DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and AVT2

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_010850.1	Gene:	AVT2 / 856645	SGDID:	S000000790	Length:	480	Species:	Saccharomyces cerevisiae

Alignment Length:	511	Identity:	101/511 - (19%)
Similarity:	194/511 - (37%)	Gaps:	107/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FPARTQQQQSDQKAIEAAGEMGRTLEITGRQNDKSLEKNPERFTKNVTEKGADPENGDPVRRRGH 82
            ||..|.....|                 |.|...||        ..:|....|....|.:|....
Yeast    26 FPGTTDNDSDD-----------------GSQGQNSL--------NIITPDMDDTLVNDVLRENDK 65

  Fly    83 ETSELEAATHLFKGSVGAGLFAMGDCFKNGGLAGATILLPIIAVMCVHCERMLIRGSVLAVERTP 147
            ::|...|..:|....:|||:.......||.|:.|..:....:..:.....|:::....||.:||
Yeast    66 KSSMRMAFMNLANSILGAGIITQPFAIKNAGILGGLLSYVALGFIVDWTLRLIVINLTLAGKRT- 129

  Fly   148 GVDFLDYPETVEKCFEHGPRPLRKMSRVMKLIVEMFLCVTQFGFCAIYFVFITE----------- 201
                  |..|||          ..|.:..||::.....:..||.|..|.:.|.:
Yeast   130 ------YQGTVE----------HVMGKKGKLLILFTNGLFAFGGCIGYCIIIGDTIPHVLRAIFS 178

  Fly   202 ----NLHQVLQQNGIVISMSMVMLITLLPAMIPSLMTNLKYISPVSLFANVALLFGLIATLTIAF 262
                |:|..|::|.|::      ::|...:...|:..|::.:|..|..|.:::   :|..||:..
Yeast   179 QNDGNVHFWLRRNVIIV------MVTTFISFPLSMKRNIEALSKASFLAVISM---IIIVLTVVI 234

  Fly   263 SDGPM-PSVGDRHLFTGGAQLALFF------------GTALFSYEGIALI-LPLRNSMRRPEKFS 313
            . ||| |.....|    ..:|:.||            ..||..:...:.| ..:||  |...||:
Yeast   235 R-GPMLPYDWKGH----SLKLSDFFMKATIFRSLSVISFALVCHHNTSFIFFSMRN--RSVAKFT 292

  Fly   314 --TRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEVFSQVVKVIAALGVFLGYP 376
              |...::.|.:  ..||..::||..:   .|:..|::..:....:....:.::.....:...:|
Yeast   293 RLTHISIIISVI--CCALMGYSGFAVF---KEKTKGNVLNSFPGTDTAINIARLCFGFNMLTTFP 352

  Fly   377 IQFFVMIKILWPPLKRSN---NCTQKYPITSQ--VCLRFFMVMMTFGVALVVPKLNLFISLIGAL 436
            ::.||:..::...|...|   |..:...::.:  |.:...:|.:|.|::|....|.....||||.
Yeast   353 MEIFVLRDVVGNLLHECNLIKNYDEHTQLSGKQHVVITSSLVFITMGISLTTCNLGALFELIGAT 417

  Fly   437 CSTCLAFVIPVLIDFVT-------RAQVPKALGV-WSYIKNILILTVAVLGIVTGT 484
            .::.:|:::|...:.:.       :.::|..|.: :.::..|:..|..::..|.|:
Yeast   418 TASTMAYILPPYTNLLLTSKKKSWKERLPFYLCICFGFMIMIISSTQTIIDAVNGS 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	89/447 (20%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	89/445 (20%)
AVT2	NP_010850.1	Aa_trans	65..467	CDD:279788	87/439 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920