DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and SLC38A7

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001356537.1	Gene:	SLC38A7 / 55238	HGNCID:	25582	Length:	462	Species:	Homo sapiens

Alignment Length:	498	Identity:	118/498 - (23%)
Similarity:	195/498 - (39%)	Gaps:	114/498 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AGEMGRTLEITGRQNDKSLEKNPERFTKNVTEKGADPENGDPVRRRGHETSELEAATHLFKGSVG 99
            |||..|.|:            :|...|...:|..|.|...|    || .||.|.|...:....:|
Human    19 AGERARLLQ------------SPCVDTAPKSEWEASPGGLD----RG-TTSTLGAIFIVVNACLG 66

  Fly   100 AGLFAMGDCFKNGGLAGATILLP------IIA--VMCVHCERMLIRGSVLAVERTPGVDFLDYPE 156
            |||......|...|...|.|.|.      ||:  |:..:|       |..:.|||       |.|
Human    67 AGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYC-------SQASNERT-------YQE 117

  Fly   157 TV-EKCFEHGPRPLRKMSRVMKLIVEMFLCVTQFGFCAIYFVFITENLHQVLQQNGIV------- 213
            .| ..|           .::..::.|:.:.|..||.|..:.:.|.:      ||:.|:
Human   118 VVWAVC-----------GKLTGVLCEVAIAVYTFGTCIAFLIIIGD------QQDKIIAVMAKEP 165

  Fly   214 ------------ISMSMVMLITLLPAMIPSLMTNLKYISPVSLFANVALLFGLIATLTIAFSDGP 266
                        .::|:...:.:||..||..:...||.|    |.:|...:.:.|.:.|.:. .|
Human   166 EGASGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYAS----FLSVVGTWYVTAIVIIKYI-WP 225

  Fly   267 MPSVGDRHLFTGGAQ-LALF--FGTALFSYEGIALILPLRNSMRRPEKFSTRFGVLNSTMFFTTA 328
            ...:...::.|..|. :|:|  ..|..|.::.....:|:.|||::|| ..|..||:.:.|....|
Human   226 DKEMTPGNILTRPASWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPE-VKTWGGVVTAAMVIALA 289

  Fly   329 LFIFTGFVSYVRWGEEVAGSITLNLVVEEVFSQVVKVIAALGVFLGYPIQFF---VMIKILWPPL 390
            :::.||...::.:|..|...:.|:...|::...|.:....|.|...|||..|   .:::.||  |
Human   290 VYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLW--L 352

  Fly   391 KRSNNCTQKYPITSQV----------CLRFFMVMMTFGVALVVPKLNLFISLIGALCSTCLAFVI 445
            :     .|..|:...|          .|.:|  ::|..:||.:|.:...||:||.| :.|..||.
Human   353 R-----YQGVPVEEDVGRERRRRVLQTLVWF--LLTLLLALFIPDIGKVISVIGGL-AACFIFVF 409

  Fly   446 PVLIDF---VTRAQVPKALGVWSYIK-NILILTVA--VLGIVT 482
            |.|...   ::..:..|....|..:. .:|::|:.  :.|..|
Human   410 PGLCLIQAKLSEMEEVKPASWWVLVSYGVLLVTLGAFIFGQTT 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	105/451 (23%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	105/449 (23%)
SLC38A7	NP_001356537.1	SLC5-6-like_sbd	49..457	CDD:320982	106/452 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4217
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D697331at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.810