DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and PHLDB3

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_942147.3	Gene:	PHLDB3 / 653583	HGNCID:	30499	Length:	640	Species:	Homo sapiens

Alignment Length:	801	Identity:	197/801 - (24%)
Similarity:	285/801 - (35%)	Gaps:	226/801 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 PPLAPK----------PPAPNQQRDYEQLFKSFER--KQQQLDRMVPAKRSNKNINNLTLNLQSV 546
            |||.|:          |....:|...|.|.:...|  .:||.:.....:.|            |.
Human    13 PPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS------------ST 65

  Fly   547 ESQTQSPK---PSRKPAPAPRSI----------------HLEQRQRRELIQRR-KQLKRELAELP 591
            ||...:|:   |....|..|.|.                .||...|..|:::| |:|:|:..||.
Human    66 ESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELR 130

  Fly   592 PSAGIEGLELK---LGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVMEENQQAKLKQS---I 650
            ....:|...|:   .||:..|     |.:.:.|:..:.:..|.....|...|.:|.:|.|.   :
Human   131 IEMEVEVALLRGELAGERVAA-----RREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRL 190

  Fly   651 EIKQDQLKKLRAMLKQKPNN--ACLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFK 713
            |..:.:|:|.:..|..:|.:  ..|.:.:|.:.|.|:..::.:||||||..|.||
Human   191 EGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERES---------- 245

  Fly   714 RQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAELLCPKRRNQEDL 778
            |||:.                |.:.||...                          |..:.||..
Human   246 RQEEE----------------DRDSPGPQV--------------------------PDPKVQELQ 268

  Fly   779 MSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDR---FEVNPLERRVP 840
            .|.:.:......|:|.......|.|..|:..:..|.|.::.....:|..:|   .|:|.|: ..|
Human   269 ASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQ-GTP 332

  Fly   841 SQDDIDRSCKVANDAPISASQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLKKKSH 905
            ..|             .|....|.||:   :...:.:|:||:.|              |....|.
Human   333 GGD-------------FSEPNPALTKL---LFTQKTDRQLLVLQ--------------DAVAHSA 367

  Fly   906 DEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNV 970
            ....:..|.|...|::....|:...:               |.:|.||
Human   368 ATPTSSCLFSVHSSLQGSIGLQRTGS---------------LPRKRGE----------------- 400

  Fly   971 QNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPL 1035
              |.|...||...:.             |....||..|:...:|..|.              .||
Human   401 --RGSQRGSPRPLSF-------------HCTESLEASALPPAVGDSGR--------------YPL 436

  Fly  1036 ------SEANNCDATIEAPKFANGMDSSASPAVADNKRASSNSQDTASAGSGSGNSGSGGSTASD 1094
                  ...|:|.|.  .|..|: |:.....|:|:.:|...     |..|:..|..||.|.
Human   437 YQLLNCGRGNSCGAI--HPDIAH-MERLLQQAMAERERLLK-----AREGTRRGTEGSSGP---- 489

  Fly  1095 RKRVLPKHQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGATFHAWSR 1159
               .:|....|.|...|.....|:||.|:|..||..:.||||.|....|||.|.|:|.....|.:
Human   490 ---AVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRK 551

  Fly  1160 RWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHLN-ASKSGRPHCTFIVKTKKRSYNLQ 1223
            |||..|||...|.||:||.|.|.:|..||..|:|||.|||. |.||..|..||.|||.:|.:.:.
Human   552 RWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMV 616

  Fly  1224 AASDSAARIWIDAIITGAQGN 1244
            |.|..|.|||:|.|:|.|..|
Human   617 APSPEAMRIWMDVIVTAADEN 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622	49/100 (49%)
		PH	1143..1237	CDD:278594	47/94 (50%)
PHLDB3	NP_942147.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..100		20/98 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..189		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..262		10/72 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..412		9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..504		8/34 (24%)
		PH_PHLDB1_2	535..635	CDD:270192	49/99 (49%)
		PH	535..630	CDD:278594	47/94 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I7016
eggNOG	1	0.900	-	-		E1_2C17U
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45023at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40977
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12156
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5713
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.040