Protein Alignment CG4991 and SLC38A3

DIOPT Version :10

• Sequence 1: NP_001259638.1
• Gene: CG4991 / 32695
• FlyBaseID: FBgn0030817
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_006832.1
• Gene: SLC38A3 / 10991
• HGNCID: 18044
• Length: 504
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 105/542 - (19%)
• Similarity: 186/542 - (34%)
• Gaps: 173/542 - (31%)

  Fly    55 KNPERFTKNVTEKGADPENGDPVR--------------RRGHETSELEAAT-------HLFKGSV 98
            |:.|.....:|....:....||.|              :..|.| :.|..|       :|....:
Human    17 KHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFT-DFEGKTSFGMSVFNLSNAIM 80

  Fly    99 GAGLFAMGDCFKNGGLAGATILLPIIAVMCVHCERMLIRGS----VLAVER-------TPGVDFL 152
            |:|:..:.....|.|:.....||..:|::..:...:|::.|    :.|.|:       |||
Human    81 GSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGVVGIRAYEQLGYRAFGTPG---- 141

  Fly   153 DYPETVEKCFEHGPRPLRKMSRVMKLIVEMFLCVTQFGFCAIYFVFITENLHQVLQ--------- 208
                                    ||...:.:.:...|..:.|...|...|..|:|
Human   142 ------------------------KLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKT 182

  Fly   209 ----QNG--IVISMSMVMLITLLPAMIPSLMTNLKYISPVSLFANVALLFGLIATLTIAFS-DGP 266
                .||  :||.:|:.:::.|      :||..|.|:...|.|:...::|.|||.:...|. ..|
Human   183 SDWYMNGNYLVILVSVTIILPL------ALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCP 241

  Fly   267 MP-----SVGD-RHL-----------------------FTGGAQLALFFGTALFSYEGIALILPL 302
            :|     :.|: .|:                       ||..:|.|.......|::.....:||:
Human   242 LPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPI 306

  Fly   303 RNSMRRPEK-----FSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEV---F 359
            ...::.|.|     .|.....:...|:|..|||   |::::            .|.|..|:   :
Human   307 YTELKDPSKKKMQHISNLSIAVMYIMYFLAALF---GYLTF------------YNGVESELLHTY 356

  Fly   360 SQV---------VKVIAALGVFLGYPIQFFVMIKILWPPLKRSNNCTQKYPITSQVCLRFFMVMM 415
            |:|         |:|.....|.|..||..|        |::|:   .|:....:|.......|::
Human   357 SKVDPFDVLILCVRVAVLTAVTLTVPIVLF--------PVRRA---IQQMLFPNQEFSWLRHVLI 410

  Fly   416 TFGVALVVPKLNLF-------ISLIGALCSTCLAFVIPVLIDF-------VTRAQVPKALGVWSY 466
            ..|:...:..|.:|       ..:|||..:..|.|:.|.:..|       ......||.|.:...
Human   411 AVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFA 475

  Fly   467 IKNILILTVAVLGIV----TGT 484
            :...|::|:::..|:    :||
Human   476 MLGFLLMTMSLSFIIIDWASGT 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:444915	99/501 (20%)
SLC38A3	NP_006832.1	Aa_trans	64..491	CDD:279788	94/486 (19%)