DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16700 and AVT4

DIOPT Version :9

Sequence 1:	NP_573191.1	Gene:	CG16700 / 32694	FlyBaseID:	FBgn0030816	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_014298.1	Gene:	AVT4 / 855622	SGDID:	S000005045	Length:	713	Species:	Saccharomyces cerevisiae

Alignment Length:	451	Identity:	125/451 - (27%)
Similarity:	212/451 - (47%)	Gaps:	76/451 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TSYLETIVHLFKGNIGPGLFAMGDAFKNGGLLVAPLLTVVIAVVSIHCQHVLVTCSKKMRDLKGD 118
            ||..:..:.|.|..||.|:..:.:||.||||..:..:.....:.|..|.::||         :..
Yeast   297 TSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILV---------QAK 352

  Fly   119 SVCADYAQTVEQCFENGPSKLRG-WSRTMGRLVDIF-ICVTQLGFCCIYFVFISTNLKQILQAYD 181
            |.|.      ...|.:...||.| |.    |::.:| :.:||:||...|.:|.:.|    |||:
Yeast   353 SSCG------VSSFGDIGLKLYGPWM----RIIILFSLVITQVGFSGAYMIFTAKN----LQAF- 402

  Fly   182 IDMNVHLVML----------LAFVPVLLSSLITNLKWLTPVSMFANVCMILGLAITLYYALKD-- 234
            :|...|:.:|          :.|:|:   |.|.|:..|:..|:.||..::.||.|.:.:..|.
Yeast   403 LDNVFHVGVLPLSYLMVFQTIIFIPL---SFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLF 464

  Fly   235 ----GLPEVEERALWTNGSQLALFFGTAIFAFEGIALVMPLKNAMRKPHQFERPLGVLNVGMFLV 295
                |.|.:.. ....|..:..||.||||||||||.|::|::::||.|.:|  || ||.:.:...
Yeast   465 FDLMGTPAMGV-VYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKF--PL-VLALVILTA 525

  Fly   296 SVMFMFAGSVGYMKWGEQVGGSLTLNLGDT-ILAQAVKLMVSAGVLLGYPLQFFVAIQIM----W 355
            :::|:...::||:.:|..|...:.|||..: |....::|..|..::|..|||.|.||:|:    :
Yeast   526 TILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKFF 590

  Fly   356 PNAKQM--------CGIEGRSLLGELGF---------RTFMVLVTLAIAEM-VPALGLFISLIGA 402
            |...::        ..:|.|...|:|.:         |:.:|::.::||.. ...|..|:|:||:
Yeast   591 PKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGS 655

  Fly   403 LCSTALALVFPPVIELISRSELNKGPGIWICVKNLVILVLALLGFFTGSYESLKQIVKHFG 463
            |....|..::|.::.|...| |.:..|.:...|.::..:|...|..:..|.|.:.|   ||
Yeast   656 LACIPLVYIYPSMLHLRGNS-LPETKGEFWRFKPMLDTILIFFGIASMLYTSYQSI---FG 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16700	NP_573191.1	SLC5-6-like_sbd	53..452	CDD:294310	120/438 (27%)
CG16700	NP_573191.1	SdaC	57..452	CDD:223884	118/435 (27%)
AVT4	NP_014298.1	Aa_trans	295..711	CDD:279788	123/448 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	1	0.950	-	0	Normalized mean entropy	S2463
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R126
SonicParanoid	1	1.000	-	-		X121
TreeFam	1	0.960	-	-
	11	10.800