DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and AGBL4

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_011540610.1	Gene:	AGBL4 / 84871	HGNCID:	25892	Length:	531	Species:	Homo sapiens

Alignment Length:	415	Identity:	72/415 - (17%)
Similarity:	130/415 - (31%)	Gaps:	188/415 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly  1083 PMTWNRYHNHDEIVKYLETVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIK 1147
            |.|:.|:.:      ||::::.|:........:|:|.:.|.|                 .|.||.
Human   180 PYTYTRFQH------YLDSLQKRNMDYFFREQLGQSVQQRKL-----------------DLLTIT 221

  Fly  1148 RPKRKRKSGQANAVFVEA-----------------------------GAQGLAWIGPAAATWMIA 1183
            .|...|:..:...||:..                             .:.|:.|:.|....::::
Human   222 SPDNLREGAEQKVVFITGRVHPGETPSSFVCQGIPPGHWAALSSSFQNSPGIHWMSPGIIDFLVS 286

  Fly  1184 E-----LLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQTPPPSGLL 1243
            :     :||           |::   .:.|.|:||||| .|...|.
Human   287 QHPIACVLR-----------EYL---VFKIAPMLNPDG-VYLGNYR------------------- 317

  Fly  1244 DSAMTWLQQKRGPDKVC--YGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVSEFLM 1306
                            |  .|.||:|:||                  .|:|:..|....|.:.::
Human   318 ----------------CSLMGFDLNRHWL------------------DPSPWVHPTLHGVKQLIV 348

  Fly  1307 ----DYRTQIKLYISLQAYGQVISYPVKANSTFNSERL--------------DDF--------LD 1345
                |.:|.::.||.:.|:..:::..:..|...:.||.              :||        .|
Human   349 QMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQRQAIFPKLLCQNAEDFSYSSTSFNRD 413

  Fly  1346 VAMVGTDGLRKKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLP-S 1409
            ....|| |.|..|.           |::..|.|              |||:::   .:.|::. :
Human   414 AVKAGT-GRRFLGG-----------LLDHTSYC--------------YTLEVS---FYSYIISGT 449

  Fly  1410 SAIEPTARDAF-----EIISGMLDY 1429
            :|..|...:|:     .:....|||
Human   450 TAAVPYTEEAYMKLGRNVARTFLDY 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	69/409 (17%)
AGBL4	XP_011540610.1	M14_AGBL4_like	190..475	CDD:133118	68/399 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810