Protein Alignment CG5004 and Phldb1

DIOPT Version :10

• Sequence 1: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Sequence 2: XP_030099813.2
• Gene: Phldb1 / 102693
• MGIID: 2143230
• Length: 1642
• Species: Mus musculus
• Alignment Length: 1625
• Identity: 372/1625 - (22%)
• Similarity: 598/1625 - (36%)
• Gaps: 492/1625 - (30%)

  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTI 65
            :.|.:....|:|....|||||||.||||||:|:..:..|.|.|||||. .|||.|.|:.|.||.|
Mouse   122 LDLIETGQGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAAR-DISLQGPGLAPEHCYI 185

  Fly    66 YRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAM----- 125
             .:....:||.| ..:...|||.|:.:.|:|:||.|:.:|.|.:||||:|.||:.|:|.:
Mouse   186 -ENLRGTLTLYP-CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGVR 248

  Fly   126 --------GSNERISMPQIDFT-------QSARQAH-ELSQSLE--LESFYESII---------- 162
                    ||.|..|:...:.|       .||..:| .|..|:|  |:...:|::
Mouse   249 APGPTYNPGSAESESLVNGNHTAQPATRAPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKK 313

  Fly   163 -------NPINNPSTYELECPKVFSSDLVTVNMPAKDVLGQKYASFARNLAENHRNEKQLNNQYA 220
                   :|:.|...|.|..|          ..|....:|..|.:.:...:       .|::..:
Mouse   314 PAATSPLSPMANGGRYLLSPP----------TSPGAMSVGSSYENTSPAFS-------PLSSPAS 361

  Fly   221 KG---VGSNGGYWNVPSNAAIYKEQHQQQH--QQAPQDLLTKVNNDRYDRYPKAGGLQIYSMNGV 280
            .|   ..|..|....||...:...:....|  .|.||...:...:....|..:.||.:.....|:
Mouse   362 SGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGSRSSDSPRLGRKGGHERPPSPGL 426

  Fly   281 NSDINNGPA---------TGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSPI 336
            ...:.:.||         |..:...||  :|..:....:||       ||:...|..:||..||.
Mouse   427 RGLLTDSPAATVLAEARRTTESPRLGG--QLPVVAISLSEY-------PSSGARSQPASIPGSPK 482

  Fly   337 VQ-------NRIKTNGSLPRDKNKSPFPQQAG----VASSANISLL--SSSSGYENVRLLGP--- 385
            .|       |:|   |:| :|:..|||.:..|    :.||.:..|:  :.|.|....|.|.|
Mouse   483 FQSPVPAPRNKI---GTL-QDRPPSPFREPPGTERVLTSSPSRQLVGRTFSDGLAATRTLQPPES 543

  Fly   386 ---NRVEINGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTK 447
               .|..::....:|.      .|..:|..||:|..|..|....|::.         |.:|||.:
Mouse   544 PRLGRRGLDSMRELPP------LSPSLSRRALSPLPARTAPDPKLSRE---------VAESPRPR 593

  Fly   448 --------------------IRTNCMSPKKDVSFG---NAFALAISP--------------PPLA 475
                                .||...||....|..   .:|:..:||              .|.|
Mouse   594 RWAAHGTSPEDFSLTLGARGRRTRSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRA 658

  Fly   476 SSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQLDRM-------------- 526
            ...:.|....:|||...|..:.......::..:|.:..:....::|:::|:
Mouse   659 QRKLSSGDLRVPIPRERKNSITEISDNEDELLEYHRRQRQERLREQEMERLERQRLETILNLCAE 723

  Fly   527 ------------------------VPAKRSNKNINNLTL-------------------------- 541
                                    :..:|.::.:....:
Mouse   724 YSRADGGPETGELPSIGEATAALALAGRRPSRGLAGAIVVSGRCGEESGGASQRLWESMERSDEE 788

  Fly   542 NLQSVESQTQSPKPSRKPAPAPR---SIHLEQRQRRELIQRRKQLK-------RELAELPPSAGI 596
            ||:...|.|:|.:...:.||..:   .:...:.:|.:::.|.:|||       ::|.|....|.:
Mouse   789 NLKEECSSTESTQQEHEDAPGAKHQGEVLAVEEERAQVLGRVEQLKIRVKELEQQLQEAAREAEM 853

  Fly   597 EGLELKLGEQPLAPSASPRLQLQA---LQNRVCRLEAQRNATRVMEENQQAKLKQSIEIKQDQLK 658
            |...|: ||:. |..||.:.:.:|   ||.::..||......|..|..:.|..::.:|.:|....
Mouse   854 ERALLQ-GERE-AERASLQKEQRAVDQLQEKLVALETGIQKDRDKERAELAAGRRHLEARQALYA 916

