DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and Klp54D

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	761	Identity:	140/761 - (18%)
Similarity:	257/761 - (33%)	Gaps:	221/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTIYRSDANEVTLVPEKDSRLLIDG 87
            |||..|:..|.:::...:..||||.:..|..:            :|..:|....||.:..:::..
  Fly   121 GGGGGSSRNTPYFLRSRENEIGSADTLEIVAS------------KSTGSEECSTPEDNINVVVRV 173

  Fly    88 APILEETKLSQ-GAMITI-GNSNYLRFNNPDEAQMMRSAMGSNERISMPQIDFTQSARQAHELSQ 150
            .|:.::.|..: |:.:.. ||...:...|  :....||....:.|:....:.|...|.|...|..
  Fly   174 RPLNDKEKRDRHGSTLQFPGNGQVILEGN--DVGQKRSHNRDSVRVFTYNVVFEPGATQEDILDY 236

  Fly   151 S-------LELESFYESII--NPINNPSTYELECPKVFSSDLVTVNMPAKDVL-GQKYASFARNL 205
            |       :.:|.|..:..  ....:..|:.|..|    .||.......||.. |..:.||. .|
  Fly   237 SGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGP----PDLFVGKPNPKDPRHGLIFRSFL-YL 296

  Fly   206 AENHRNEKQLNNQYAKGVGSNGGYWNVPSNAAIYKEQHQQQHQQAPQDLLTKVNNDRYDRYP--- 267
            .:..:|.|.:|                    .:.|....:.:.:...|||    |....|.|
  Fly   297 FQLIKNRKDVN--------------------YVLKASFMEIYNERVIDLL----NPGSARKPLAV 337

  Fly   268 ----KAGGLQIYSMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSST 328
                |:||..:.::..|:.:                 ||:|:|.:..| ..||.::.| |.::..
  Fly   338 RWSKKSGGFFVENLFTVDCE-----------------ELDDLLAVLEE-GMRNRAVGS-HAMNDH 383

  Fly   329 SS----ITSSPIVQNRIKTNGSLPRDKN-KSPFPQQAG---------------VASSANISLL-- 371
            ||    |.:..|:.:: :|:|.:...|: |..|...||               .|::.|.||:
  Fly   384 SSRSHTILTVHILSDQ-QTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVL 447

  Fly   372 --SSSSGYENVRLLGPNRVEINGQIHVP-------ASAGDGGSSSGVSSNALAPTAAVRASHENL 427
              ..||..::.:..|          |:|       ....|..:.:||:    ...|.|..:|
  Fly   448 GYCISSLSDSKKRTG----------HIPYRDSQLTKLLADSLAGNGVT----LMIACVSPAH--- 495

  Fly   428 NQNHSATTGG-KYVPQSPRTKIRTN-----------CMSPKKDVSFGNAFALAISPPPLASSA-- 478
             .||:.|... :|..::.|  |||.           .:|.|:|:     .||.:....|.::.
  Fly   496 -YNHAETLNTLRYASRAKR--IRTKPVIKMDPREALILSLKRDI-----HALQMENDHLKAALNL 552

  Fly   479 --------------------VVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQL 523
                                .||:...:|:|   |..|...|.....  :..:|.|.:..:.:.|
  Fly   553 HHQAAPNGGPVENLLELQLDRVSSGGGVPVP---KVDLQRLPELDGS--ELAELVKLYMVENESL 612

  Fly   524 DRMVPAKRSNKNINNLTLNLQSVESQTQSPKPSRKPAPAPRSIHLEQRQRRELIQRRKQLKRELA 588
                      :..||....::....:.|               .:..|:...|:::.:.:.:...
  Fly   613 ----------RQENNHLFTVRETILRDQ---------------EIVCRENERLLKKLEDVNKVCV 652

  Fly   589 ELP---------PSAGIE--GLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVMEENQ 642
            ..|         |:.|.|  |.|:....:||.....|.|.::...:.    .|.|......:...
  Fly   653 RSPLIPARPAISPTTGKETPGTEIWTNPEPLQSPPGPDLPIEQRMSE----NANRRTDTAQKRID 713

  Fly   643 QAKLKQSIEIKQDQLKK----LRAMLKQKPNNACLKEELQLVCESL 684
            |.::.::|.|..:..:|    :...|...|..|..|:..:.:.:.|
  Fly   714 QKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAKQSTEFMPDML 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899	12/63 (19%)
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	84/424 (20%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	80/414 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930