DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5004 and PHLDB3

DIOPT Version :10

Sequence 1:NP_573195.1 Gene:CG5004 / 32698 FlyBaseID:FBgn0260748 Length:1247 Species:Drosophila melanogaster
Sequence 2:NP_942147.3 Gene:PHLDB3 / 653583 HGNCID:30499 Length:640 Species:Homo sapiens


Alignment Length:801 Identity:197/801 - (24%)
Similarity:285/801 - (35%) Gaps:226/801 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   494 PPLAPK----------PPAPNQQRDYEQLFKSFER--KQQQLDRMVPAKRSNKNINNLTLNLQSV 546
            |||.|:          |....:|...|.|.:...|  .:||.:.....:.|            |.
Human    13 PPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS------------ST 65

  Fly   547 ESQTQSPK---PSRKPAPAPRSI----------------HLEQRQRRELIQRR-KQLKRELAELP 591
            ||...:|:   |....|..|.|.                .||...|..|:::| |:|:|:..||.
Human    66 ESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELR 130

  Fly   592 PSAGIEGLELK---LGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVMEENQQAKLKQS---I 650
            ....:|...|:   .||:..|     |.:.:.|:..:.:..|.....|...|.:|.:|.|.   :
Human   131 IEMEVEVALLRGELAGERVAA-----RREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRL 190

  Fly   651 EIKQDQLKKLRAMLKQKPNN--ACLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFK 713
            |..:.:|:|.:..|..:|.:  ..|.:.:|.:.|.|:..::.:||||||..|.||          
Human   191 EGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERES---------- 245

  Fly   714 RQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAELLCPKRRNQEDL 778
            |||:.                |.:.||...                          |..:.||..
Human   246 RQEEE----------------DRDSPGPQV--------------------------PDPKVQELQ 268

  Fly   779 MSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDR---FEVNPLERRVP 840
            .|.:.:......|:|.......|.|..|:..:..|.|.::.....:|..:|   .|:|.|: ..|
Human   269 ASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQ-GTP 332

  Fly   841 SQDDIDRSCKVANDAPISASQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLKKKSH 905
            ..|             .|....|.||:   :...:.:|:||:.|              |....|.
Human   333 GGD-------------FSEPNPALTKL---LFTQKTDRQLLVLQ--------------DAVAHSA 367

  Fly   906 DEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNV 970
            ....:..|.|...|::....|:...:               |.:|.||                 
Human   368 ATPTSSCLFSVHSSLQGSIGLQRTGS---------------LPRKRGE----------------- 400

  Fly   971 QNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPL 1035
              |.|...||...:.             |....||..|:...:|..|.              .||
Human   401 --RGSQRGSPRPLSF-------------HCTESLEASALPPAVGDSGR--------------YPL 436

  Fly  1036 ------SEANNCDATIEAPKFANGMDSSASPAVADNKRASSNSQDTASAGSGSGNSGSGGSTASD 1094
                  ...|:|.|.  .|..|: |:.....|:|:.:|...     |..|:..|..||.|.    
Human   437 YQLLNCGRGNSCGAI--HPDIAH-MERLLQQAMAERERLLK-----AREGTRRGTEGSSGP---- 489

  Fly  1095 RKRVLPKHQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGATFHAWSR 1159
               .:|....|.|...|.....|:||.|:|..||..:.||||.|....|||.|.|:|.....|.:
Human   490 ---AVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRK 551

  Fly  1160 RWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHLN-ASKSGRPHCTFIVKTKKRSYNLQ 1223
            |||..|||...|.||:||.|.|.:|..||..|:|||.|||. |.||..|..||.|||.:|.:.:.
Human   552 RWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMV 616

  Fly  1224 AASDSAARIWIDAIITGAQGN 1244
            |.|..|.|||:|.|:|.|..|
Human   617 APSPEAMRIWMDVIVTAADEN 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5004NP_573195.1 FHA_PHLB1 1..122 CDD:438765
SMC_N <570..730 CDD:481474 42/168 (25%)
Caldesmon <664..801 CDD:460421 27/138 (20%)
PH-like 1142..1242 CDD:473070 49/100 (49%)
PHLDB3NP_942147.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 20/98 (20%)
SMC_prok_B <111..>322 CDD:274008 58/267 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..189 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..262 10/72 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..412 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..504 8/34 (24%)
PH_PHLDB1_2 535..635 CDD:270192 49/99 (49%)
Blue background indicates that the domain is not in the aligned region.

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