Protein Alignment CG5004 and Phldb2

DIOPT Version :10

• Sequence 1: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Sequence 2: XP_038944805.1
• Gene: Phldb2 / 685611
• RGDID: 1591402
• Length: 1358
• Species: Rattus norvegicus
• Alignment Length: 1463
• Identity: 313/1463 - (21%)
• Similarity: 515/1463 - (35%)
• Gaps: 442/1463 - (30%)

  Fly     4 TKKDPSLRVAA--SDPHLVSLGGGR---------LSTAVTIHYIHIGDTTIGSAASCSISLNGSG 57
            ||:.||...::  |.|.|..:.||:         :|....|.::           |.:.||:|..
  Rat   109 TKRSPSPLGSSVRSSPSLAKIQGGKQFCDGIDKNISMKPPISFL-----------SSTASLSGYP 162

  Fly    58 VRPLHCTIYRS-DANEVTLVPEK-------------DSRLLIDGAPILEETKLSQGAMITIGNSN 108
            :.......|.. |:.....:.||             ||...:.||    |.:.:.|:::|:.|.|
  Rat   163 IGKADLDHYTGRDSERSFRLSEKPPYSRYSSRNKSHDSVYFLGGA----EGRKASGSLLTMWNGN 223

  Fly   109 YLRFNNPDEAQMMRSAMGSNERISMPQIDFTQSARQAHE--LSQSLEL--------ESFYESII- 162
            .|  :....|.:.||...     |||     .|.:||.:  |..:|.|        |...|::.
  Rat   224 SL--SGTGSAPISRSGAA-----SMP-----SSPKQARKMNLQDNLPLQPRLSRHKEQASENVSV 276

  Fly   163 -------NPINNPSTYELECPKVF---SSDLVTVNMPAKDVLGQKYASFARNLAENHRNEKQLNN 217
                   :.::|...|....|:::   .:.:..:::|.::.||        |.......||.|.:
  Rat   277 RTRKYSGSSLSNMGAYSRSLPRLYKATDNQMSPLSLPPRNSLG--------NSRRGQLGEKDLPH 333

  Fly   218 QYAKGVGSNGGYWN---VPSNAAIYK------EQHQQQHQQAPQD-------LLTKVNNDRYDRY 266
            ...    .|..|.|   :.|.|:.||      ..:.......|..       ||...::|.:||.
  Rat   334 SLV----DNDNYLNFSSLSSGASPYKTCLSDGNPYVSSALSVPASPRVARKMLLASTSSDDFDRA 394

  Fly   267 PKAGGLQIYSMNGVNSDINNGP---ATGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSST 328
            ..:|....:|.      ::..|   .....:.:.|..||:|            :.:.|...
  Rat   395 SYSGTSPSHSF------LSGEPDRVLVARRNFSCGSMELDD------------SDLESLRQ---- 437

  Fly   329 SSITSSPIVQNRIKTNGSLP-----------------RDKNKSPFPQQAGVASSANISLLSSSSG 376
            ||.|..||::.|..:..|:.                 |::......:|   .....:||.:..:.
  Rat   438 SSETPQPILRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQ---RLETILSLCAEYTK 499

  Fly   377 YENVRLLGPNRVEINGQIHVPASAGDGGSSSGVSSNAL-APTAAVRASHENLNQN---------- 430
            .|..||.....|....:|:.............|...|| .|.|..|...:...|:
  Rat   500 PEGRRLSAGTTVADVQKINKELEKLQLSDEESVFEEALVCPDARYRCHRKGSLQDVDIAGFGSLG 564

  Fly   431 HSATTGGKYVPQSPRTKIRTNCMSPKKDVSFGNAFALAISPPPLASSAVVSTSKPIPIPSMVKPP 495
            |||:.      .:||        ..|.|...|:   |...|||.:::.:.:|::...:      .
  Rat   565 HSASF------LAPR--------GSKNDELLGD---LTRMPPPSSAAFLKATNESSYL------S 606

  Fly   496 LAPKPPAPNQQRDYEQLFKSFERKQQQLDRMVPAKRSNKNINNLTLNLQSVESQTQSPKPSRKPA 560
            :.||.|....:          |::.|:|..|..|:....|      ||:.:|.:.:....
  Rat   607 ILPKTPEDMGE----------EQRTQELAAMEDARMVILN------NLEELEQKIKDIND----- 650

