Protein Alignment CG5004 and PHLDB1

DIOPT Version :9

• Sequence 1: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Sequence 2: XP_011541005.1
• Gene: PHLDB1 / 23187
• HGNCID: 23697
• Length: 1586
• Species: Homo sapiens
• Alignment Length: 1662
• Identity: 366/1662 - (22%)
• Similarity: 576/1662 - (34%)
• Gaps: 570/1662 - (34%)

  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTI 65
            :.|.:....|:|....|||||||.||||||:|:..:..|.|.|||||. .|||.|.|:.|.||.|
Human    70 LDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAAR-DISLQGPGLAPEHCYI 133

  Fly    66 YRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAMGSNER 130
             .:....:||.| ..:...|||.|:.:.|:|:||.|:.:|.|.:||||:|.||:.|:|.:.:..|
Human   134 -ENLRGTLTLYP-CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR 196

  Fly   131 ISMPQIDFTQSARQAHELSQSLELESFYESIINPINNPSTYELECPKVFSSDLVTVNMPAKD--- 192
            ...|..             ..:..||  ||::|..:.|.| ....|...:|....|:...||
Human   197 APGPPY-------------SPVPAES--ESLVNGNHTPQT-ATRGPSACASHSSLVSSIEKDLQE 245

  Fly   193 -----VLGQKYASFARNLAENHRNEKQLNNQY---------AKGVGSNGGYWNV----------- 232
                 ||.:..|:..:..|.:..:......:|         |..|||:  |.|.
Human   246 IMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSS--YENTSPAFSPLSSPA 308

  Fly   233 ----------------PSNAAIYKEQHQQQH--QQAPQDLLTKVNNDRYDRYPKAGGLQIYSMNG 279
                            ||...:...:....|  .|.||...:...::. .|..:.||.:.....|
Human   309 SSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSES-PRLSRKGGHERPPSPG 372

  Fly   280 VNSDINNGPAT--------GNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSPI 336
            :...:.:.||.        ...|...|| :|..:....:||       |::..:|..:||..||.
Human   373 LRGLLTDSPAATVLAEARRATESPRLGG-QLPVVAISLSEY-------PASGALSQPTSIPGSPK 429

  Fly   337 VQ-------NRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVEINGQI 394
            .|       |:|   |:| :|:..|||.:               ..|.|.|....|:| ::.|:.
Human   430 FQPPVPAPRNKI---GTL-QDRPPSPFRE---------------PPGSERVLTTSPSR-QLVGRT 474

  Fly   395 HVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTKIRTNCMSPKKDV 459
            .          |.|:::..|.|..:.|.....|:...      :..|.||  .:....:||
Human   475 F----------SDGLATRTLQPPESPRLGRRGLDSMR------ELPPLSP--SLSRRALSP---- 517

  Fly   460 SFGNAFALAISPPPLASSAVVSTSKP--------------IPIPSMVKPPLAPKPP-----APNQ 505
                 .....:|.|..:..|..:.:|              :.:.:..:...:|.|.     ||::
Human   518 -----LPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHK 577

  Fly   506 QRDYEQLFKSF----------------ERKQQQLDRMVPAKRSNKN-INNLTLNLQSVESQTQSP 553
            .....:|..::                :||....|..||..|..|| |..::.|...:
Human   578 GSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDL------- 635

  Fly   554 KPSRKPAPAPRSIHLEQRQRRELIQRRKQLKR--------------------ELAELP------- 591
                      ...|..|||.|...|..::|:|                    |..|||
Human   636 ----------LEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATA 690

  Fly   592 --------PSAGIEGLELKLGEQP----------------------------------LAPSASP 614
                    ||.|:.|...:..|:|                                  .|||...
Human   691 ALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKL 755

  Fly   615 RLQLQALQN--------------RVCRLEAQ------------------RNATRVMEENQQAKLK 647
            :.::.||:.              ||..||.|                  |.|.|.:.:.:|..:.
Human   756 QGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVD 820

  Fly   648 Q----------------------------SIEIKQDQLKKLRAMLKQKPNNA--CLKEELQLVCE 682
            |                            .:|.:|....:|:..|...|.:.  .|:|:|:...|
Human   821 QLQEKLVALETGIQKERDKERAELAAGRRHLEARQALYAELQTQLDNCPESVREQLQEQLRREAE 885

