DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5004 and Phldb3

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	NP_001382020.1	Gene:	Phldb3 / 308431	RGDID:	1561121	Length:	636	Species:	Rattus norvegicus

Alignment Length:	813	Identity:	190/813 - (23%)
Similarity:	299/813 - (36%)	Gaps:	231/813 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 PPPLASSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDY-EQLFKSFERKQQQLDRMVPAKRSNK 534
            ||.:...||     .:....:|:|...|:.|..:::.:. .:|....|..:|:.:..|....|.
  Rat    13 PPQVPECAV-----EVQPQGVVQPQGHPENPQEHKEPEVPAELPSCQEAGRQEEEEEVEEGSST- 71

  Fly   535 NINNLTLNLQSVESQTQSPKPSRKPA-PAP--------------RSIHLEQRQRRELIQRR-KQL 583
                     :|...:.::...::.|| |:|              |...||...|..|:::| |:|
  Rat    72 ---------ESCREEPEATLAAQIPATPSPCLPGEELRGAARRLRGQQLEALTRVALMEQRVKEL 127

  Fly   584 KRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNA--TRVMEENQQAKL 646
            :|:..||.....:| :.|..||......|:.|.:.|..:....|:|:|:::  .|..|:.|.::.
  Rat   128 QRQKKELRIEMEVE-VALLRGELAGERVAARREEEQLRELLGQRVESQQSSQEQREQEQRQLSQE 191

  Fly   647 KQSIEIKQDQLKKLRAMLKQKPNN--ACLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASH 709
            :..:|..:.:|::.:..|..:|.:  ..|.:.:|.:.|.|::.::|:||||||..|.||
  Rat   192 RDHVENLRQRLREAQGHLDSQPEDQRERLSQGVQEIREQLDAAQRTYEDLEFQQLERES------ 250

  Fly   710 EEFKRQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAELLCPKRRN 774
                               |:     |||..||..|                       .|..:.
  Rat   251 -------------------RV-----EEERESPDVP-----------------------APDSKV 268

  Fly   775 QEDLMSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGSCEQISFNLSLQGDRFEVNPLERRV 839
            :|                ::|:.:..||..|.|.|.|.... ||::
  Rat   269 RE----------------LQASVAQHKRRILVLEEQLRSLG-EQMA------------------- 297

  Fly   840 PSQDDIDRSCKVANDAPISASQGASTKIFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLK--- 901
                              :.|.|.|.|                .::..|.:..||.::::|.
  Rat   298 ------------------AESWGLSRK----------------KEEAVQALTQERSRLFELNCLQ 328

  Fly   902 ------KKSHDEARTQYLLSTQQSMEQ----QRQLESDANGGKDAKLFEKTELQKLNQKPGEPVD 956
                  ....|:|.|: ||.||::..|    |..:...|.....:.||.              |.
  Rat   329 GTCGGDFSEPDQALTK-LLFTQKTDRQLLVLQDPIAHAAASSTSSCLFS--------------VH 378

  Fly   957 DQVQKIAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGA 1021
            ..:|...|        .:.|||.|.......:..|::.....|....||..|:...:|..|.
  Rat   379 SSLQGSIG--------LQRTGSLPRRRGDRASQRGSSRPLSVHCTGPLEASALTQAVGTPGR--- 432

  Fly  1022 GGANQMVARSPRPLSEANNCDA----TIEAPKFANGMDSSASPAVADNKRASSNSQDTASAGSGS 1082
                       .||.:..||..    .:..|..|: |:.....|||:.:|       ...|..|.
  Rat   433 -----------HPLYQLLNCGPGNRNPVLHPDIAH-MERLLKQAVAERER-------LLKAREGM 478

  Fly  1083 GNSGSGGSTASDRKRVLPKHQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYL 1147
            ..|....:..:....:.|.|        |....||:|..|:|..||..:.|||:.|....|||.|
  Rat   479 KRSQESSTDPAVPAIMAPPH--------PPGPQDLDLAQHLERWGHNPESCPHLRVSGGYCRGPL 535

  Fly  1148 HKLGATFHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHLN-ASKSGRPHCTF 1211
            .|:|.....|.:|||..|||...|.||:||.|.|.:|..||..|:|||.|||. ||||..|..||
  Rat   536 VKMGGRIKTWRKRWFCFDRQARRLAYYADKEESKLKGVIYFQAIEEVYCDHLRCASKSPNPLLTF 600

  Fly  1212 IVKTKKRSYNLQAASDSAARIWIDAIITGAQGN 1244
            .|||.:|.:.:.|.:..|.|||:..|.|.|..|
  Rat   601 CVKTYERLFYMVAPNPEAMRIWMVVIGTAADEN 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622	48/100 (48%)
		PH	1143..1237	CDD:278594	46/94 (49%)
Phldb3	NP_001382020.1	SMC_prok_B	110..>324	CDD:274008	66/337 (20%)
Phldb3	NP_001382020.1	PH-like	531..631	CDD:418428	48/99 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6674
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45023at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45110
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12156
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110