  Fly   561 PAPRSIHLEQRQRRELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQALQNRV 625
                          ::.:..::|..|.|.|......|..|| :.|:.:         |..|..::
  Rat   651 --------------QMDESSRELDMECALLDGEQKSETAEL-MKEKEI---------LDHLNRKI 691

  Fly   626 CRLE----AQRNATRVMEENQQAKLKQSIEIKQDQLKKL----RAMLKQKPNNACLKEELQLVCE 682
            ..||    .::...:|..:.::.||::..|:..:|..:|    .||.:|      |:::|:...:
  Rat   692 TELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPEAMREQ------LQQQLKRDAD 750

  Fly   683 SLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGS 747
            .|:.:.|.|||||||..|.||......|...:|     |..|:|..:..|...:|:
  Rat   751 LLDVESKHFEDLEFQQLEHESRLDEEKENLTQQ-----LLREVAEYQRNIVARKEK--------- 801

  Fly   748 TGSNLVNGVMSQSLFGSAELLCPKRRNQEDLMSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLA 812
                 ::.:..|    ::.::...:|.|:..:.:..|..|....:.|...:..|:     :..|.
  Rat   802 -----ISALKKQ----ASHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK-----YSSLT 852

  Fly   813 GGSCEQISFNLSLQGDRFEVNP--LERRVPSQDDIDRSC---------------------KVAND 854
            ||.             .|.:||  |:....|.::|:.||                     :.|:.
  Rat   853 GGK-------------GFPINPNTLKEGYISVNEINESCGNSMNLSPSTQFPADADAAVTEPASA 904

  Fly   855 APISASQGAS------------TKIFDSIMEIERNRKLLLAQQGHQVIEHERQKMYD----LKKK 903
            .|:|..|.:.            :.:..|:.|...     .|.........:...:.|    |..|
  Rat   905 VPVSQPQSSEHQSAVCSGFMPPSTLSPSVTESSS-----AAWPEVMATPVDSFPLNDTPPPLPAK 964

  Fly   904 SHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKEN 968
            .|         ..||..|||.              |...|.:|...|.|..:.|.:.:
  Rat   965 KH---------RRQQPQEQQH--------------FRSLEERKKQHKEGLYLSDTLPR------- 999

  Fly   969 NVQNRKSTGSSPTTTTTTTTGGGTTPQQ-----QRHSQPELEHHAIALG---------IGGGGSG 1019
                :|:|.|.....::.|.|..|||:.     |.:|...:..|::|..         :.|..:.
  Rat  1000 ----KKTTPSLSPHFSSATMGRSTTPKAHLPLGQSNSCGSVLPHSLATMTKDAESRRILRGRMNS 1060

  Fly  1020 GAGGANQMVARSPRPLSEANNCDATIEAPKFANGM---DSSASPAVADN-KRASSNSQDTASAGS 1080
            .||..:|.::...|...|..:..|: |:..:.|..   |.|......|. ...||:|.:|:.:..
  Rat  1061 SAGYNHQQMSEGQRQKPEFYSRTAS-ESNVYLNSFHYSDRSYKDQAYDTLSLDSSDSMETSISAC 1124

  Fly  1081 GSGNSGSGGST------------------------------------------------------ 1091
            ...|..|..::
  Rat  1125 SPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEE 1189

  Fly  1092 ASDRKRVLPK----------HQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGY 1146
            .|.|::::.|          ..||||||||:...|.:||.|:|||||.||.|.||.:...:||||
  Rat  1190 TSQRQKLIEKEVKIREKQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCFHVSITEKTCRGY 1254

  Fly  1147 LHKLGATFHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHL-NASKSGRPHCT 1210
            |.|:|.....|.:||||.||.:....||:||.|.|.:|..||..|:|||.||| ||:||..|..|
  Rat  1255 LIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHEAKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1319

  Fly  1211 FIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243
            |.|||..|.|.:.|.|..|.|||:|.|:|||:|
  Rat  1320 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEG 1352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA_PHLB1	1..122	CDD:438765	30/142 (21%)
		SMC_N	<570..730	CDD:481474	40/167 (24%)
		Caldesmon	<664..801	CDD:460421	28/136 (21%)
		PH-like	1142..1242	CDD:473070	52/100 (52%)
Phldb2	XP_038944805.1	SMC_prok_B	<618..>841	CDD:274008	57/286 (20%)
		DUF5401	<1139..>1206	CDD:375164	3/66 (5%)
		PH_PHLDB1_2	1247..1351	CDD:270192	52/103 (50%)