DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4991 and SLC38A9

DIOPT Version :9

Sequence 1:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001336311.1	Gene:	SLC38A9 / 153129	HGNCID:	26907	Length:	561	Species:	Homo sapiens

Alignment Length:	475	Identity:	97/475 - (20%)
Similarity:	168/475 - (35%)	Gaps:	170/475 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 TPGVDFLDYPETV----EKCFEHGPRPLRKMSRVMKL------------IVEMFLC--------- 185
            ||....|..|:.|    |:|:.:.|     :....||            :|.:|:.
Human    76 TPADKALIAPDHVVPAPEECYVYSP-----LGSAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSI 135

  Fly   186 ------VTQFGFCAIYFVFITENL------HQVLQQNGIVISMS--------------------- 217
                  :.|.||.....|.|...|      ::|::...::.|:.
Human   136 LSIPWGIKQAGFTTGMCVIILMGLLTLYCCYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWS 200

  Fly   218 --MVMLITLLPAMIP--SLMTNLKYISPVSLFANVALLFGLI------ATLTIAFSDGPM--PSV 270
              :..|::|:.|||.  .||:|.       ||.....:|..|      .|:....:..|:  ||.
Human   201 SLLFSLVSLIGAMIVYWVLMSNF-------LFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSA 258

  Fly   271 G-------DRHLF----TGGAQLALFFG---TALFSYEGIALILPLRNSMRRPEKFSTRFGVLNS 321
            |       ...:|    ||..|...::.   |..|...|  |:|||.| .:.|..|| :|.:|.:
Human   259 GSGGHPDNSSMIFYANDTGAQQFEKWWDKSRTVPFYLVG--LLLPLLN-FKSPSFFS-KFNILGT 319

  Fly   322 T-----MFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEV---FSQVVKVIAALGVFLGYPIQ 378
            .     :|..|...:..||.....|      .|.....|.|:   |.|:..|:.         :.
Human   320 VSVLYLIFLVTFKAVRLGFHLEFHW------FIPTEFFVPEIRFQFPQLTGVLT---------LA 369

  Fly   379 FFV---MIKILWPPLKRSNNCTQKYPITSQVCLRFFMVMMTF---GVALVV----PKLNL----- 428
            ||:   :|.:|....|:.||       ...:|:.:.:|.:|:   ||.:..    |.|:.
Human   370 FFIHNCIITLLKNNKKQENN-------VRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQ 427

  Fly   429 -FISLIGALCSTCLAFVIPV-----------LIDFVTRAQVPKALG-----VWSYIKNILILTVA 476
             |:....:  |..|:|:..:           |:.::.|.|:   ||     ::..|.::|||.:.
Human   428 NFLDNFPS--SDTLSFIARIFLLFQMMTVYPLLGYLARVQL---LGHIFGDIYPSIFHVLILNLI 487

  Fly   477 VLG---IVTGTYQSIVEIVK 493
            ::|   |:...|.:|..|::
Human   488 IVGAGVIMACFYPNIGGIIR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	95/469 (20%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	95/468 (20%)
SLC38A9	NP_001336311.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		SLC5-6-like_sbd	115..556	CDD:320982	87/431 (20%)
		Important for arginine binding and amino acid transport. /evidence=ECO:0000250\|UniProtKB:Q08BA4	129..134		0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930