog   262 ---NRKGHFIMEIDSGSPAEKAKLQDYDRIVAVNGECVEAKD--HEEVVKVIQKGGDKTTLLIAD 321

  Fly   649 HDTEK--AGLGVS-------VKG--KTCSNLNASGSSA--------------------------- 675
            ..|::  :..|||       .:|  |:.|...|:.:.|
Frog   322 KKTDEMYSLAGVSPYLYLQETQGEIKSSSKEEATPAPAVVPSQTPTPTVAPAQPSAVEPKKPETP 386

  Fly   676 ----------------SSGSNGLMKHDGDL----GIFVKNVIHGGAASRDGRLRMNDQLLSVNGV 720
                            ..|:||...|...:    |:|:..|:.||:|...| ::.:|.|:.||||
Frog   387 AAPTGGQKHKPRLCKLQKGNNGYGFHLNAIKDTPGLFMNQVLKGGSADVAG-IKNDDVLVEVNGV 450

  Fly   721 SLRGQNNAEAMETLRRAMVNTPGKHPGTITLLV----------GRKILRSASSSDILDHSNSHSH 775
            ::..::..:.:..::..        .|.:||||          |:||..:||.:|.:...:..|.
Frog   451 NMEKESYEDVLIKIKET--------KGILTLLVASQEAYDYFKGQKIPITASLADPVSEVSPSSS 507

  Fly   776 SHSNSSGGSNSNGSGNNNNSSSN--------ASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEM 832
            :.:.:|..|.:..:.......||        ..|........|..||.:::            ||
Frog   508 AAAPASTASKARAAPEPAEVQSNQKPAEEPKEKDMEKEKEKELEKEKEKEK------------EM 560

  Fly   833 NRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRR 876
            .:.....:::....  .....:..|:|..:|:|....:|:.:::
Frog   561 EKEKEKEIEKEKEK--EKEKVEQKSEQKPEQKPEQKPEQKPEQK 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	17/54 (31%)
		CRS1_YhbY	<390..>436	CDD:294440	6/45 (13%)
		PDZ_signaling	462..548	CDD:238492	22/87 (25%)
		PDZ_signaling	<686..753	CDD:238492	16/70 (23%)
pdzk1	XP_031752326.1	PDZ_signaling	7..87	CDD:238492	17/54 (31%)
		PDZ_signaling	132..211	CDD:238492	21/85 (25%)
		PDZ_signaling	241..320	CDD:238492	15/92 (16%)
		gliding_GltJ	<348..>390	CDD:411345	3/41 (7%)
		PDZ	396..475	CDD:214570	20/87 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910