DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and Klp98A

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	851	Identity:	156/851 - (18%)
Similarity:	298/851 - (35%)	Gaps:	245/851 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSA---ASCSISLNGSGVRPLH 62
            :.|.|....:.:.:..|||:.:... ::|.||::.:..|:|.|||.   .:..|.|.|.|:|..|
  Fly   441 LGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQH 504

  Fly    63 CTIYRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAMGS 127
            |:|:.. ...|||.|...::..::...|.|..::|||.:|.:|.:|..|||||.||..:|..: |
  Fly   505 CSIFLK-GGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDL-S 567

  Fly   128 NERISMPQIDFTQSARQAHELSQSLELESFY--ESIINPINNPS-TYELECPKVFSSDLVTVNMP 189
            ..::.|.::....|::      ::|...|.|  |...:|...|. .|..:.|       ::.:.|
  Fly   568 RSQLDMSRLSLITSSK------ENLLTCSIYSDEDGASPYKRPERQYYPQRP-------MSRDDP 619

  Fly   190 AKDVLGQKYASFARNLAENHRNEK-QLNNQYAKGVGSNGGYWNVPSNAAIYKEQHQ--------- 244
            ......:|......|..:....|: |:::||...|       ...:...|..||.:
  Fly   620 ELQDENRKILDTIENALKQLNVERVQMHDQYKTKV-------RKLTEELIRLEQEEMDGLQLLNC 677

  Fly   245 -QQHQQAPQD-LLTKVNNDRYD-----RYPKAGGLQIYSMNG-----VNSDINNGPATGNNSGTG 297
             :|...|.:| ||.:.||::..     |...|...|:.|...     |..::......|.....|
  Fly   678 REQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMG 742

  Fly   298 ----GGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSPIVQNRIKTNGSLPRDKNKSPFPQ 358
                .|..|.|.|.:               .||.:..:.::..:::.::.|....|..::....:
  Fly   743 MKIEEGTPLNDELLL---------------QVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEK 792

  Fly   359 Q----AGVASSANI--SLLSSSSGYENVRLLGPNRVEINGQIHVPASAGDGGSSSGVSSNALAPT 417
            :    |.....|.:  ::|...:..|.:||   .|.|                       :.|.:
  Fly   793 ERILNASTTKIAKVDETMLEIQAQLERLRL---ERAE-----------------------SEAES 831

  Fly   418 AAVRASHENL-----NQNHSATTGGKYVPQSPRTKIRTNCMSPKKDVSFGNAFALAISPPPLASS 477
            .|:||..:|:     |::.|.:|.........::.....|          :.|..|.|...|.||
  Fly   832 QAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETC----------DTFHTAQSNLSLVSS 886

  Fly   478 AVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQLDRMVPAKRSNKNINNLTLN 542
            ..::..:..|:.:.
  Fly   887 PTITEGQQSPLSNC--------------------------------------------------- 900

  Fly   543 LQSVESQTQSPKPSRKPAPAPRSIHLEQRQRRELIQRRKQLKRELAELPPSAGIEGLELKLGEQP 607
              |.:::.::                |..::.:|....::..| .....||:|.....:.:|...
  Fly   901 --SCDAEDEA----------------EDTRKDDLSGSSEETSR-TCTAGPSSGSGSGSVGIGGSG 946

  Fly   608 LAPSASPRLQLQALQNRVCRLEAQRNATRVMEENQQAKLKQSIEIKQDQLKKLRA---------- 662
            .|||.:|..|.....:.|| |:::..|  :::.......||::....:......:
  Fly   947 SAPSCTPSSQAIMSDSGVC-LDSRNQA--ILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVA 1008

  Fly   663 -------MLKQKPNNACLKEELQLVCESLESDRK---------TFEDLEFQYFEEESEHHASHEE 711
                   .|::|     :..:..|:.::||:|..         ..:||:.:|.:.|.|...|.::
  Fly  1009 RPYCPLHSLRRK-----IAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQD 1068

  Fly   712 FKRQ-----EQRLMLEA--ELAA--LRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAEL 767
            .:..     ::|..:|.  |||:  :|..:       .||||...:.|.:.:..|::|
  Fly  1069 LEAHAQCCADERSGMERQYELASSIMRSSV-------MSPTSMEESTSQIYSPSMTRS------- 1119

  Fly   768 LCPKRR 773
             ||..|
  Fly  1120 -CPSMR 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899	22/65 (34%)
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816
		KISc	3..371	CDD:214526
		Kinesin_assoc	370..478	CDD:292801	8/37 (22%)
		FHA	456..555	CDD:238017	33/100 (33%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930