DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and Khc-73

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster

Alignment Length:	1608	Identity:	300/1608 - (18%)
Similarity:	516/1608 - (32%)	Gaps:	542/1608 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIH----IGDTTIGSAASCSISLNGSGVRPL 61
            |.::.:...::|..:..:||:|........:.::|:.    ||..|| |.....|.|:|.|::|.
  Fly   431 MGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTI-SGQQPDIQLSGLGIQPE 494

  Fly    62 HCTIYRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDE--------- 117
            ||.|...|:. :.:.|.:.:|..::|:..:|:|.|..|..|..||.::.|.|:|..
  Fly   495 HCVITIEDSG-LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASE 558

  Fly   118 ----AQMM-----RSAMGSNERISMP-QIDFTQSARQAHELSQSLELE---SFYESIINPINN-- 167
                ||::     |..:..||..:.| |....:..|| ||..:.:.||   ..||.....:.|
  Fly   559 PQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQ-HEEDKQVALEKQRQEYERQFQQLRNIL 622

  Fly   168 -PST-YELECP-KVFSSDLVTVNMPAKDVLGQKYAS-----FARNLAENHRNEKQLN------NQ 218
             ||| |....| .......:|.|.|...:..:|:|.     |.|:|.:...:..:.|      |.
  Fly   623 SPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANF 687

  Fly   219 YAKGVGSNGGY---WNVPSNAAIYKEQHQQQHQQAPQDLLTKVNNDRYDRYPKAGGLQIYSMNGV 280
            .|:.:.....:   ..:|. |.:...:.:......|..|:.:.|:          |.||::|..:
  Fly   688 LAEEMEKKTKFSVTLQIPP-ANLSPNRRRGAFVSEPAILVKRTNS----------GSQIWTMEKL 741

  Fly   281 NSDINNGPATGNNSGTGGGAELEDMLKICTEYADR-------NNSMP--------STHNVSSTSS 330
            .:                  :|.||.::..|:.:|       :|:.|        ..||:...::
  Fly   742 EN------------------KLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVAN 788

  Fly   331 I------------TSSPI------VQNRIKTN-----GSLPRDKNKSPFPQQAG----------- 361
            |            ..:||      |..|::..     |.:|:|:......:.:|
  Fly   789 IFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVD 853

  Fly   362 -----------VASSANISLLSSSSGYENVRLLGPNRVEINGQIHVPASAGD------------- 402
                       :..::.:.|..|:..:......|...:.: ..|:..::|.|
  Fly   854 PTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVV-PVINAESTAHDQNMVFKFEHTQDF 917

  Fly   403 ----------------------GGSSSGVS---------SNALAPTAAVRAS------------H 424
                                  |..|:|.|         ..|.|.:...|.:            |
  Fly   918 TVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIH 982

  Fly   425 ENLNQN-----------HSATTGGKY---VPQSPRTKIRTNCMSPKKDVSFGNAFALAISPPPLA 475
            | ||.|           :...|||.|   ..|..|..:|.      |.|.  |:..|     |:.
  Fly   983 E-LNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRV------KPVQ--NSGTL-----PII 1033

  Fly   476 SSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDY----EQLFKSFERKQQQLDRMVP--AKRSNK 534
            ..::|:    :.|.|:.......:|....|:.|.    |:..::..|::|.||:.:.  .|:..|
  Fly  1034 CQSIVN----VAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEK 1094

  Fly   535 NINNLTLNLQSVE---SQTQSPKPSRKPAP------APRSIHLEQRQRRELIQRRKQLKRELAEL 590
            |.......|..|.   |.|:.......|||      ||.|..
  Fly  1095 NEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWE----------------------- 1136

  Fly   591 PPSAGIEG----LELKL-GEQPLAPSASPRLQ---------------------LQALQNRVC--- 626
            ||| |:|.    |.|.| |:...|.:.:..|.                     ||.|...||
  Fly  1137 PPS-GMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVA 1200

  Fly   627 ----RLEAQRNATRVMEENQQAKL--------------------KQSIEIKQ-----DQLKKLRA 662
                .:...:...||.|.|::..|                    :.||.||:     |:|||.|.
  Fly  1201 SWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRL 1265

