DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and SLC38A4

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001137296.1	Gene:	SLC38A4 / 55089	HGNCID:	14679	Length:	547	Species:	Homo sapiens

Alignment Length:	501	Identity:	94/501 - (18%)
Similarity:	187/501 - (37%)	Gaps:	152/501 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 HLFKGSVGAGLFAMGDCFKNGGLAGATILLPIIAVMCVHCERMLIR-----GSVLAVERTPGVDF 151
            :|....:|:|:..:.....|.|:....|:|..:|::.::...:|::     ||::
Human    83 NLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLKTAKEGGSLI---------- 137

  Fly   152 LDYPETVEKCFEHGPRPLRKMSRVMKLIVEM--FLCVTQFGFCAIY--FVFITENLHQ-VLQQNG 211
              |.:..||.|....:....:|..|:.|..|  :|.:.::....:.  |:.:.||..: .|..|.
Human   138 --YEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNY 200

  Fly   212 IVISMSMVMLITLLPAMIPSLMTNLKYISPVSLFANVALLFGLIATLTIAFS-DGPMP----SVG 271
            ::|.:|:.:::.|      ||:.||.|:...|.|:...::|.:...:...|. ..|:|    |||
Human   201 LIIFVSVGIILPL------SLLKNLGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVG 259

  Fly   272 DRHLFTGGAQLALFFGTALFSYEGIALILPLRNS------------MRRP--------------- 309
            :           |.|...|..:   .::|| .||            .|.|
Human   260 N-----------LSFNNTLPMH---VVMLP-NNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDS 309

  Fly   310 ---------EKFSTRFGVLNSTMFFTTALFIFTGFVSYVR----WGE---------------EVA 346
                     :|...::.|.||...:...:.:| .||.:..    :.|               .:.
Human   310 GVEYEAHSDDKCEPKYFVFNSRTAYAIPILVF-AFVCHPEVLPIYSELKDRSRRKMQTVSNISIT 373

  Fly   347 GSITLNLV------------VEE----VFSQV---------VKVIAALGVFLGYPIQFF----VM 382
            |.:.:.|:            ||:    .:|:|         |::...:.|.|..||..|    .:
Human   374 GMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSV 438

  Fly   383 IKILWPPLKRSNNCTQKYPITSQVCLRFFMVMMTFGVALVVPKLNLFISLIGALCSTCLAFVIPV 447
            |.:|:|  ||..:..:.:.|.:      .::.:...:.::||.:......|||..:|.|.|::|.
Human   439 ITLLFP--KRPFSWIRHFLIAA------VLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPA 495

  Fly   448 L--IDFVTRA--QVPKALGVWSYIKNILILTVAVLGIVTGTYQSIV 489
            :  :..|.:.  :.|:.:|.       ||..|..:..:.|:...|:
Human   496 VFYLKLVKKETFRSPQKVGA-------LIFLVVGIFFMIGSMALII 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	93/499 (19%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	93/498 (19%)
SLC38A4	NP_001137296.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		SdaC	71..534	CDD:223884	93/499 (19%)
		SLC5-6-like_sbd	73..535	CDD:294310	94/501 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D697331at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860