  Fly   683 SLESDRKTFEDLEFQYFEEESEHHASHE-----------EF-----KRQEQRLMLEAELAALRIQ 731
            :||::.|.|||||||..|.||......|           |.     ||:|:..:|:::...:|.|
Human   886 ALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQ 950

  Fly   732 IGPDEEE-----------------------------PGSPTSPGST------------GSNLVNG 755
            ...:.|.                             .|....|.:|            .|.:..|
Human   951 AVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLG 1015

  Fly   756 VMSQSLF-GSAE--------------LLCPKRRN------------------------------Q 775
            ..:..|| ||::              |||||.:.                              .
Human  1016 TKALGLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASAS 1080

  Fly   776 EDLMSKSVNENMFYNHKIEANTSTPKR----LPL----QLFEDLAGGSCEQISFNLSLQGDRFEV 832
            .||:..:....|..:....:.|.:||.    ||.    |.:::|..|    :....:........
Human  1081 RDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAG----LGTGPAAASPHSSP 1141

  Fly   833 NPLERRVPSQDDIDRSCKVANDA----------PISASQGAST---------------------- 865
            .||..:...|..:.|| |:..:|          |:.:|.|:|:
Human  1142 PPLPAKASRQLQVYRS-KMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT 1205

  Fly   866 ---------KIFDSIMEIERNRKLLLAQQ---------------GHQVIEHERQKMYDLKKKSHD 906
                     .:..::.:||..|:|.|.|:               |.||||.:|:::.:||:|:..
Human  1206 QNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRRRLAELKQKAAA 1270

  Fly   907 EARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNVQ 971
            ||:.|:     .::.......:..:|  ...|...:.|..|      |...:    .|::..:..
Human  1271 EAQCQW-----DALHGAAPFPAGPSG--FPPLMHHSILHHL------PAGRE----RGEEGEHAY 1318

  Fly   972 NRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPLS 1036
            :..|..||.:..|:.:|||.:.      ..|:....|..|.:|            .:....:.|.
Human  1319 DTLSLESSDSMETSISTGGNSA------CSPDNMSSASGLDMG------------KIEEMEKMLK 1365

  Fly  1037 EANNCDATIEAPKFANGMDSSAS---PAVADNKRASSNSQDTASAGSGSGNSGSGGSTASDRKRV 1098
            ||:     .|..:.....:....   .|:.:.:|.....:....            |.::.|:::
Human  1366 EAH-----AEKNRLMESREREMELRRQALEEERRRREQVERRLQ------------SESARRQQL 1413

  Fly  1099 LPK----------HQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGAT 1153
            :.|          ..|||||||||...|.:|:.|||::||.:|.|.||.:.:..|||||.|:|..
Human  1414 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGK 1478

  Fly  1154 FHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHLNA------------SKSGR 1206
            ..:|.:||||.||.:..|.||.||.|.|.:|..||..|:|||.|||.:            ::|..
Human  1479 IKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPN 1543

  Fly  1207 PHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243
            |..||.|||..|.|.:.|.|..|.|||:|.|:|||:|
Human  1544 PALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEG 1580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899	27/62 (44%)
		PH-like	1142..1242	CDD:302622	50/111 (45%)
		PH	1143..1237	CDD:278594	47/105 (45%)
PHLDB1	XP_011541005.1	FHA	110..170	CDD:278899	27/62 (44%)
		DUF4584	<515..598	CDD:291876	11/91 (12%)
		CENP-F_leu_zip	722..865	CDD:287450	18/142 (13%)
		vATP-synt_E	785..>886	CDD:304907	14/100 (14%)
		PH_PHLDB1_2	1464..1579	CDD:270192	50/114 (44%)
		PH	1467..1574	CDD:278594	47/106 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2931
eggNOG	1	0.900	-	-		E1_2C17U
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2682
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47440
OrthoDB	1	1.010	-	-		D45023at33208
OrthoFinder	1	1.000	-	-		FOG0003925
OrthoInspector	1	1.000	-	-		otm40977
orthoMCL	1	0.900	-	-		OOG6_105283
Panther	1	1.100	-	-	LDO	PTHR12156
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6281
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.930