DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and Slc36a2

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_694810.2	Gene:	Slc36a2 / 246049	MGIID:	1891430	Length:	478	Species:	Mus musculus

Alignment Length:	460	Identity:	135/460 - (29%)
Similarity:	234/460 - (50%)	Gaps:	40/460 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PERFTKNVTEKGADPENGDPVRRRGHETSE-------LEAATHLFKGSVGAGLFAMGDCFKNGGL 114
            ||. .|.:..:...|.||.     ..|:|:       .:...||.||::|.|:..:....||.|:
Mouse    21 PES-AKKLQSQDPSPANGS-----SSESSKKTKGITGFQTLVHLVKGNMGTGILGLPLAVKNAGI 79

  Fly   115 AGATILLPIIAVMCVHCERMLIRGSVLAVERTPGVDFLDYPETVEKCFEHGPRP-LRKMSRVMKL 178
            ....:.|.::.::..||..:|:|.:.....|. ...|:||.:||.......|.. |:..:...:.
Mouse    80 LMGPLSLLVMGLIACHCMHILVRCAQRFCHRL-NKPFMDYGDTVMHGLAFSPNAWLQNHAHWGRR 143

  Fly   179 IVEMFLCVTQFGFCAIYFVFITENLHQVLQQ-NGIVISMSMVMLITLLPAM---------IPSL- 232
            :|..||.|||.|||.:|.||:.:||.||::. |...||......:.|.|.|         :|.|
Mouse   144 VVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTISCHKNETVVLTPTMDSRLYMLSFLPVLG 208

  Fly   233 ----MTNLKYISPVSLFANVALLFGLIATLTIAFSDGPMPSVGDRHLFTGGAQLALFFGTALFSY 293
                :.||:.::..||.||:::|..|:........:  :|......|........||||||:||:
Mouse   209 LLVFVRNLRVLTIFSLLANISMLVSLVIIAQYIIQE--IPDASQLPLVASWKTYPLFFGTAIFSF 271

  Fly   294 EGIALILPLRNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEV 358
            |.|.::|||.|.|:....|.|   :|:..|...|.|:|..|.:.|:|:|:::..||||||....:
Mouse   272 ESIGVVLPLENKMKDARGFPT---ILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPNCWL 333

  Fly   359 FSQVVKVIAALGVFLGYPIQFFVMIKILWPPLKRSNNCTQKYPITSQVCLRFFMVMMTFGVALVV 423
            : |.||::..:|:...|.:||:|..:|:.|  ...:..::::.:...:.:|..:|.:|..:|:::
Mouse   334 Y-QSVKLLYVVGILCTYALQFYVPAEIIIP--LAVSQVSKRWALPVDLSIRLALVCLTCMLAILI 395

  Fly   424 PKLNLFISLIGALCSTCLAFVIPVLIDFVTRAQVPKALGVWSYIKNILILTVAVLGIVTGTYQSI 488
            |:|:|.:||:|::.|:.||.:||.|::.||  ...:.:...:..|:.||..:..:|.|.||||::
Mouse   396 PRLDLVLSLVGSVSSSALALIIPPLLEVVT--YYGEGISPLTVTKDALISILGFMGFVVGTYQAL 458

  Fly   489 VEIVK 493
            .|::|
Mouse   459 DELIK 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	127/429 (30%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	126/426 (30%)
Slc36a2	NP_694810.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		8/30 (27%)
Slc36a2	NP_694810.2	SLC5-6-like_sbd	48..458	CDD:294310	125/420 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960