DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and cos

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	1286	Identity:	233/1286 - (18%)
Similarity:	419/1286 - (32%)	Gaps:	398/1286 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PEKDSRLLIDGA----------------PILEETKLSQGA-------MITI--------GNSNYL 110
            |:||::.:.:||                |.:.||..:..|       ..||        |..:|
  Fly    29 PKKDAQAVDEGADSKDSEAQVPAAEKDNPSISETDPNGNAEQDSAADSKTIPDANGNDSGQKDY- 92

  Fly   111 RFNNPDEAQMMRSAMGSNERISMP-----------------QIDFTQSARQAHELSQSLELESFY 158
                ||.|..:::...|...:.:|                 |:. ..:....|.|..|...|..|
  Fly    93 ----PDSAYCVQAIPISASALGLPSALPGGDPMDSIAAGLIQVG-PHTVPVTHALPSSSSQEQVY 152

  Fly   159 ESIINPINNPSTYELECPKVFSSDLVTVNMPAKDVLGQKYASFAR----NLAENHRNEKQL---- 215
            ...:.|:   .|..||   .|.:.:||.....:   |:.|..:..    .|.::.....||
  Fly   153 HQTVFPL---ITLFLE---GFDASVVTYGQRGQ---GKSYTLYGNVQDPTLTDSTEGVVQLCVRD 208

  Fly   216 ---------NNQYAKGVG---SNGG--------------------YW---------NVPSNAAIY 239
                     ...||..||   ..||                    :|         ::|::....
  Fly   209 IFSHISLHPERTYAINVGFVEICGGDVCDLLGMGNIHCTNVDAVFHWLQVGLSARQSLPAHTLFT 273

  Fly   240 KEQHQQ--------QHQQAP---QDLL-TKVNNDRYDRYPKAGGL----QIYS-------MNGVN 281
            ....||        ||:.:.   .||. |:...|:....|...||    |:.|       |.|||
  Fly   274 LTLEQQWVSKEGLLQHRLSTASFSDLCGTERCGDQPPGRPLDAGLCMLEQVISTLTDPGLMYGVN 338

  Fly   282 SDINNGPATGN---NSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSPIVQNRIKT 343
            .:|..|..|..   ....||.|  :.::.:|.                       ||:.::..:|
  Fly   339 GNIPYGQTTLTTLLKDSFGGRA--QTLVILCV-----------------------SPLEEHLPET 378

  Fly   344 NGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVEINGQIHVPASAGDGG--SS 406
            .|:|     :..|..|.    ..|..::::.|. :|..::.|..       .||.|....|  |.
  Fly   379 LGNL-----QFAFKVQC----VRNFVIMNTYSD-DNTMIVQPAE-------PVPESNSSAGPLSQ 426

  Fly   407 SGVSSNALAPTAAVRASH--ENLNQNHSATTGGKYVPQSPRTKIR---------TNCMSPKKDVS 460
            :|...|.....||.:.|.  .|.....|.....|.:.:..:.:|.         ..|:|
  Fly   427 AGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLS------ 485

  Fly   461 FGNAFALAISPPPLASSAVVSTSKPIPIPSMVKP----PLAPKPPAPNQQRD------------- 508
                          ::.|:....:.:||....:|    ..|....:||...:
  Fly   486 --------------STEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPDLD 536

  Fly   509 --YEQLFKSFERKQQQLDRMVPAKRSNKNINNLTLNLQSVESQTQSPKPSRKPAPAPRSIHLEQR 571
              .|.|.:.|..|   .|.::..|.:.....:....:||.:.:.::..|.........||    .
  Fly   537 DKIESLMEEFRDK---TDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSI----G 594

  Fly   572 QRRELIQRRKQLK-RELAEL------------PPSAGIEGLELKLGE---QPLAPSASPRLQLQA 620
            .||..:|....|. .|||.|            .|.:.::.||...||   |....:|:....::.
  Fly   595 SRRRSVQPGASLSTAELAMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQ 659

  Fly   621 LQNRVCRLEAQRNATRVMEENQQAKLKQSIEIKQDQLKKL------RAMLKQKPNNACLKEELQL 679
            ||.::.:|.|:...    ::.|..:::::|::||:.:.:|      |:..||:.:..  :.:|:.
  Fly   660 LQKKLRKLVAEIEG----KQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKK--RAKLEA 718

  Fly   680 VCESL---------------ESDRKT---------FEDL---------------EFQYFEEESEH 705
            .|:..               |.:|.|         .|||               :.|....||..
  Fly   719 ECDKAKKQLGKALVQGRDQSEIERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRK 783

  Fly   706 HASHEEFKRQEQ---RLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAEL 767
            .|...:.|.:::   |..:|||||.||......:|...:..||...|..|  ..:...:.....:
  Fly   784 QADDLQKKLRKECKLRCQMEAELAKLRESRETGKELVKAQGSPEQQGRQL--KAVQARITHLNHI 846

  Fly   768 LCPKRRNQEDLMSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDRFEV 832
            |..|..|.|:.......|.:  .|:|. |....:.|.|:          |:...:..|:.|:...
  Fly   847 LREKSDNLEEQPGPEQQETL--RHEIR-NLRGTRDLLLE----------ERCHLDRKLKRDKVLT 898

  Fly   833 NPLERRVPSQDD----IDRSCKVANDAPISASQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHE 893
            ...||::...|:    ||.:.:..|:. |:..:...|.  |.|.. |:..::|:|:......|..
  Fly   899 QKEERKLLECDEAIEAIDAAIEFKNEM-ITGHRSIDTS--DRIQR-EKGEQMLMARLNRLSTEEM 959

  Fly   894 RQKMY-------DLKKKSHD-EARTQYLLSTQQSMEQQRQLESDA------NGGKDAKLFEKTEL 944
            |..:|       ||:..|.. |.:...|...:.:.|.:.::.|:|      .|.::|.|.::...
  Fly   960 RTLLYKYFTKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQRQHE 1024

  Fly   945 QKLNQKPGEPVDDQVQKIAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAI 1009
            .||..        .::.:|         .:::.||.:............|..|..|..:.:|.
  Fly  1025 MKLTL--------MLRHMA---------EETSASSASYGERALAPACVAPPVQASSDFDYDHF-- 1070

  Fly  1010 ALGIGGGGSGGAGGANQMVARSPRPLSEANNCDATIE---------------APKFANGMDSSAS 1059
                    ..|.|..::.:.::|:|:...:..|...:               ..::|:...:.:|
  Fly  1071 --------YKGGGNPSKALIKAPKPMPTGSALDKYKDKEQRSGRNIFAKFHVLTRYASAAAAGSS 1127

  Fly  1060 PAVADNKRASSNSQDTASAGSGSGNSGSGGSTASDR----------KRVLP 1100
            .:.|:...|...|..||:|.:.|..:........|:          ||::|
  Fly  1128 GSTAEESTALIESTTTATATTTSTTTTGAVGKVKDKALVSFRPEQLKRLMP 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899	9/49 (18%)
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	55/296 (19%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	41/206 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930