DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and polyph

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_610631.1	Gene:	polyph / 36161	FlyBaseID:	FBgn0033572	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	123/468 - (26%)
Similarity:	210/468 - (44%)	Gaps:	44/468 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QNDKSLEKNPERFTKNVTEKGADPENGDPVRRRGHET--SELEAATHLFKGSVGAGLFAMGDCFK 110
            ::|..|:..|....:::|..    ...:|..:|..|.  :..:|...|.|..:|.|:.||...|:
  Fly    12 RDDPDLQTEPLTIAQSITSF----YMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFR 72

  Fly   111 NGGLAGAT---ILLPIIAVMCVH---------CERMLIRGSVLAVERTPGVDFLDYPETVEKCFE 163
            ..|....|   |||.|:....:|         |.|          .|.|.|..   ||.|...:|
  Fly    73 CSGFVMGTVMSILLMILLTYSIHLLIADMTECCRR----------RRVPQVSM---PEAVRIAYE 124

  Fly   164 HGPRPLRKMSRVMKLIVEMFLCVTQFGFCAIYFVFITENL-----HQVLQQNGIVISMSMVMLIT 223
            .||:.:....|....:....|...||..|.:|.||:::|.     |.:.:.|...  ..:|..:.
  Fly   125 EGPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIERYNERY--YVLVACLL 187

  Fly   224 LLPAMIPSLMTNLKYISPVSLFANVALLFGLIATLTIAFSDGPMPSVGDRHLFTGGAQLALFFGT 288
            |||..   ::..|||:.|::|.:|..|..|....:...|:.  :|::.||.:.|...:...|...
  Fly   188 LLPLF---MIRRLKYLVPLNLISNFLLYAGFALIMYYLFNG--LPNINDREMVTPPVEWIEFIAI 247

  Fly   289 ALFSYEGIALILPLRNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNL 353
            |.||...:..:|.:...|..|:.:...|||||..:.|.....:|.|.:.|.|:|:.|..|||||:
  Fly   248 AAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASITLNI 312

  Fly   354 VVEEVFSQVVKVIAALGVFLGYPIQFFVMIKILWPPLKRSNNCTQKYPITSQVCLRFFMVMMTFG 418
            ..:|:.||.:||..|.|:||.||:..||:|.:::...:.|.. ..:|....:..:|...:.:|..
  Fly   313 PQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEP-RGRYRTLIEYVVRLLFLFLTGA 376

  Fly   419 VALVVPKLNLFISLIGALCSTCLAFVIPVLIDFVTRAQVPKALGVWSYIKNILILTVAVLGIVTG 483
            ||:.||.|.....|.||...:.|..:.|.|||......|.....:|..|::||::.:.::..:.|
  Fly   377 VAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVG 441

  Fly   484 TYQSIVEIVKEFK 496
            ...::::::::|:
  Fly   442 CTVALMQLIRDFQ 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	116/425 (27%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	115/422 (27%)
polyph	NP_610631.1	SLC5-6-like_sbd	50..407	CDD:320982	106/377 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468299
Domainoid	1	1.000	157	1.000	Domainoid score	I1306
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1622
Isobase	1	0.950	-	0	Normalized mean entropy	S4217
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm1178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
	11	10.960