DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16700 and slc38a2

DIOPT Version :9

Sequence 1:	NP_573191.1	Gene:	CG16700 / 32694	FlyBaseID:	FBgn0030816	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001038569.1	Gene:	slc38a2 / 566537	ZFINID:	ZDB-GENE-030131-9659	Length:	504	Species:	Danio rerio

Alignment Length:	534	Identity:	113/534 - (21%)
Similarity:	196/534 - (36%)	Gaps:	140/534 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EAPNQLEKNQTATVPRQETAEGGSTGETAVGGAAAKVTKE---------------QDH------- 46
            :||.|:.:...|  |..:::...|...|.....|:||...               .||
Zfish     3 KAPAQMSRFNIA--PDMDSSSTNSNEYTNYQDHASKVPLNGIQYSDVEAESQNFLSDHHLGKKKY 65

  Fly    47 DAEYHP-PTSYLETIVHLFKGNIGPGLFAMGDAFKNGGLLVAPLLTVVIAVVSIHCQHVLVTCSK 110
            :|||.| ..|:..::.:|....:|.|:..:..|..|.|:.:..:|.|.:|:.|::..|:|:..:.
Zfish    66 EAEYSPGSASFGMSVFNLGNAIMGSGILGLSYAMANTGIAMFVILLVAVAIFSLYSVHLLLKTAN 130

  Fly   111 KMRDLKGDSVCADYAQTVEQCFENGPSKLRGWSRTMGRLVDIFICVTQLGFCCIYFVFISTNLKQ 175
                 :|.|:.  |.|...:.| ..|.||         .....|.:...|....|...:...|..
Zfish   131 -----EGGSLV--YEQLGYKAF-GIPGKL---------AASCSITMQNFGAMASYLYIVKYELPI 178

  Fly   176 ILQAYDIDMN--------VHLVMLLAFVPVLLSSLITNLKWLTPVSMFANVCMILGLAITLY--Y 230
            :::|: :|.|        .:||:::....:|..||:.||.:|...|.|:.:||:..|.:.:|  :
Zfish   179 VIRAF-LDSNDNAWYTNGDYLVLIVTMSIILPLSLLKNLGYLGYTSGFSLLCMVFFLIVVIYKKF 242

  Fly   231 ALKDGLPE--------VEERALWTN--------------GSQLALFFGTAIFAFEGIALVMP--- 270
            .:...|||        |.:.....|              .||.........|||.....::|
Zfish   243 QIPCPLPENFINITVNVSQPPQTNNSTDEECCKPKYFIFNSQTVYAVPILTFAFVCHPAILPMYE 307

  Fly   271 -LKNAMRKPHQFERPLGVLNVGMFLVSVMFMFAGSVGYMKWGEQVGGSLTLNLG-----DTILAQ 329
             ||:..|:..|     .|.||....:.:|::.|...||:.:.|.|...|.....     |.:|.
Zfish   308 ELKDRSRRKMQ-----NVANVSFLGMFIMYLLAALFGYLTFNEAVEPELLHTYSKVYNFDVVLL- 366

  Fly   330 AVKLMVSAGVLLGYPLQFF-----------VAIQIMWPNAKQMCGIEGRSLLGELGFRTFMVLVT 383
            .|:|.|...|.|..|:..|           .:.:..||  :.:|                   :|
Zfish   367 IVRLAVLTAVTLTVPVVLFPIRTSVNHLLGASKEFSWP--RHIC-------------------IT 410

  Fly   384 LAIAEMVPALGLFI-------SLIGALCSTALALVFPPV--IELISRSELNKGPGIWICVKNLVI 439
            :|:...|..|.:|:       ..|||..:..|..:.|..  |:|:.:..:..       |:.:..
Zfish   411 VALLVCVNILVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKESMKS-------VQKIGA 468

  Fly   440 LVLALLGF--FTGS 451
            .:..::||  .|||
Zfish   469 TLFLIMGFLVMTGS 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16700	NP_573191.1	SLC5-6-like_sbd	53..452	CDD:294310	97/462 (21%)
CG16700	NP_573191.1	SdaC	57..452	CDD:223884	96/458 (21%)
slc38a2	NP_001038569.1	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..99		20/97 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		6/26 (23%)
		SdaC	70..479	CDD:223884	95/460 (21%)
		SLC5-6-like_sbd	72..488	CDD:294310	97/463 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750