DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5004 and phldb1a

DIOPT Version :9

Sequence 1:NP_573195.1 Gene:CG5004 / 32698 FlyBaseID:FBgn0260748 Length:1247 Species:Drosophila melanogaster
Sequence 2:XP_694648.5 Gene:phldb1a / 566287 ZFINID:ZDB-GENE-060526-272 Length:1425 Species:Danio rerio


Alignment Length:1541 Identity:361/1541 - (23%)
Similarity:572/1541 - (37%) Gaps:458/1541 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTI 65
            :.|.:...:|:|.|..|||||||.||||||:|:..:..|.||:|. .:..|::.|.||...||.|
Zfish    39 LDLIETGKTLKVQAERPHLVSLGSGRLSTAITLLPLPEGKTTLGH-GNTDINIQGPGVMSQHCYI 102

  Fly    66 YRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAM--GS- 127
            ....| .:||.| ..::..:||..:.:..:|:||.|:..|.|::.|||:|:||..|:|.|  || 
Zfish   103 ENVGA-VITLYP-CGNQCSMDGLAVTKPVRLAQGCMLCFGQSSFFRFNHPEEALRMKSLMPGGSP 165

  Fly   128 -----------------------NER----------------------ISMP--QIDFTQSARQA 145
                                   :||                      :||.  |.:..:.||  
Zfish   166 GFTNTYKNHSETHGQLNGNHLPLHERSRPGAGTLVRSIEKDFQDIMNSLSMDDGQAEHCKKAR-- 228

  Fly   146 HELSQSLELESFYESIINPINNP------STYELECPKVFSSDLVTVNMPAK-----DVLGQKYA 199
            |.:.||..|.....|:::...:|      |:||...|..  |.|.|.:|.:.     |....:..
Zfish   229 HPIPQSAMLNGSSRSLVSTPTSPGALSVSSSYENTSPPY--SPLSTPSMVSSPGACLDSANTRSN 291

  Fly   200 SFARNLAENHRNEKQLNNQYAKGVGSNGGYWNVPSNAAIYKEQHQQQHQQAPQDLLTKVNNDRYD 264
            |:...:   .....|..|..:|...||||          .|:|...:.|:|    ||:..     
Zfish   292 SYTHTV---QAPVPQPRNFTSKNCSSNGG----------LKDQESARIQKA----LTETP----- 334

  Fly   265 RYPKAGGLQIYSMNGVN--SDINNGPATGNNSGTGG-GAELEDMLKICTEYADRNNSMPSTHNVS 326
                       |..|.|  .|..:|..:|::...|. |.::             |....|:.:.|
Zfish   335 -----------SSPGANRRGDNTHGSTSGSSLVPGDLGRQV-------------NTRFTSSSSAS 375

  Fly   327 ST--SSITSSPIVQNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVE 389
            |:  |||.||  ||....:..||.|.......||      |:..|:.:||     :|.|.|    
Zfish   376 SSPRSSIGSS--VQESSSSIQSLSRALLPPDSPQ------SSRRSVETSS-----IRELPP---- 423

  Fly   390 INGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTKIRTNCMS 454
                      .....|..|:....:.|.|.         .:.|.::.|:.||.|||.:.||..  
Zfish   424 ----------LSPSTSRRGILGVPVLPVAL---------PSVSLSSRGRTVPDSPRLQRRTTA-- 467

  Fly   455 PKKDVSFGNAFALAISPPPLA---------------SSAVVSTSKPIPIPSMVKPPLAPK----- 499
               :...||......||.|::               ||||.|.:...|:.|......|.:     
Zfish   468 ---EEEVGNTRLHTRSPSPVSTLLKDQSGSKQKGGLSSAVGSQTGVSPLTSPRNQRKASREARQV 529

  Fly   500 PPAPNQQR-------DYEQLFKSFER-------KQQQLDRM------------------------ 526
            ||...:::       |.|:....:.|       ::|:::|:                        
Zfish   530 PPRTRERKNSISEVSDKEEDLLEYHRWQREERMREQEMERLERQRLETILNLCAEYNKSDPPVGV 594

  Fly   527 -------------------------VPAKRSNK----NINNLTLNLQSVESQTQSPKPSRKPAPA 562
                                     ||.:.|::    ..:||.....|.|||.|..:.:......
Zfish   595 DAGRVCLFPGMEEVSVRRPGPDPVSVPGQSSHRQRESEEDNLKEECSSTESQHQEHEDTSVLGQQ 659

  Fly   563 PRSIHLEQRQRR------ELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQAL 621
            .| ::||:.:.|      ||..|...|::::.|....|.:|...|: ||: .|.......:|:.:
Zfish   660 ER-VYLEEERLRILARVDELKTRVTDLEQQIQESRQEAEMERALLQ-GER-RAELDQVEAELEII 721

  Fly   622 QNRVCRLEAQRNATRVMEENQQAKLKQSIEI---KQDQLKKLRAMLKQKPNN--ACLKEELQLVC 681
            .....:|....|||:..:|.::||:....::   .:|...:|:..|.:.|.:  ..|:|:|....
Zfish   722 NQLQLKLNEVENATQREKEKERAKVSAERDVLARLKDSYSELKGQLHKCPESLREHLQEQLTRKV 786

