Protein Alignment CG5004 and phldb1b

DIOPT Version :10

• Sequence 1: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Sequence 2: XP_073779626.1
• Gene: phldb1b / 570275
• ZFINID: ZDB-GENE-121114-8
• Length: 1595
• Species: Danio rerio
• Alignment Length: 1662
• Identity: 382/1662 - (22%)
• Similarity: 600/1662 - (36%)
• Gaps: 546/1662 - (32%)

  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTI 65
            :.|.:...:|:|.|..|||||||.||||||:|:..:..|.||:|..| ..||:.|.||...||.|
Zfish    55 LDLIETGKALKVQAERPHLVSLGSGRLSTAITLLPLPEGKTTVGHGA-MDISIQGPGVAAQHCFI 118

  Fly    66 YRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAMG---- 126
             .:.|..:||.| ..::..:||.|:.:..:||||.|:..|.|.:.|||:|:||..|:|.|.
Zfish   119 -ENRAGIITLHP-CGNQCSMDGLPVNKPVRLSQGCMLCFGQSAFFRFNHPEEAFRMKSMMPEGGQ 181

  Fly   127 ------------------------------SNERISMPQIDFTQSARQAHE-LSQSLE--LESFY 158
                                          ||||:           |..|. :..|:|  |:...
Zfish   182 TASVKNWTHKDSENLVNGNHSSGEAKSHLVSNERV-----------RPEHSAIVSSIEKDLQDIM 235

  Fly   159 ESIINPINNPSTYELECPKVFSSDLVT-------VNMPAKDVLGQKYASFARNLAENHRNEK-QL 215
            :|::.....||:.|.:.|   ||..::       :|...:.:|....:..|.::..::.|.. ..
Zfish   236 DSLVMDDPQPSSSESKKP---SSQSISQSPLSPMLNGGGRFLLSPPTSPGAMSVGSSYENNSPPF 297

  Fly   216 NNQYAKGVGSNGGYWN---------------VPSNAAIYKEQHQQQHQQAPQDLLTKVNN-DRYD 264
            :...:....|:|.|..               ||..::.|....|....| |:.:|...:: ....
Zfish   298 SPLSSPSAASSGSYTTLSPIGCQDQPHMLPPVPVRSSSYNYTSQPPIPQ-PRTILPSYSSGSSGP 361

  Fly   265 RYPKAGGLQIY-----------SMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNS 318
            :.|::..||..           |..|:|.|.:......:...|    .:...:.|.|...|
Zfish   362 KVPESPRLQRKALLEAPPSPKPSRRGLNQDSSVAKTPDSPIQT----HILPSVSISTAPTD---- 418

  Fly   319 MPSTHNVS-----------STSSITSSPIVQNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLS 372
            :||...|.           ||:|..:|| ...|.||...| :|:..|||.:|    ...:.||.|
Zfish   419 VPSVSRVPVPGSPRLATKFSTASSPASP-SSPRTKTTIVL-QDRPSSPFREQ----PQPDRSLTS 477

  Fly   373 SSSGYENVRLLGPNR---VEINGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNH--- 431
            |.|.    :|..|:|   ..::..:|:..     |..|......|.|..:.|.:..||..:.
Zfish   478 SPSH----QLSPPSRSFQPPLDPIVHIIQ-----GGPSHPHPRTLQPPESPRLARRNLEGSSMRE 533

  Fly   432 -----------------SATTG---------GKYVPQSPRTK---------------IRTNCMSP 455
                             .|..|         .:.||:|||.:               :||...||
Zfish   534 LPPLSPSIARRGVPVLPGALPGTLRTPESPSPRMVPESPRLRRKTGSPTEEPFSPRAMRTRSPSP 598

  Fly   456 KKDV---------SFGNAFALAISPPPLASSAVVSTSKP------------IPIPSMVKPPLAPK 499
            ...:         ||||:.:.|.|...|..|:..|:.:.            :|.|.|.:...:..
Zfish   599 TSGLTGESSGRKGSFGNSLSSAFSLSSLPGSSPRSSPRSHRKMSAGHRDLRMPHPGMRERKNSIT 663

  Fly   500 PPAPN------------QQRDYEQLFKSFERKQQQ------------------LDRM-------- 526
            ..:.|            ::|..||..:..||::.:                  |.||
Zfish   664 EISDNEDDLLEYHRRQREERLREQEMERLERQRLETILNLCAEYNKGDGPPGDLGRMGVSGLGSR 728

  Fly   527 --VPAKR-SNKNINNLTL------------NLQSVESQTQSPK-PSRKPA-------PAPRSI-- 566
              :..:| |..::|:.:|            ||:...|.|:|.: ..|.||       .|..|:
Zfish   729 DGLNVRRPSMDSVNSASLRATQRQRESQEDNLKEDSSSTESAQLDGRTPALLNGQNGQAEESLGS 793

