Protein Alignment CG5004 and PHLDB2

DIOPT Version :10

• Sequence 1: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Sequence 2: NP_001127910.1
• Gene: PHLDB2 / 90102
• HGNCID: 29573
• Length: 1253
• Species: Homo sapiens
• Alignment Length: 1452
• Identity: 310/1452 - (21%)
• Similarity: 486/1452 - (33%)
• Gaps: 521/1452 - (35%)

  Fly    91 LEETKL-------SQGAMITIGNSNY---LRFN-NPDEAQMMRSAMGSNERISMPQIDFTQSARQ 144
            |||..:       ||..|.::....|   |||. |.|.:       ||...:|.|    ..:.|.
Human    18 LEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYS-------GSYLTLSQP----VPAKRS 71

  Fly   145 AHELSQSLELESFYESIINPINNPSTYELECPKVFSSDLVTVNMPAKDVLGQKYASFARNLAENH 209
            ...|..|:.            ::||..:::..|.||.|....|:|.|.
Human    72 PSPLGTSVR------------SSPSLAKIQGSKQFSYDGTDKNIPMKP----------------- 107

  Fly   210 RNEKQLNNQYAKGVGSNGGYWNVPSNAAIYKEQHQQQHQQAPQDLLTKVNNDRYDRYPKAGGLQI 274
             ....||.     ..|..||   |...|.:.....:..::|.: |..|....:|....|:.. .:
Human   108 -PTPLLNT-----TSSLSGY---PLGRADFDHYTGRDSERALR-LSEKPPYSKYSSRHKSHD-NV 161

  Fly   275 YSMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSP---- 335
            ||:.|    :....|:|:......|:.|.|             :.|...:.|..:|:.|||
Human   162 YSLGG----LEGRKASGSLLAMWNGSSLSD-------------AGPPPISRSGAASMPSSPKQAR 209

  Fly   336 --IVQNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLS---SSSGYENV--------RL----- 382
              .:|:.:.....|.|.|.          .:|.||:|.:   |||...::        ||
Human   210 KMSIQDSLALQPKLTRHKE----------LASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATE 264

  Fly   383 -------------LGPNRVEINGQIHVPASAGDGG---SSSGVSSNALAPTAAVRASHENLNQNH 431
                         ||.::....|:..:|.|..|..   :.|.:||.||.             ...
Human   265 NQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALP-------------YKT 316

  Fly   432 SATTGGKY------VPQSPRTKIR------TNCMSPKKDVSFGNAFALAISPPP--LA--SSAVV 480
            ||:.|..|      ||.|||...:      ::|.|.    .|..|..:..:|..  ||  |..|.
Human   317 SASEGNPYVSSTLSVPASPRVARKMLLASTSSCASD----DFDQASYVGTNPSHSLLAGESDRVF 377

  Fly   481 STSK----------PIPIPSMVKPPLAPKPPAPNQQ------------RDYEQLFKSFERKQQQL 523
            :|.:          ...:.|:.:....|:|....::            .||.:..:....::|::
Human   378 ATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEM 442

  Fly   524 DRM----------------------------VPAKRSNKNINNLTL-NLQSV-ESQTQSP----- 553
            :|:                            ...::.||.:..|.| :.:|| |....||
Human   443 ERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYR 507

  Fly   554 ---KPSRKPAPAPRSIHLEQRQRRELIQRRKQLKRELAEL-----PPSAGI-------------- 596
               |.|...|.......|.|........|..:....|::|     |||:..
Human   508 CHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILP 572

  Fly   597 ---EGLELKLGEQPLAPSASPRL----QLQALQNRV-----------------CRL---EAQRNA 634
               ||:..:...|.||.....|:    .|:.|:.::                 |.|   |.:...
Human   573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637

  Fly   635 TRVMEE-------------------NQQAKLKQSIEIKQDQLKKLRAMLKQKPN--NAC------ 672
            |.:|:|                   .::.|.|..::.::::|::|:.:..::..  :.|
Human   638 TELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMRE 702

  Fly   673 -LKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRLMLE---------AELAA 727
             |:::|:...:.|:.:.|.|||||||..|.||......|...:|..|.:.|         .:::|
Human   703 QLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISA 767

  Fly   728 LRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAELLCPKRRNQEDLMSKSVNENMFYNHK 792
            |:.|                     .|.::.|:           :|.|:..:.:..|..|....:
Human   768 LKKQ---------------------ANHIVQQA-----------QREQDHFVKEKNNLIMMLQRE 800

  Fly   793 IEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDRFEVNP--LERRVPSQDDIDRSCKVANDA 855
            .|...:..|:     :..|:||.             .|.|||  |:....|.::|:..|
Human   801 KENLCNLEKK-----YSSLSGGK-------------GFPVNPNTLKEGYISVNEINEPC------ 841

  Fly   856 PISASQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLKKKSHDEARTQYLLSTQQSM 920
                  |.||.:..|                       .|...|....:.:.| |..|.|..||.
Human   842 ------GNSTNLSPS-----------------------TQFPADADAVATEPA-TAVLASQPQSK 876

  Fly   921 EQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNVQNRKSTGSSPTTTTT 985
            |..|.||.                :|...|.|..:.|.:.:           :|:|.|.....::
Human   877 EHFRSLEE----------------RKKQHKEGLYLSDTLPR-----------KKTTSSISPHFSS 914

  Fly   986 TTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGA--------------------GGANQMVAR 1030
            .|.|...||:..             |.:|...|.|:                    |..:|.::.
Human   915 ATMGRSITPKAH-------------LPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 966

  Fly  1031 SPRPLSEANNCDATIEAPKFANGM---DSSASPAVADN-KRASSNSQDTASAGSGSGNSGSGGST 1091
            ..|..||..|..|: |:..:.|..   |.|......|. ...||:|.:|:.:.....|..|..::
Human   967 GHRQKSEFYNRTAS-ESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS 1030

  Fly  1092 ------------------------------------------------------ASDRKRVLPK- 1101
                                                                  .|.|::::.|
Human  1031 NIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKE 1095

  Fly  1102 ---------HQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGATFHAW 1157
                     ..||||||||:...|.:||.|:|||||.||.|.||.:...:|||:|.|:|.....|
Human  1096 VKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTW 1160

  Fly  1158 SRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHL-NASKSGRPHCTFIVKTKKRSYN 1221
            .:||||.||.:....||:||.|.|.:|..||..|:|||.||| ||:||..|..||.|||..|.|.
Human  1161 KKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYY 1225

  Fly  1222 LQAASDSAARIWIDAIITGAQG 1243
            :.|.|..|.|||:|.|:|||:|
Human  1226 MVAPSPEAMRIWMDVIVTGAEG 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA_PHLB1	1..122	CDD:438765	12/41 (29%)
		SMC_N	<570..730	CDD:481474	46/242 (19%)
		Caldesmon	<664..801	CDD:460421	29/154 (19%)
		PH-like	1142..1242	CDD:473070	51/100 (51%)
PHLDB2	NP_001127910.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..159		26/141 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..212		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..286		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..567		8/41 (20%)
		sbcc	578..>1117	CDD:129705	117/665 (18%)
		Smc	<580..>802	CDD:440809	44/253 (17%)
		PH_PHLDB1_2	1142..1246	CDD:270192	51/103 (50%)