  Fly   682 ESLESDRKTFEDLEFQYFEEES------------------EHHASHEEFKRQEQRLMLEAELAAL 728
            |:|||..|.||||||:..|.||                  |:|  ....||:|:...||.:...|
Zfish   787 EALESATKRFEDLEFRQLERESGIEEEKETVGRQLLQEKAEYH--RNVAKRKEKMAALEIQANQL 849

  Fly   729 RIQIGPD-----------------EEEPGSP--------------TSPGSTGSNLV--------- 753
            .:|...|                 |:|..|.              :.|.||...::         
Zfish   850 GLQAAQDCERMAKDRTLALQMLHKEKERLSSLEKRYQSLTGGKNFSKPTSTKEEVLYISEPDFLD 914

  Fly   754 -----NGVM-SQSLFGSAELLCPKRRNQEDLMSKSVNENMFYNHKIEANTSTPKR--LPLQLFED 810
                 |.:: |.|...|...:| ..|.||:.:..|....|:.|..:.|.|::|..  |||.:..|
Zfish   915 ELPTQNSLLPSSSTQRSTPQIC-SNRPQEEYLKLSDVYKMYGNGCVPAQTASPNSLCLPLAVTSD 978

  Fly   811 LAGGSCEQISFNLSLQGDRFEVNPLERRVPSQDDIDRSCKVANDA--PISASQ----GASTKIF- 868
            ........:|....|.|           :|..|....|...:..|  |..:|.    |:|..:. 
Zfish   979 TPREEYVTVSQLNQLFG-----------MPKVDPYPTSSVQSFQAIDPAHSSHTSQCGSSQSLLV 1032

  Fly   869 --------DSIMEIERNR---------------------KLLLAQQGHQVIEHERQKMYDLK--- 901
                    .||..::..|                     |.|.:::..|:.:.:.:....|.   
Zfish  1033 ETQPAWSRPSIPRLDSERWYQEIMAAGQPSHSCPPPLPAKCLSSRKPMQMCKQDGETNGTLSGRN 1097

  Fly   902 --KKSHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLF--EKTELQKLNQK--------PGEP 954
              .||..:....||     .::.:|||:..:.|     |:  :.:.::.::.|        .|.|
Zfish  1098 TPTKSLPDLSPAYL-----DIDSKRQLDLQSRG-----LYTCDDSRIRPMDHKLSHWGAPPSGAP 1152

  Fly   955 V--DDQVQKIAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGG 1017
            :  ...:...|.....:..:..|..||.:..|:.:||..:.      ..||             .
Zfish  1153 MVHHSILHHQAPPAGESTYDTLSLESSDSVETSVSTGNNSA------CSPE-------------S 1198

  Fly  1018 SGGAGGANQMVARSPRPLSEANNCDATIEAPKFANGMDSSASPAVADNKRASSNSQ----DTASA 1078
            |.|..|..  :....:.|.||....|.:...: ...:.:......|:.:|.....:    :||  
Zfish  1199 SNGLAGLR--LEEMEKMLKEAQQEKARLVESR-EREVQARKQMLEAERRRREEVERRLLDETA-- 1258

  Fly  1079 GSGSGNSGSGGSTASDRKRVLPK----------HQRPLTRYLPIFSPDLNLRHHIETAGHQIDPC 1133
                           .|:|::.:          ..||:||||||...:.:||.|:|::||.:|.|
Zfish  1259 ---------------HRQRLVEEEVKMREKQCSQARPMTRYLPIRKEEFDLRSHVESSGHSVDTC 1308

  Fly  1134 PHVFVDAHSCRGYLHKLGATFHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDH 1198
            .:|.|....|:|:|.|:|....:|.:||||.||.:....||.||.|.|.:|..||..|:|||.||
Zfish  1309 AYVIVTEKMCKGHLVKMGGKIKSWKKRWFVFDRLKRTFSYYVDKHETKLKGVIYFQAIEEVYYDH 1373

  Fly  1199 L-NASKSGRPHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243
            | :|:||..|..||.|||..|.|.:.|.|..|.|||:|.|:|||:|
Zfish  1374 LRSATKSPNPSLTFCVKTHDRLYFMVAPSPEAMRIWMDVIVTGAEG 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5004NP_573195.1 FHA 41..104 CDD:278899 20/62 (32%)
PH-like 1142..1242 CDD:302622 49/100 (49%)
PH 1143..1237 CDD:278594 46/94 (49%)
phldb1aXP_694648.5 FHA 54..149 CDD:238017 39/97 (40%)
Lebercilin 672..845 CDD:292252 47/176 (27%)
SPEC 697..888 CDD:295325 47/194 (24%)
PH_PHLDB1_2 1314..1418 CDD:270192 49/103 (48%)
PH 1317..1413 CDD:278594 46/95 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 210 1.000 Domainoid score I2757
eggNOG 1 0.900 - - E1_2C17U
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 306 1.000 Inparanoid score I2617
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D45023at33208
OrthoFinder 1 1.000 - - FOG0003925
OrthoInspector 1 1.000 - - otm24478
orthoMCL 1 0.900 - - OOG6_105283
Panther 1 1.100 - - O PTHR12156
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6281
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1110.920

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