DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5004 and phldb3

DIOPT Version :9

Sequence 1:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster
Sequence 2:	XP_002939188.2	Gene:	phldb3 / 100491291	XenbaseID:	XB-GENE-6045638	Length:	633	Species:	Xenopus tropicalis

Alignment Length:	837	Identity:	186/837 - (22%)
Similarity:	318/837 - (37%)	Gaps:	293/837 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 IPIP----SMVKPPLAP----------KPPAPNQQRDY-----EQLFKSFERKQQQLDRMVPAKR 531
            :|:|    :....|::|          :|||...:||.     .::..|.:.::......|||::
Frog    15 LPVPREPANQKTKPMSPERKSEEECRCEPPAEEVERDSVSSEGGRVTDSTDEEESSSTESVPAQQ 79

  Fly   532 SNKNINNLTLNLQSVESQTQSPKPSRKPAPAPRSIHLEQRQRRELIQRRK---QLKRELAELPPS 593
            .           ::|.::.|....:::.........|||..|...:|||:   :::.|:|.|...
Frog    80 E-----------KAVGNEVQRCLEAKQLKVMAHISKLEQSLRELQLQRRELNIEVEMEVALLEGE 133

  Fly   594 AGIEGLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVMEENQQAK-LKQSIEIKQDQL 657
            ...|..|:: .|:.|..|...:|:   ...|..:.|..::..::.:|.::.| |:|.|...:.||
Frog   134 LRTEKKEME-KEENLIRSLHEKLR---ETERKWQEEKDKDKLKLRDEKKKIKDLEQKISEGKSQL 194

  Fly   658 KKLRAMLKQKPNNACLKEELQLVCESLESDRKTFEDLEFQYFEEES----EHHASHEEF------ 712
            :|....|:::     |::.:|.:.|::|:..|:|||||||..|.||    |..:|:.:.
Frog   195 EKQPESLREQ-----LRKNIQEMTETMEAAVKSFEDLEFQQLESESSRDEERESSYRQISQDISK 254

  Fly   713 ------KRQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNGVMSQSLFGSAELLCPK 771
                  :|:::.|.||..:.....|...:.:.....           |..:.|||        .|
Frog   255 RQNELNRRKDKVLRLEEHIQGAEDQAQVERQRLSEE-----------NTRVFQSL--------NK 300

  Fly   772 RRNQEDLMSKSVNENMFYNHKIEANT--------STPKR-----------LPLQLFEDLAGGSCE 817
            .::|.:.::....::...|.|.:::|        |.|||           .||.|.    |.:|.
Frog   301 EKDQLESLNALSGKDQGQNEKPQSSTRKALQRTNSLPKRRASAPFVRPTDRPLSLH----GNTCL 361

  Fly   818 Q---ISFNLSLQGDR------FEVNP----LERRVPSQDDIDRSC--KVAND-APISASQGASTK 866
            :   ::.:|::..:.      ..::|    .:.|:|..||...|.  |:.:| :.:..|.|...|
Frog   362 ESAGLALHLAVSSNNTGGQIALAISPNLQITQARLPQVDDRKGSNREKIPSDISTLQLSYGPLPK 426

  Fly   867 IFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLKKKSHDEARTQYLLSTQQSMEQQRQLESDAN 931
                |.||||..:..||         |::::.    |:.:|.|.        :.|..|:|||
Frog   427 ----IAEIERQLREALA---------EKERLL----KAREEKRA--------AKEMTRRLES--- 463

  Fly   932 GGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQ 996

Frog   464 ----------------------------------------------------------------- 463

  Fly   997 QRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPLSEANNCDATIEAPKFANGMDSSASPA 1061
               ||                       ||:....|.|:                     :|.||
Frog   464 ---SQ-----------------------NQVKTEEPAPV---------------------TAKPA 481

  Fly  1062 VADNKRASSNSQDTASAGSGSGNSGSGGSTASDRKRVLPKHQRPLTRYLPIFSPDLNLRHHIETA 1126
            :.:.|                          .:.::||...:.|        :| |:||.|:|.:
Frog   482 LPETK--------------------------GEPEKVLSVLRAP--------AP-LDLRSHLEAS 511

  Fly  1127 GHQIDPCPHVFVDAHSCRGYLHKLGATFHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATI 1191
            ||.::.||||.|....|:|||.|:|.....|.:||||.|||:..|.||:||.|.|.:|..||..|
Frog   512 GHCVETCPHVRVSPTCCKGYLVKMGGRIKTWRKRWFVFDRQKRRLAYYTDKDEVKLKGVIYFQAI 576

  Fly  1192 DEVYLDHL-NASKSGRPHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQGNLDY 1247
            :|||.||| :|.||..|..||.:||.:|.:.:.|.:..|.|||:|.::|.|:.|..|
Frog   577 EEVYYDHLRSAFKSPHPKLTFCLKTFERLFCMVAPTPEAMRIWMDVMVTAAEENSRY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622	47/100 (47%)
		PH	1143..1237	CDD:278594	46/94 (49%)
phldb3	XP_002939188.2	Smc	<91..>332	CDD:224117	58/268 (22%)
phldb3	XP_002939188.2	PH-like	528..628	CDD:388408	47/99 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45023at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48175
Panther	1	1.100	-	-	O	PTHR12156
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5713
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.140