DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5004 and Phldb1

DIOPT Version :9

Sequence 1:NP_573195.1 Gene:CG5004 / 32698 FlyBaseID:FBgn0260748 Length:1247 Species:Drosophila melanogaster
Sequence 2:XP_030099813.2 Gene:Phldb1 / 102693 MGIID:2143230 Length:1642 Species:Mus musculus


Alignment Length:1625 Identity:372/1625 - (22%)
Similarity:598/1625 - (36%) Gaps:492/1625 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTI 65
            :.|.:....|:|....|||||||.||||||:|:..:..|.|.|||||. .|||.|.|:.|.||.|
Mouse   122 LDLIETGQGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAAR-DISLQGPGLAPEHCYI 185

  Fly    66 YRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAM----- 125
             .:....:||.| ..:...|||.|:.:.|:|:||.|:.:|.|.:||||:|.||:.|:|.:     
Mouse   186 -ENLRGTLTLYP-CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGVR 248

  Fly   126 --------GSNERISMPQIDFT-------QSARQAH-ELSQSLE--LESFYESII---------- 162
                    ||.|..|:...:.|       .||..:| .|..|:|  |:...:|::          
Mouse   249 APGPTYNPGSAESESLVNGNHTAQPATRAPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKK 313

  Fly   163 -------NPINNPSTYELECPKVFSSDLVTVNMPAKDVLGQKYASFARNLAENHRNEKQLNNQYA 220
                   :|:.|...|.|..|          ..|....:|..|.:.:...:       .|::..:
Mouse   314 PAATSPLSPMANGGRYLLSPP----------TSPGAMSVGSSYENTSPAFS-------PLSSPAS 361

  Fly   221 KG---VGSNGGYWNVPSNAAIYKEQHQQQH--QQAPQDLLTKVNNDRYDRYPKAGGLQIYSMNGV 280
            .|   ..|..|....||...:...:....|  .|.||...:...:....|..:.||.:.....|:
Mouse   362 SGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGSRSSDSPRLGRKGGHERPPSPGL 426

  Fly   281 NSDINNGPA---------TGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSPI 336
            ...:.:.||         |..:...||  :|..:....:||       ||:...|..:||..||.
Mouse   427 RGLLTDSPAATVLAEARRTTESPRLGG--QLPVVAISLSEY-------PSSGARSQPASIPGSPK 482

  Fly   337 VQ-------NRIKTNGSLPRDKNKSPFPQQAG----VASSANISLL--SSSSGYENVRLLGP--- 385
            .|       |:|   |:| :|:..|||.:..|    :.||.:..|:  :.|.|....|.|.|   
Mouse   483 FQSPVPAPRNKI---GTL-QDRPPSPFREPPGTERVLTSSPSRQLVGRTFSDGLAATRTLQPPES 543

  Fly   386 ---NRVEINGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTK 447
               .|..::....:|.      .|..:|..||:|..|..|....|::.         |.:|||.:
Mouse   544 PRLGRRGLDSMRELPP------LSPSLSRRALSPLPARTAPDPKLSRE---------VAESPRPR 593

  Fly   448 --------------------IRTNCMSPKKDVSFG---NAFALAISP--------------PPLA 475
                                .||...||....|..   .:|:..:||              .|.|
Mouse   594 RWAAHGTSPEDFSLTLGARGRRTRSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRA 658

  Fly   476 SSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQLDRM-------------- 526
            ...:.|....:|||...|..:.......::..:|.:..:....::|:::|:              
Mouse   659 QRKLSSGDLRVPIPRERKNSITEISDNEDELLEYHRRQRQERLREQEMERLERQRLETILNLCAE 723

  Fly   527 ------------------------VPAKRSNKNINNLTL-------------------------- 541
                                    :..:|.::.:....:                          
Mouse   724 YSRADGGPETGELPSIGEATAALALAGRRPSRGLAGAIVVSGRCGEESGGASQRLWESMERSDEE 788

  Fly   542 NLQSVESQTQSPKPSRKPAPAPR---SIHLEQRQRRELIQRRKQLK-------RELAELPPSAGI 596
            ||:...|.|:|.:...:.||..:   .:...:.:|.:::.|.:|||       ::|.|....|.:
Mouse   789 NLKEECSSTESTQQEHEDAPGAKHQGEVLAVEEERAQVLGRVEQLKIRVKELEQQLQEAAREAEM 853

  Fly   597 EGLELKLGEQPLAPSASPRLQLQA---LQNRVCRLEAQRNATRVMEENQQAKLKQSIEIKQDQLK 658
            |...|: ||:. |..||.:.:.:|   ||.::..||......|..|..:.|..::.:|.:|....
Mouse   854 ERALLQ-GERE-AERASLQKEQRAVDQLQEKLVALETGIQKDRDKERAELAAGRRHLEARQALYA 916

  Fly   659 KLRAMLKQKPNNA--CLKEELQLVCESLESDRKTFEDLEFQYFEEESEHHASHE----------- 710
            :|:..|...|.:.  .|:|:|:...::||::.|.|||||||..|.||......|           
Mouse   917 ELQTQLDNCPESVREQLQEQLRREADALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKA 981

