DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and SLC36A3

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001138489.1	Gene:	SLC36A3 / 285641	HGNCID:	19659	Length:	511	Species:	Homo sapiens

Alignment Length:	514	Identity:	137/514 - (26%)
Similarity:	245/514 - (47%)	Gaps:	83/514 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LEITGRQNDKSLE------KNPERFTKNVTEKGADPENGDPVRRRGHETSELEAATHLFKGSVGA 100
            :.:.||..:..|.      ::|...:.::|.     ||..|....|  .|.::...||.|.::|.
Human     1 MSLLGRDYNSELNSLDNGPQSPSESSSSITS-----ENVHPAGEAG--LSMMQTLIHLLKCNIGT 58

  Fly   101 GLFAMGDCFKNGGLAGATILLPIIAVMCVHCERMLIRGSVLAVERTPGVDFLDYPET----VEKC 161
            ||..:....||.||....:.|..|.|:.|||..:|:..:....:|.... |::|.|.    :|.|
Human    59 GLLGLPLAIKNAGLLVGPVSLLAIGVLTVHCMVILLNCAQHLSQRLQKT-FVNYGEATMYGLETC 122

  Fly   162 --------------------------------------FEHGPRPLRKMSRVMKLIVEMFLCVTQ 188
                                                  ..:.|....:::.:.:..|...|.:||
Human   123 PNTWLRAHAVWGRWNLALSPRLECSGKISAHCNPHLQGSSNSPAQASRVAGIYRYTVSFLLVITQ 187

  Fly   189 FGFCAIYFVFITENLHQVLQQNGI---------------VISMSMVMLITLLPAMIPSLMTNLKY 238
            .|||::||:|:.:||.|::::..:               ::.:...|||.|...::...:.|||.
Human   188 LGFCSVYFMFMADNLQQMVEKAHVTSNICQPREILTLTPILDIRFYMLIILPFLILLVFIQNLKV 252

  Fly   239 ISPVSLFANVALLFGLIATLTIAFSDG-PMPSVGDRHLFTGGAQLALFFGTALFSYEGIALILPL 302
            :|..|..||:..| |.:|.:.....:| |.||  :..|........||||||:|::||:.::|||
Human   253 LSVFSTLANITTL-GSMALIFEYIMEGIPYPS--NLPLMANWKTFLLFFGTAIFTFEGVGMVLPL 314

  Fly   303 RNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEVFSQVVKVIA 367
            :|.|:.|::||.   ||...|.....|:|..|.:.|:::|.:...||||||....:: |.||::.
Human   315 KNQMKHPQQFSF---VLYLGMSIVIILYILLGTLGYMKFGSDTQASITLNLPNCWLY-QSVKLMY 375

  Fly   368 ALGVFLGYPIQFFVMIKILWPPLKRSNNCTQKYPITSQVCLRFFMVMMTFGVALVVPKLNLFISL 432
            ::|:|..|.:||.|..:|:.|  ...:..::.:.:...:.:|..:|.:|...|:::|:|:|.|||
Human   376 SIGIFFTYALQFHVPAEIIIP--FAISQVSESWALFVDLSVRSALVCLTCVSAILIPRLDLVISL 438

  Fly   433 IGALCSTCLAFVIPVLIDFVTRAQVPKALGVWSYIKNILILTVAVLGIVTGTYQSIVEI 491
            :|::.|:.||.:||.|::.|  ....:.:...:..|:|:|..|.:||.:.||||::.|:
Human   439 VGSVSSSALALIIPALLEIV--IFYSEDMSCVTIAKDIMISIVGLLGCIFGTYQALYEL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	127/464 (27%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	127/461 (28%)
SLC36A3	NP_001138489.1	SLC5-6-like_sbd	41..492	CDD:320982	128/464 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960