  Fly   663 MLKQKPNNACLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRLMLE----- 722
            :   :..||..:.  .:..|.:.:..|..|:||.:  |..::..||.::....:....:|
  Fly  1266 V---RGENAIWQS--GVTYEVVSNIPKASEELEDR--ESLAQLAASGDDCSASDGETYIEKYTRG 1323

  Fly   723 -------AELAALRIQIGPDEEEP--GSPTSPGSTGSNLVNGVMSQSLFGSAELLCPKRRNQEDL 778
                   ..|..||..:...|.|.  |.|.|...|.| :.|  .||.:...|.:        |.|
  Fly  1324 VSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVS-VPN--FSQIMRFDASM--------ESL 1377

  Fly   779 MSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDRFEVNPLERRVPSQD 843
            ::...:|:                     |.||          |.|..|::|  .|.........
  Fly  1378 LNVGRSES---------------------FADL----------NNSALGNKF--TPAGHSPAGAG 1409

  Fly   844 DIDRSCK------VANDAPISA---SQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHERQKM-- 897
            .:.||..      .::|:|..|   :..|::|:....|.......|    .||:.::.|.:..
  Fly  1410 GVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPL----GGHRSLDEEPEDSYS 1470

  Fly   898 -------YDLKKKSHDEARTQYLLSTQQSMEQQRQLESDAN-------GGKDAKLFEKTELQKLN 948
                   |:.:::.:....|:..|:..::|:....:.|.:|       ...:|.:...|.|..|:
  Fly  1471 DSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLS 1535

  Fly   949 QKPGEPVDDQVQKIAGDKENNVQN------------------RKSTGSSPTTTTTTTTGGGTTPQ 995
            ...........|.::.   ||:.|                  |.::.|.|.............|:
  Fly  1536 MSSSTSSGYGSQAVSC---NNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPK 1597

  Fly   996 QQRHSQPELE---------HHAIALGIGGGGSGGAGGANQM---------VARSPRPLSEANNCD 1042
            .:...|||.:         |....|..............|:         :...|:|||...:.:
  Fly  1598 AKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLE 1662

  Fly  1043 ATIEAPK----FA----NGMDSSAS-------------------PAVADNKRASSNSQDTASAGS 1080
            .::..||    ||    ||..||..                   ||....:|..||:|..::  .
  Fly  1663 ESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSN--G 1725

  Fly  1081 GSGNSGSGGSTASDR--KRVLPKHQRPLTRYLPIFSPDLNLRHHIETAGHQIDP--------CPH 1135
            .|.|:.:.|:|.:.|  .|........|..||.         ..|.|:..::|.        .|.
  Fly  1726 NSINNNNNGTTQAPRINHRASVAKMEGLAAYLD---------SSIMTSSTEVDEESKDVELVLPE 1781

  Fly  1136 -------VFVDAHSCRGYLHKLGAT-FHAWSRRWFVL---------DRQRSALIYYSDKSERKPR 1183
                   |.:..::..|.:..:|.| |...:  |..:         |.....:.|:    :.||:
  Fly  1782 WIVVGESVLIRPYNTSGVIRFVGTTEFQPGA--WIGVELDTPTGKNDGSVKGVQYF----QCKPK 1840

  Fly  1184 GGAYFATIDEVYLDHLNASKSGRPHCTFIVKTKKRSYNLQAASDSAAR 1231
            .| .|...|::.||     |.|:         ..|:|.....|:|.::
  Fly  1841 HG-MFVRSDKLMLD-----KRGK---------AMRAYKAAEKSNSISK 1873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899	20/62 (32%)
		PH-like	1142..1242	CDD:302622	20/100 (20%)
		PH	1143..1237	CDD:278594	20/99 (20%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816
		KISc	6..359	CDD:214526
		Kinesin_assoc	356..468	CDD:292801	6/36 (17%)
		FHA	446..546	CDD:238017	29/101 (29%)
		KIF1B	741..786	CDD:289208	9/62 (15%)
		DUF3694	<1196..1252	CDD:289256	10/55 (18%)
		CAP_GLY	1786..1850	CDD:279625	13/70 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930