DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and unc-104

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster

Alignment Length:	1463	Identity:	275/1463 - (18%)
Similarity:	478/1463 - (32%)	Gaps:	444/1463 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLTKKDPSLRVAA----SDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAAS---CSISLNGSGV 58
            |.:..|:..:.|..    ..||||:|......:...::||..|.|.:|:..:   ..|.|:||.:
  Fly   455 MGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHI 519

  Fly    59 RPLHCTIYRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMR- 122
            ...||| :.:..:.|||:|.||:.:.::|..::|...|..|:.:.:|.::..||.||::|:.:|
  Fly   520 LKEHCT-FENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRD 583

  Fly   123 ------SAMGSNERISMPQIDFTQSARQAHELSQSLELESFYESIINPINNPSTYE-LECPKVFS 180
                  .|....|:....|:|:..:..:..| .|.::|::..:..::.:......| |:..:.|.
  Fly   584 KIETENEAENEVEKTDTQQVDWNFAQCELLE-KQGIDLKAEMKKRLDNLEEQYKREKLQADQQFE 647

  Fly   181 SDLVT----VNMPAKDVLGQK-----YASFARNLAENHRNEKQLNN------------------- 217
            ....|    ::...|.|..|.     |:|::..  :.|:.|....|
  Fly   648 EQRKTYEARIDALQKQVEEQSMTMSMYSSYSPE--DFHQEEDVYTNPMYESCWTAREAGLAAWAF 710

  Fly   218 ---QYAKGVGSNGGYWNVPSNAAIYKEQH----------QQQ--------HQQAPQDLLTKV--- 258
               :|.:........|   .||...||.:          |.|        :...|.:|.:.|
  Fly   711 RKWRYHQFTSLRDDLW---GNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPV 772

  Fly   259 -NNDRYDRYPKAGGLQIYSMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNSMPST 322
             ..|.:...|.:..|....:    :|..|| ||.:.|.......||.|.:|      .|...|.:
  Fly   773 HQEDEFGAPPVSKTLVAVEV----TDTKNG-ATHHWSLEKLRYRLELMRQI------YNVESPPS 826

  Fly   323 HNVSSTSSITS-----SPIVQNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRL 382
            ..:..||.:.:     ||..|:..:....||.:   .|...:.|..:.||  |:.|....|.:|.
  Fly   827 SMLFDTSGMEALSGWISPPSQHPGQQAQLLPLE---PPVESERGRLTLAN--LIPSRQRLELMRE 886

  Fly   383 LGPNRVEINGQIHVPAS---------AGDG-----------GSSSGVSSNALAPTAAVR------ 421
            :..|..|::     |.|         .||.           |.|....||.|.|...|.
  Fly   887 MYHNEAEMS-----PTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVN 946

  Fly   422 ----------------ASHENLNQNHSATTGGKYVPQSPRTKIRTNCMSPKKDVS--FGNAFALA 468
                            ...|:::.|:......:.|......|.:...::.|.||.  ..|...
  Fly   947 ERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGL-- 1009

  Fly   469 ISPPPLASSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQ------------------RDYEQLFKS 515
              ...|.....|.:.:.|...|..:.....:.|..:.|                  .:|..:|..
  Fly  1010 --DSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIFCQ 1072

  Fly   516 FE--RKQQQLDRMVPAKRSNK-------NINNLTLNLQS--VESQTQSP-----------KPSRK 558
            |.  .:.::.....|.|.|..       ::.|:|:.:..  :|.....|           .|..|
  Fly  1073 FNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHK 1137

  Fly   559 PA-------PAPRSIHLEQRQRRELIQRRKQLKRELAELPPSAGIEG--LELKLGEQPLAPSASP 614
            .|       |.||.:                       ||||..|..  ...|.|..|.||:::.
  Fly  1138 DAKQDFVSRPPPRRM-----------------------LPPSIPISQPVRSPKFGPLPCAPTSTV 1179

