Protein Alignment CG4991 and SLC38A2

DIOPT Version :9

• Sequence 1: NP_001259638.1
• Gene: CG4991 / 32695
• FlyBaseID: FBgn0030817
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_061849.2
• Gene: SLC38A2 / 54407
• HGNCID: 13448
• Length: 506
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 99/535 - (18%)
• Similarity: 195/535 - (36%)
• Gaps: 135/535 - (25%)

  Fly    37 EMGRTLEITGRQNDKSLEKNPERFTKNVTEKGA--------DPENGD-----PVRRRGHETSELE 88
            |||| ..|:..::..|...|.:......|::.|        ||||.:     .:.::.:|| |..
Human     5 EMGR-FSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYET-EFH 67

  Fly    89 AAT--------HLFKGSVGAGLFAMGDCFKNGGLAGATILLPIIAVMCVHCERMLIR-----GSV 140
            ..|        :|....||:|:..:.....|.|:|...|||..:::..::...:|::     ||:
Human    68 PGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSL 132

  Fly   141 LAVERTPGVDFLDYPETVEKCFEHGPRPLRKMSRVMKLIVEMFLCVTQFGFCAIYFVFITENLHQ 205
            |            |.:...|.|          ..|.||.....:.:...|..:.|...:...|..
Human   133 L------------YEQLGYKAF----------GLVGKLAASGSITMQNIGAMSSYLFIVKYELPL 175

  Fly   206 VLQQ---------------NGIVISMSMVMLITLLPAMIPSLMTNLKYISPVSLFANVALLFGLI 255
            |:|.               |.:|:.:|:|:::.|      ||..||.|:...|..:.:.::|.||
Human   176 VIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPL------SLFRNLGYLGYTSGLSLLCMVFFLI 234

  Fly   256 ATL----------------------TIAFSDGPMPSVGDR---------HLFTGGAQLALFFGTA 289
            ..:                      |:......:|::...         |.|...:|........
Human   235 VVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPIL 299

  Fly   290 LFSYEGIALILPLRNSMRRPEKFSTRFGVLNSTMFFTTAL-FIFTGFVSYVRWGEEVAGSIT--- 350
            :||:.....:||:...::  ::...|...::...||...| ::......|:.:.|.|...:.
Human   300 IFSFVCHPAVLPIYEELK--DRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTY 362

  Fly   351 LNLVVEEVFSQVVKVIAALGVFLGYPIQFFVMIKILWPPLKRSNN---CTQK------YPITSQV 406
            .:::..::...:|::...:.|.|..|:..|        |::.|..   |..|      :.:.:..
Human   363 SSILGTDILLLIVRLAVLMAVTLTVPVVIF--------PIRSSVTHLLCASKDFSWWRHSLITVS 419

  Fly   407 CLRFFMVMMTFGVALVVPKLNLFISLIGALCSTCLAFVIP-----VLIDFVTRAQVPKALGVWSY 466
            .|.|..:::.|     ||.:......|||..::.|.|::|     .|:.......|.|...::..
Human   420 ILAFTNLLVIF-----VPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFL 479

  Fly   467 IKNILILTVAVLGIV 481
            :..:|::|.::..||
Human   480 LSGVLVMTGSMALIV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	86/477 (18%)
		SdaC	84..488	CDD:223884	85/475 (18%)
SLC38A2	NP_061849.2	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..96		21/92 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/18 (33%)
		SLC5-6-like_sbd	69..495	CDD:320982	83/469 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850