DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and CG1139

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_647686.1	Gene:	CG1139 / 38264	FlyBaseID:	FBgn0035300	Length:	451	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	143/458 - (31%)
Similarity:	236/458 - (51%)	Gaps:	18/458 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ND--KSLEKNPERFTKNVTEKGADPENG--DPVRRR--GHETSELEAATHLFKGSVGAGLFAMGD 107
            ||  |::...|.........|.|:..|.  ||.:.|  .:.|:..:...|..|.|||.|:.||..
  Fly     2 NDDIKTVTVYPTTLELTTPTKSANGSNDDYDPHQHRELKNPTTNFQTFAHFLKASVGTGVLAMPS 66

  Fly   108 CFKNGGLAGATILLPIIAVMCVHCERMLIRGSVLAVERTPGVDFLDYPETVEKCFEHGPRPLRKM 172
            .|.:.|....|:|..||..:.::|..:||:...:..:| ..|.::.:.:.:....:.||..||.:
  Fly    67 AFAHAGYVNGTLLTLIIGSLALYCLHILIKCMYILCKR-QRVPYVSFSQAMNLGLKQGPPWLRCL 130

  Fly   173 SRVMKLIVEMFLCVTQFGFCAIYFVFITENLHQVLQQNGIVISMSMVMLITLLPAMIPSLMTNLK 237
            :.:....|:.||....||.|.:|.|||.|::.|::.:..:|..:.:.|.|.::|.::...:.|||
  Fly   131 APIAVPFVDGFLAFYHFGICCVYVVFIAESIKQLVDEYLVVWDVRIHMCIIIVPLLLIYSIKNLK 195

  Fly   238 YISPVSLFANVALLFGLIATLTIAFSDGPMPSVGDRHLFTGGAQLALFFGTALFSYEGIALILPL 302
            .::|.|..||:.||.|....|...|.:  :|.:.:|..|....:|..||||.||:.|.:.:||.:
  Fly   196 LLAPFSSAANLLLLVGFGIILYYIFEE--LPPLSERDPFVAAGKLPTFFGTVLFALEAVGVILAI 258

  Fly   303 RNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEVFSQVVKVIA 367
            ..:|..|:.|....|:|||.|.....|::..||..|.::|.|..||||||:...|:.:|||||..
  Fly   259 EENMATPKSFVGPCGILNSGMSIVLGLYVLLGFFGYWKYGNESEGSITLNIPQSEIPAQVVKVFF 323

  Fly   368 ALGVFLGYPIQFFVMIKILWPP--LKRSNNCTQKYPITSQVCLRFFMVMMTFGVALVVPKLNLFI 430
            |:..::.|.:|.:|...|||..  .||.....|.:   .::..|..:|::|||.|:.:|.|::|:
  Fly   324 AITTWISYALQGYVTAHILWDKYLAKRFKETRQTF---YELIFRAIIVLLTFGCAVAIPDLSVFL 385

  Fly   431 SLIGALCSTCLAFVIPVLIDFVTRAQVPKALGVW--SYIKNILILTVAVLGIVTGTYQSIVEIVK 493
            ||:|:.|.:.|..:.|||:...  .|..:..|.:  ..|.|:|:|...:.|.|.|||.||::|:.
  Fly   386 SLVGSFCLSILGLIFPVLLQIC--VQYTEGYGPFRIKLIINLLLLCFGIFGGVVGTYVSILDIIA 448

  Fly   494 EFK 496
            .:|
  Fly   449 VYK 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	130/410 (32%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	129/407 (32%)
CG1139	NP_647686.1	SdaC	36..404	CDD:223884	118/373 (32%)
CG1139	NP_647686.1	SLC5-6-like_sbd	42..444	CDD:294310	130/409 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468300
Domainoid	1	1.000	157	1.000	Domainoid score	I1306
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1622
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm1178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
	9	9.000