  Fly   615 RLQLQAL-QNRVCRLEAQ-RNATRVMEENQQAKLKQSIEIKQDQLKKLRAMLKQKPNNACLKEEL 677
            ..:...| ...:|.|... .....|:|.:.....:....:.|...:::|..:..:|......:::
  Fly  1180 LAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDI 1244

  Fly   678 -QLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRLMLEAELAALRIQIGPDE--EEP 739
             :||...:   |.|.|..:.|                        :.:...|.:.:.|.|  |.|
  Fly  1245 NELVVGRI---RNTPESSDEQ------------------------DEDACVLSLGLFPGEALEVP 1282

  Fly   740 GSPTS----PGSTGSNLVNGVMSQSLFGSAELL------------CPKRRNQEDLMSKSVNENMF 788
            |...|    ..:..|:|.|..:...:....|.:            |.:    ..:::|.:: .:.
  Fly  1283 GDDRSFYRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCAR----PAIITKDLS-MVI 1342

  Fly   789 YNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDRFEVNPLERRVPSQDDIDRSCKVAN 853
            |..  :|.|. |:.|     :.|..|...               ||...|:....::  :.:.|:
  Fly  1343 YGR--DARTG-PRSL-----KHLFSGQYR---------------NPEANRLTGVYEL--ALRRAS 1382

  Fly   854 DAPISASQGASTKIFDSIMEIERNRKLL--LAQQGHQVI-EHERQKMYDLKK--KSHDEARTQYL 913
            :|.....|....::.|:.....|..:.|  ...:|..:| :|:    ::|:|  :..:..|.::|
  Fly  1383 EAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQ----WELEKLTRLEEVGRMRHL 1443

  Fly   914 LSTQQSMEQQRQLESDANGGKDAKLFEKTELQKLN---------------QKPGEPVDDQVQKIA 963
            |..::      :|..|.|.....    |||....|               |.|..||.|. |:|.
  Fly  1444 LLLRE------RLGMDTNPNPTT----KTEKDVCNLAARAATSPVHMVIPQSPQTPVKDP-QQII 1497

  Fly   964 GDKENNVQNR-------KSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGA 1021
            .::|.|.:.:       |..                   |.|:::.|
  Fly  1498 PEREYNQREQDLMLKCLKLV-------------------QGRYTKSE------------------ 1525

  Fly  1022 GGANQMVARSPRPLSEANNCDATIEAPKFANGMDSSASPAVADNK---RASSNSQDTASAGSGSG 1083
              ||....:|....|:....|.|:..         .:|.::.:||   |....|.|.|.|.:|
  Fly  1526 --ANDTQTQSDVSPSDEGCADMTVSC---------ISSNSMENNKFVIRRRLCSPDRADAPNG-- 1577

  Fly  1084 NSGSGGSTASDRKRVLPKHQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLH 1148
                              .:.|    .|...|.|.||.::... .:|...|.|     :.:|.|:
  Fly  1578 ------------------WEAP----APATQPALPLRLYVPEL-EEIRVSPVV-----ARKGLLN 1614

  Fly  1149 KLGATFHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLD----HLNASKSGR--- 1206
            .|......|.:|| |:.|:....||   :||:.|        ::...|:    |:..|:...
  Fly  1615 VLEHGGSGWKKRW-VIVRRPYVFIY---RSEKDP--------VERAVLNLATAHVECSEDQAAMV 1667

  Fly  1207 --PHCTFIVKTKKRSYNLQAASDSAARIWIDAI 1237
              |: ||.|.||.|.|.||...|.....|:.||
  Fly  1668 KIPN-TFSVVTKHRGYLLQTLGDKEVHDWLYAI 1699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899	19/65 (29%)
		PH-like	1142..1242	CDD:302622	30/105 (29%)
		PH	1143..1237	CDD:278594	28/102 (27%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816
		KISc	3..358	CDD:214526
		Kinesin_assoc	355..498	CDD:292801	10/42 (24%)
		FHA	475..574	CDD:238017	30/99 (30%)
		KIF1B	878..923	CDD:289208	8/49 (16%)
		DUF3694	1246..1347	CDD:289256	20/134 (15%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	32/116 (28%)
		PH	1607..1700	CDD:278594	31/111 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930