  Fly   659 KLRAMLKQKPNNA--CLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHE----------- 710
            :|:..|...|.:.  .|:|:|:...::||::.|.|||||||..|.||......|
Mouse   917 ELQTQLDNCPESVREQLQEQLRREADALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKA 981

  Fly   711 -----EFKRQEQRLMLEAELAALRIQIGPDEEE-----------------------------PGS 741
                 ..||:|:..:|:::...:|.|...:.|.                             .|.
Mouse   982 ELLRSVSKRKERLAVLDSQAGQIRAQAVQESERLAREKNAALQLLQKEKEKLNVLERRYHSLTGG 1046

  Fly   742 PTSPGSTGS--------------NLVNGVMSQSLFGS-------------AELLCPKRRNQEDL- 778
            ...|.:|.:              .|....:.||...|             :..||||.:....|
Mouse  1047 RPFPKTTSTLKEAQLLISEASEIGLETKALGQSPRSSEAGASSVLLTPPASTQLCPKAQEYVTLE 1111

  Fly   779 ----------MSKSVNENM----FYNHKIEANTSTPKRLPL----------------------QL 807
                      |..|.:..:    ..:..:...|..|..||.                      |.
Mouse  1112 QLRVVWGTPPMPPSPSPGLPSWASASQDLAPITCLPPMLPSSFASITRSSKMEKLLLPAVDLEQW 1176

  Fly   808 FEDLAGGSCEQISFNLSLQGDRFEVNPLERRVPSQDDIDRSCKVANDA----------PISASQG 862
            :::|..|    :...|:....|....||..:...|..:.|| |:.:||          |:.:|.|
Mouse  1177 YQELMSG----LGTGLAAASPRSSPPPLPAKASRQLQVYRS-KMDSDAASPLPRTRSGPLPSSSG 1236

  Fly   863 AST-------------------------------KIFDSIMEIERNRKLLLAQQ----------- 885
            :|:                               .:..::.:||..|:|.|.|:
Mouse  1237 SSSSSSQLSVATLGRSPSPKSALLAQNGTSSLPRNLAATLQDIETKRQLALQQKVELPPAEPLPP 1301

  Fly   886 ----GHQVIEHERQKMYDLKKKSHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQK 946
                ||||||.:|:::.:||:|:..||:.|:     .::.......:..:|  ...|...:.|..
Mouse  1302 EDPAGHQVIEEQRRRLAELKQKAAAEAQCQW-----DALHGAGPFSAGPSG--FPALMHHSILHH 1359

  Fly   947 LNQKPGEPVDDQVQKIAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIAL 1011
            |      |...:    .|::..:..:..|..||.:..|:.:|||.:.      ..|:....|..|
Mouse  1360 L------PAGRE----RGEEGEHAYDTLSLESSDSMETSISTGGNSA------CSPDNMSSASGL 1408

  Fly  1012 GIGGGGSGGAGGANQMVARSPRPLSEANNCDATIEAPKFANGMDSSA-----------------S 1059
            .:|            .:....:.|.||:       |.| :..|:|..                 .
Mouse  1409 DMG------------KIEEMEKMLKEAH-------AEK-SRLMESRVRLTGARRQQVEREMELRR 1453

  Fly  1060 PAVADNKRASSNSQDTASAGSGSGNSGSGGSTASDRKRVLPK----------HQRPLTRYLPIFS 1114
            .|:.:.:|.....:....            |.::.|::::.|          ..||||||||...
Mouse  1454 QALEEERRRREQVERRLQ------------SESARRQQLVEKEVKLREKQFSQARPLTRYLPNRK 1506

  Fly  1115 PDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGATFHAWSRRWFVLDRQRSALIYYSDKSE 1179
            .|.:|:.|||::||.:|.|.||.:.:..|||||.|:|....:|.:||||.||.:..|.||.||.|
Mouse  1507 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLIKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHE 1571

  Fly  1180 RKPRGGAYFATIDEVYLDHL-NASKSGRPHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243
            .|.:|..||..|:|||.||| :|:||..|..||.|||..|.|.:.|.|..|.|||:|.|:|||:|
Mouse  1572 TKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEG 1636

  Fly  1244  1243
            Mouse  1637  1636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA_PHLB1	1..122	CDD:438765	54/120 (45%)
		SMC_N	<570..730	CDD:481474	49/187 (26%)
		Caldesmon	<664..801	CDD:460421	41/225 (18%)
		PH-like	1142..1242	CDD:473070	52/100 (52%)
Phldb1	XP_030099813.2	FHA_PHLB1	122..240	CDD:438765	54/120 (45%)
		PHA03307	251..>646	CDD:223039	90/439 (21%)
		Smc	<810..>1039	CDD:440809	52/230 (23%)
		PH_PHLDB1_2	1531..1635	CDD:270192	52/103 (50%)