DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16700 and Slc36a4

DIOPT Version :9

Sequence 1:	NP_573191.1	Gene:	CG16700 / 32694	FlyBaseID:	FBgn0030816	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_758493.2	Gene:	Slc36a4 / 234967	MGIID:	2442595	Length:	500	Species:	Mus musculus

Alignment Length:	505	Identity:	162/505 - (32%)
Similarity:	275/505 - (54%)	Gaps:	78/505 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAEAP------NQLEKNQTATVPRQETAEGGSTGE---TAVGGAAAKVTKEQDHDAEYHPPTSY 56
            |:|.||      .:|:.:....:..::..:|.|..|   |.|     .:.|....|.::  ..|:
Mouse     1 MEAPAPAETAGCEELDMDVMRPLINEQNFDGSSDEEQEQTLV-----PIQKHYQLDGQH--GISF 58

  Fly    57 LETIVHLFKGNIGPGLFAMGDAFKNGGLLVAPLLTVVIAVVSIHCQHVLVTCSKKM-RDLKGDSV 120
            |:|:|||.|||||.||..:..|.||.|:::.|:..|.|.::|:||.|:||.||..: :..|..::
Mouse    59 LQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKSTL 123

  Fly   121 CADYAQTVEQCFENGP----SKLRGWSRTMGRLVDIFICVTQLGFCCIYFVFISTNLKQILQAY- 180
              .|:.||....|..|    .:...|.|:   :||.|:.:||||||.:|.||::.|:||:.:.:
Mouse   124 --GYSDTVSFAMEASPWSCLQRQAAWGRS---VVDFFLVITQLGFCSVYIVFLAENVKQVHEGFL 183

  Fly   181 -------------------DIDMNVHLVMLLAFVP-VLLSSLITNLKWLTPVSMFANVCMILGLA 225
                               .:|:.|:   :|.|:| ::|...|..||.|..:|..||:.|...|.
Mouse   184 GSTPIVSNGSDLSHACERRSVDLRVY---MLCFLPLIILLVFIRELKNLFVLSFLANISMAASLV 245

  Fly   226 ITLYYALKDGLPEVEERALWTNGSQLALFFGTAIFAFEGIALVMPLKNAMRKPHQFERPLGVLNV 290
            |...|.::: :|:.....:.....:..||||||:||||||.:|:||:|.||:..:|.:   .||:
Mouse   246 IIYQYVVRN-MPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRFPQ---ALNI 306

  Fly   291 GMFLVSVMFMFAGSVGYMKWGEQVGGSLTLNL-GDTILAQAVKLMVSAGVLLGYPLQFFVAIQIM 354
            ||.:|:|:::...::|||.:.:::.||:|||| .|..|.|:||::.|.|:.:.|.:||:|..:|:
Mouse   307 GMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEII 371

  Fly   355 WPNA--------KQMCGIEGRSLLGELGFRTFMVLVTLAIAEMVPALGLFISLIGALCSTALALV 411
            .|..        |::|         |.|.|:.:|.:|.|.|.::|.|.:.||.:||:.|:.|||:
Mouse   372 IPGVTARLHAKWKRIC---------EFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALI 427

  Fly   412 FPPVIELI--SRSELNKGPGIWICVKNLVILVLALLGFFTGSYESLKQIV 459
            .||::|::  |:...|    ||:.:||:.|....::||..|:|.::::|:
Mouse   428 LPPLVEILTFSKDHYN----IWMILKNISIAFTGVVGFLLGTYVTVEEII 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16700	NP_573191.1	SLC5-6-like_sbd	53..452	CDD:294310	148/435 (34%)
CG16700	NP_573191.1	SdaC	57..452	CDD:223884	147/431 (34%)
Slc36a4	NP_758493.2	SLC5-6-like_sbd	54..469	CDD:294310	149/441 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D697331at2759
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R126
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850