  Fly   711 -----EFKRQEQRLMLEAELAALRIQIGPDEEE-----------------------------PGS 741
                 ..||:|:..:|:::...:|.|...:.|.                             .|.
Mouse   982 ELLRSVSKRKERLAVLDSQAGQIRAQAVQESERLAREKNAALQLLQKEKEKLNVLERRYHSLTGG 1046

  Fly   742 PTSPGSTGS--------------NLVNGVMSQSLFGS-------------AELLCPKRRNQEDL- 778
            ...|.:|.:              .|....:.||...|             :..||||.:....| 
Mouse  1047 RPFPKTTSTLKEAQLLISEASEIGLETKALGQSPRSSEAGASSVLLTPPASTQLCPKAQEYVTLE 1111

  Fly   779 ----------MSKSVNENM----FYNHKIEANTSTPKRLPL----------------------QL 807
                      |..|.:..:    ..:..:...|..|..||.                      |.
Mouse  1112 QLRVVWGTPPMPPSPSPGLPSWASASQDLAPITCLPPMLPSSFASITRSSKMEKLLLPAVDLEQW 1176

  Fly   808 FEDLAGGSCEQISFNLSLQGDRFEVNPLERRVPSQDDIDRSCKVANDA----------PISASQG 862
            :::|..|    :...|:....|....||..:...|..:.|| |:.:||          |:.:|.|
Mouse  1177 YQELMSG----LGTGLAAASPRSSPPPLPAKASRQLQVYRS-KMDSDAASPLPRTRSGPLPSSSG 1236

  Fly   863 AST-------------------------------KIFDSIMEIERNRKLLLAQQ----------- 885
            :|:                               .:..::.:||..|:|.|.|:           
Mouse  1237 SSSSSSQLSVATLGRSPSPKSALLAQNGTSSLPRNLAATLQDIETKRQLALQQKVELPPAEPLPP 1301

  Fly   886 ----GHQVIEHERQKMYDLKKKSHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQK 946
                ||||||.:|:::.:||:|:..||:.|:     .::.......:..:|  ...|...:.|..
Mouse  1302 EDPAGHQVIEEQRRRLAELKQKAAAEAQCQW-----DALHGAGPFSAGPSG--FPALMHHSILHH 1359

  Fly   947 LNQKPGEPVDDQVQKIAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIAL 1011
            |      |...:    .|::..:..:..|..||.:..|:.:|||.:.      ..|:....|..|
Mouse  1360 L------PAGRE----RGEEGEHAYDTLSLESSDSMETSISTGGNSA------CSPDNMSSASGL 1408

  Fly  1012 GIGGGGSGGAGGANQMVARSPRPLSEANNCDATIEAPKFANGMDSSA-----------------S 1059
            .:|            .:....:.|.||:       |.| :..|:|..                 .
Mouse  1409 DMG------------KIEEMEKMLKEAH-------AEK-SRLMESRVRLTGARRQQVEREMELRR 1453

  Fly  1060 PAVADNKRASSNSQDTASAGSGSGNSGSGGSTASDRKRVLPK----------HQRPLTRYLPIFS 1114
            .|:.:.:|.....:....            |.::.|::::.|          ..||||||||...
Mouse  1454 QALEEERRRREQVERRLQ------------SESARRQQLVEKEVKLREKQFSQARPLTRYLPNRK 1506

  Fly  1115 PDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGATFHAWSRRWFVLDRQRSALIYYSDKSE 1179
            .|.:|:.|||::||.:|.|.||.:.:..|||||.|:|....:|.:||||.||.:..|.||.||.|
Mouse  1507 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLIKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHE 1571

  Fly  1180 RKPRGGAYFATIDEVYLDHL-NASKSGRPHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243
            .|.:|..||..|:|||.||| :|:||..|..||.|||..|.|.:.|.|..|.|||:|.|:|||:|
Mouse  1572 TKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEG 1636

  Fly  1244  1243
            Mouse  1637  1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5004NP_573195.1 FHA 41..104 CDD:278899 27/62 (44%)
PH-like 1142..1242 CDD:302622 52/100 (52%)
PH 1143..1237 CDD:278594 49/94 (52%)
Phldb1XP_030099813.2 FHA 162..222 CDD:395400 27/62 (44%)
PHA03307 251..>646 CDD:223039 90/439 (21%)
SMC_prok_B <743..>1034 CDD:274008 60/292 (21%)
PH_PHLDB1_2 1531..1635 CDD:270192 52/103 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 127 1.000 Domainoid score I5359
eggNOG 1 0.900 - - E1_2C17U
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47440
OrthoDB 1 1.010 - - D45023at33208
OrthoFinder 1 1.000 - - FOG0003925
OrthoInspector 1 1.000 - - otm43047
orthoMCL 1 0.900 - - OOG6_105283
Panther 1 1.100 - - LDO PTHR12156
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5713
SonicParanoid 1 1.000 - - X6281
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.910

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