  Fly   567 ---------HLEQRQRR------ELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRL 616
                     :||:.:.|      ||..|..:|:::|.|....|.:|...|:...|..........
Zfish   794 GSIGRLELGYLEEERVRVLAKVDELKARITELEQQLQESKQEAEMERALLQGERQAEMEQIETET 858

  Fly   617 Q-LQALQNRVCRLEAQRNATRVMEENQQAKLKQSIEIKQDQLKKLRAMLKQKPNN--ACLKEELQ 678
            : :..||.::..||:.....:..|.......::::|..||...:|.:.|...|.:  ..|:|:|:
Zfish   859 EIINQLQRKLTELESSIQREKDKERANVDAEREALERLQDGYNELTSQLHNCPESLREQLQEQLK 923

  Fly   679 LVCESLESDRKTFEDLEFQYFEEES------------------EHHASHEEFKRQEQRLMLEAEL 725
            ...|:||:..|.|||||||..|.||                  ::|:|  ..||:|:.:.||::.
Zfish   924 REAETLEAATKQFEDLEFQQLERESSLEEERETISQQLMQDRAQYHSS--VAKRKEKVVALESQA 986

  Fly   726 AALRIQ----------------------------------------------------------- 731
            :.|.||
Zfish   987 SQLGIQAAQECERLAKDRTITLQMLHKEKERLASLERRYQSLTGGKTFPKSSNTIKEEYLKLSDV 1051

  Fly   732 ------------------------IGPDEEEP--------------------GSPTSPGST---- 748
                                    :.|.|..|                    .|||||..:
Zfish  1052 YKMYGSECHDIQLASASSHGLSLALDPAETAPREEYVTVGQLNQMYGMPKVESSPTSPVQSVQPS 1116

  Fly   749 -----------GSNLVNGVMSQSLFGSAEL--LCPKRRNQEDLMSKSVNE--------NMFYNHK 792
                       ||:|......||.:|..::  |..:...||.:.:..||:        ..|
Zfish  1117 LADFPRLPSPHGSSLSLSFERQSDWGRPQMPVLDLEHWYQEVMAAGDVNQLCPPPLPAKAF---- 1177

  Fly   793 IEANTSTPKRLPLQLFEDLAGGSCEQ------ISFNLSLQGDRFEVNPLERRVPSQDDIDRSCKV 851
             .:::|:|:| |:|::.......|.|      :|..||   ..:....|.|..||:..:    .|
Zfish  1178 -SSSSSSPRR-PVQVYRSRLDSDCSQSLLRPKVSAGLS---PTYTTATLGRNTPSRSPL----MV 1233

  Fly   852 ANDAPISASQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLKKKSHDEARTQYLLST 916
            ||.........|:|     :.:||..|:|.|.|:|.||||.:|:::.:||:|:..||:.|:
Zfish  1234 ANSTGSLPRNLAAT-----LQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAVEAQCQW---- 1289

  Fly   917 QQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQV----QKIAGDKENNVQNRKSTG 977
                        :|..|...:|.     |..:..|...:...:    ....|::..:..:.:|:.
Zfish  1290 ------------EALHGSQTQLH-----QPFSSSPAPALHHSILHHTAPPCGEQPYDTLSLESSD 1337

  Fly   978 SSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPLSEANNCD 1042
            |..|:.:|                                     |.|.  |.||..:|.|:..|
Zfish  1338 SMDTSIST-------------------------------------GNNS--ACSPDNMSSASGMD 1363

  Fly  1043 A-TIEAPKFANGMDSSASPAVADNKR-ASSNSQDTASAGSGSGNSGSGGSTASDR--KRVLPKHQ 1103
            | .||.      |:.....|..:..| ..|..::|.|..............|..|  :..|.:.|
Zfish  1364 ALKIEE------MEKMLKEAQLEKARLIESRERETQSRKLMLEEERRRREEAEKRLQEETLHRQQ 1422

  Fly  1104 ----------------RPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGA 1152
                            ||:||||||...:.:||.|||::||.:|.|.||.:....|:|:|.|:|.
Zfish  1423 LIEKEVKMRARNFSQARPMTRYLPIRKEEFDLRSHIESSGHSVDTCYHVILTEKMCKGFLVKMGG 1487

  Fly  1153 TFHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDH-----------LNASKSGR 1206
            ...:|.:||||.||.:....||:||.|.|.:|..||..|:|||.||           ||.:.|..
Zfish  1488 KIKSWKKRWFVFDRLKRTFSYYADKHESKLKGVIYFQAIEEVYYDHLRSATKKGFFNLNLTNSPT 1552

  Fly  1207 PHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243
            |..||.|||..|.|.:.|.|..|.|||:|.|:|||:|
Zfish  1553 PTLTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEG 1589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA_PHLB1	1..122	CDD:438765	51/120 (43%)
		SMC_N	<570..730	CDD:481474	47/186 (25%)
		Caldesmon	<664..801	CDD:460421	50/284 (18%)
		PH-like	1142..1242	CDD:473070	48/110 (44%)
phldb1b	XP_073779626.1	None