DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4991 and SLC36A2

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_861441.2	Gene:	SLC36A2 / 153201	HGNCID:	18762	Length:	483	Species:	Homo sapiens

Alignment Length:	462	Identity:	133/462 - (28%)
Similarity:	237/462 - (51%)	Gaps:	39/462 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NPERFTKNVTEKGADPENGDPVRRRGHETSE----LEAATHLFKGSVGAGLFAMGDCFKNGGLAG 116
            :|....|.:..|.:...:..|....|.:.::    .:|..||.||::|.|:..:....||.|:..
Human    22 SPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKNAGILM 86

  Fly   117 ATILLPIIAVMCVHCERMLIRGSVLAVERTPGVDFLDYPETVEKCFEHGPRP-LRKMSRVMKLIV 180
            ..:.|.::..:..||..:|::.:....:|. ...|:||.:||....|..|.. |:..:...:.||
Human    87 GPLSLLVMGFIACHCMHILVKCAQRFCKRL-NKPFMDYGDTVMHGLEANPNAWLQNHAHWGRHIV 150

  Fly   181 EMFLCVTQFGFCAIYFVFITENLHQVLQ----------QNGIVISM----SMVMLITLLPAMI-P 230
            ..||.:||.|||.:|.||:.:||.||::          .|..||..    |.:.:::.||.:: .
Human   151 SFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLL 215

  Fly   231 SLMTNLKYISPVSLFANVALLFGLIATLTIAFSDGPMPSVGDRHLFTGGAQLALFFGTALFSYEG 295
            .|:.||:.::..|:.||:::|..|:..:.....:.|.||  ...|........||||||:||:|.
Human   216 VLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPS--RLPLVASWKTYPLFFGTAIFSFES 278

  Fly   296 IALILPLRNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEVFS 360
            |.::|||.|.|:....|.   .:|:..|...|:|:|....:.|:|:|:::..||:|||....::
Human   279 IGVVLPLENKMKNARHFP---AILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWLY- 339

  Fly   361 QVVKVIAALGVFLGYPIQFFVMIKILWP-PLKRSNNCTQKYPITSQVCLRFFMVMMTFGVALVVP 424
            |.||::...|:...|.:||:|..:|:.| .:.|   .:.::.:...:.:|..||.:|..:|:::|
Human   340 QSVKLLYIAGILCTYALQFYVPAEIIIPFAISR---VSTRWALPLDLSIRLVMVCLTCLLAILIP 401

  Fly   425 KLNLFISLIGALCSTCLAFVIPVLID---FVTRAQVPKALGVWSYIKNILILTVAVLGIVTGTYQ 486
            :|:|.|||:|::..|.||.:||.|::   |.:....|..:     .|:.||..:..:|.|.||||
Human   402 RLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPLTI-----FKDALISILGFVGFVVGTYQ 461

  Fly   487 SIVEIVK 493
            ::.|::|
Human   462 ALDELLK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	126/430 (29%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	126/427 (30%)
SLC36A2	NP_861441.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..46		3/19 (16%)
SLC36A2	NP_861441.2	SLC5-6-like_sbd	52..463	CDD:320982	126/425 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158572
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960