DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and Klp31E

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster

Alignment Length:	1032	Identity:	195/1032 - (18%)
Similarity:	338/1032 - (32%)	Gaps:	353/1032 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 GPATGNNSGTGGGAEL-----------EDMLKICTEYADRNNSMPSTHNVSSTSSITSS---PIV 337
            |.:|..:...||..:.           ||:..:...: ::|::.....:.|...:|:.:   ||.
  Fly   137 GSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPF-NKNSNFKIHEDASGQITISGASIKPIY 200

  Fly   338 QNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENV---------RLLGP------NR 387
            |         |.|..|  :.||..:|.:...:.::..|...:.         |||.|      |.
  Fly   201 Q---------PHDALK--YLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDND 254

  Fly   388 VE-INGQIHVPASAGDGGSSSGVSSNALAPTAAV-RASHENLNQNHSATTGGKYVPQSPRTKIRT 450
            :| :..:.|....||         |..|..|.|. ..:.|.::.|......|
  Fly   255 LETLTSKFHFVDLAG---------SERLKRTQATGERAREGISINCGLLALG------------- 297

  Fly   451 NCMSPKKDVSFGNAFALAISPP-------PLASSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRD 508
            ||:|     :.|:....|:..|       .|...::...|:.:.| :.|.|          ..||
  Fly   298 NCIS-----ALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMI-ACVSP----------SDRD 346

  Fly   509 YEQLFKSFERKQQQLDRMVPAKRSNKNINNLTLNLQSVESQTQSPKPSRKPAPAPRSIHLEQRQR 573
            :          .:.|:.:..|.|: :||.|.....|...|:|.|
  Fly   347 F----------METLNTLKYANRA-RNIKNKVKINQDQSSRTIS--------------------- 379

  Fly   574 RELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVM 638
                    ||:||:|.|.    :|.||.|.|:                    ..::.:.|.|...
  Fly   380 --------QLRREIAALQ----LELLEYKQGK--------------------LIVDCEGNTTISD 412

  Fly   639 EENQQAKLKQSIEIKQDQLKKLR---AMLKQKPNNACLKEELQLVCESLESDRKTFEDLEF---- 696
            ..|:...|...|:..|.:||.|:   |.|.|:  ||.||..|.|  ....||..:  |:|.
  Fly   413 TFNENKLLLSEIKRLQQRLKSLQSTIATLTQR--NADLKTNLDL--NKWTSDDNS--DVEIAKVV 471

  Fly   697 -QYFEE---------ESEHHASHEEFKRQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSN 751
             ||..|         |||.|....|.|                           :.|||.:
  Fly   472 GQYMLEIEELQTKLIESEEHRKQMEIK---------------------------ATTSPRN---- 505

  Fly   752 LVNGVMSQSLFGSAELLCPKR---RNQEDLMSKSV----NENMFYNHKIEANTSTPKRLPLQLFE 809
                  ::.::.|..:...|:   |.:|.|||:|:    |:|:.......|::.:...   ::.:
  Fly   506 ------AKPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAE---EVVK 561

  Fly   810 DLAGGSCE-----QISFNLSLQGDRFEVNPLERRVPSQDDID-RSCKVAN------DAPISASQG 862
            ||.....:     ::...|.|...|:|    :.|...::.:. ..||:.|      |...:.:..
  Fly   562 DLEAIDNDIEMRTKLIEQLELTNSRYE----QMRTHYEEKLSVLYCKIENTQKERDDVLANMTTS 622

  Fly   863 ASTKIFDSIMEIERN------------RKLLLAQQGHQVIEHERQKMYDLKKKSHDEARTQYLLS 915
            .||...||:.:::.:            |||..||:     ||.|.|.   :.||| |.|    :.
  Fly   623 VSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQR-----EHIRSKQ---QLKSH-EVR----IG 674

  Fly   916 TQQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNVQNRKSTGSSP 980
            |         |.::.|..|.||:   ..::|::|:             .::....::|||...:.
  Fly   675 T---------LRNELNELKFAKV---KLMKKMSQQ-------------SNRHKQEESRKSKEIAQ 714

  Fly   981 TTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPLSEANNCDATI 1045
                       ...:|:|.....|...|           ......|::.|         ..:..|
  Fly   715 -----------LLKEQRRQKNAVLTLEA-----------KVSAKEQILKR---------KTEEVI 748

  Fly  1046 EAPKFANGMDSSASPAVADNKRASSNSQDTASAGSGSGNSGSGGSTASDRKRVLPKHQRPLTRYL 1110
            ...|...|.....:||...:|.|:.:...|.||.....|.......|:..::::.:.::.|.|.:
  Fly   749 ALRKSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLEKELERLI 813

  Fly  1111 ---PIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGATFHAWSRRWFVLDRQRSALI 1172
               ...|.:||:..:.:||..|.|....|                            |..::.:.
  Fly   814 LEREDLSRELNIMENGQTADRQTDEFNEV----------------------------DNLKTNIS 850

  Fly  1173 YYSDKSERKPRGGAYFATIDEVYLDHLNASKSGRPHCTFIVKTKKRSYNLQAASDSA 1229
            |..:..|...:....|....:....|:|..:|.....:.:.:.|   :.||..||:|
  Fly   851 YIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAK---FILQKFSDTA 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622	13/88 (15%)
		PH	1143..1237	CDD:278594	13/87 (15%)
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	52/287 (18%)
		KISc	13..370	CDD:214526	54/293 (18%)
		KASH_CCD	409..589	CDD:291334	50/229 (22%)
		RasGAP	<685..750	CDD:295371	14/111 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930