DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and AVT4

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_014298.1	Gene:	AVT4 / 855622	SGDID:	S000005045	Length:	713	Species:	Saccharomyces cerevisiae

Alignment Length:	548	Identity:	126/548 - (22%)
Similarity:	226/548 - (41%)	Gaps:	118/548 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RTQQQQSDQKAIEAAGEMGRTLEITGRQNDKSLEKNP------------------ERF------- 60
            |.:.|.:|..:.:.......::..:...:::.::|.|                  |.|
Yeast   201 RQEHQLNDSASSDFTSHESDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPD 265

  Fly    61 TKNVTEKGADPENGDPVRRRGH---------ETSELEAATHLFKGSVGAGLFAMGDCFKNGGLAG 116
            :.|:..:|.| |....:.|..|         .||..:....|.|..:|.|:..:.:.|.||||..
Yeast   266 SSNMMIRGED-ERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFF 329

  Fly   117 ATILLPIIAVMCVHCERMLIRGSVLAVERTPGVDFLDYPETVEKCFEHGPRPLRKMSRVMKLIVE 181
            :..:|....:....|..:|::     .:.:.||.            ..|...|:.....|::|:.
Yeast   330 SVSMLAFFGIYSYWCYYILVQ-----AKSSCGVS------------SFGDIGLKLYGPWMRIIIL 377

  Fly   182 MFLCVTQFGFCAIYFVFITENLHQVLQQ--NGIVISMSMVMLITLLPAMIPSLMTNLKYISPVSL 244
            ..|.:||.||...|.:|..:||...|..  :..|:.:|.:|:...:..:..|.:.|:..:|..||
Yeast   378 FSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSL 442

  Fly   245 FANVALLFGLIATLTIAFSDGPM-------PSVG-------DRHLFTGGAQLALFFGTALFSYEG 295
            .||..::.||:  :.|.|:...:       |::|       ||        ..||.|||:|::||
Yeast   443 LANFFIMAGLV--IVIIFTAKRLFFDLMGTPAMGVVYGLNADR--------WTLFIGTAIFAFEG 497

  Fly   296 IALILPLRNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEVFS 360
            |.||:|:::|||.||||..   ||...:...|.|||....:.|:.:|..|...|.|||....:|.
Yeast   498 IGLIIPVQDSMRNPEKFPL---VLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFV 559

  Fly   361 QVVKVIAALGVFLGYPIQFFVMIKILWPPLKRSNNCTQKY--------PITSQV----------- 406
            .::::..::.:.|..|:|.|..|||:      .|....|:        .:|::|
Yeast   560 NLIQLFYSIAIMLSTPLQLFPAIKII------ENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNW 618

  Fly   407 -------CLRFFMVMMTFGVALV-VPKLNLFISLIGALCSTCLAFVIPVLIDFVTRAQVPKALGV 463
                   .:|..:|::...:|.. ...|:.|:|:||:|....|.::.|.:: .:....:|:..|.
Yeast   619 KIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSML-HLRGNSLPETKGE 682

  Fly   464 WSYIKNILILTVAVLGIVT---GTYQSI 488
            :...|.:|...:...||.:   .:||||
Yeast   683 FWRFKPMLDTILIFFGIASMLYTSYQSI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	114/462 (25%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	111/449 (25%)
AVT4	NP_014298.1	Aa_trans	295..711	CDD:279788	113/453 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
TreeFam	0	0.000	Not matched by this tool.
	7	6.960