DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8945 and aebp1a

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001311338.1	Gene:	aebp1a / 793308	ZFINID:	ZDB-GENE-030131-2390	Length:	1022	Species:	Danio rerio

Alignment Length:	975	Identity:	177/975 - (18%)
Similarity:	304/975 - (31%)	Gaps:	394/975 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 EMDSSRTQHRRS--RRSLYSIKNG--EIEKSIKTEKATKVPSEE-AEKEVTADSTKRSQKVVSKE 514
            |:.::..|..||  .|....:|:.  ::::....:.....|.|| |||| .....|..:::::.:
Zfish    23 ELANAPNQRTRSIQMRQSNGVKSNRDDLQEGFSEDTQMDEPGEEMAEKE-KPKGKKTPEEILAAK 86

  Fly   515 SKTILSRGNPNVVAARRVSTPKRRSPKGSSGRRKTKQQTPPSTQKKEKNSGGVLHIPTALHLLHR 579
            :|.          ||.:.:  |.:.||.:...:.||:..||...||.|
Zfish    87 AKK----------AAEKEA--KAKKPKPTKKPKPTKKPKPPKATKKSK----------------- 122

  Fly   580 NHSQDEVPKVPLNANQKKK--------RKVKERKRGRPQLPSFDIFELMSDGDYEDEGEEEEEEQ 636
                      |..|.:|.|        |:.|..|  :|.:...:...|:..|......:|.|.|:
Zfish   123 ----------PPKATKKPKAAKPTTPARETKPTK--KPTMEEEEEKLLLELGWDTLSPKETEMEK 175

  Fly   637 DDDEDYYFEDEHKDEDKNKP---------NESSSTEVGQSDL---KEDSSSAEEGADFGAMVEEE 689
            ....|:   |.|..:|...|         |..|..|:.:.||   .:..||.::.:.:..:.||.
Zfish   176 PIGPDH---DMHSKKDPTTPPSVKEHMPDNWDSRHEIQEPDLIPKVKQPSSTDDPSIYLPIPEEA 237

  Fly   690 TTTTATIS---------------SSEELDATSSTKNSMAKKKIRIKRRPVDSDEDYDDDEDSGIA 739
            |||..||:               ..|||:.....|...|:|
Zfish   238 TTTPRTIAPWYEEYDYADLAAKKQEEELEKARKAKEEKAEK------------------------ 278

  Fly   740 GFFRMIFYPVQVAMSRLMDGFGTPDEEEDK--------EPATQPVSKYPSY-----TLYHSAHSN 791
                         :.::.:     :|||:|        ||...|.....|:     .:..|:.||
Zfish   279 -------------LRKMWE-----EEEEEKRKQTALHAEPKKCPPLGLESHRVEDDQILASSSSN 325

  Fly   792 EAYA----EPDDEDSEDDEDSSSLGSWFGS------WFGLQRRTKKIGSTTTTMPVPLPPPTKAP 846
            ..|:    ..:.::|.|:||... |:|...      ||.:..|.:    ...|..:.....:::.
Zfish   326 LGYSALRGRLNMQNSADEEDVYG-GAWCADTEEKEHWFQVDGRRE----VEFTGVITQGRNSESN 385

  Fly   847 PSWLESWFGFGSTTEAD---AEDDYDKWFSSWFDSRPKRKFRRRSTTSTSTTSTTTTTHTPSAAA 908
            ..::.|:|...|....:   ..|.|.:|.  ::.:..|            .|...|....| ..|
Zfish   386 NDFVSSFFVAFSNDSREWTVLHDGYAEWL--FYGNVDK------------DTPVMTEFSYP-VVA 435

  Fly   909 AQVPILTIVDPLRNPQNWIGILAHHIVNSTGSAISTSTSNPLLQALATRMTTRGTTSTTTTTSRP 973
            ..:.:|        ||:|.|                        :|..|:...|....|:..:..
Zfish   436 RYIRVL--------PQSWNG------------------------SLCMRLEVLGCQLPTSYATEN 468

  Fly   974 DVPRRISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPSLRGLTDVLVPPKMLVDFQG 1038
            |||              |.|:
Zfish   469 DVP--------------PTDD-------------------------------------------- 475

  Fly  1039 TLNYEGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETVR 1103
             |:|                                             |:||:.|:.:.::.:.
Zfish   476 -LDY---------------------------------------------RHHNYKEMRQMMKVIN 494

  Fly  1104 MRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQ 1168
            ...|.:..:.:||:||:|..:..::|        ::|.|.|....|:.:          ..||..
Zfish   495 EECPNITRIYNIGKSFQGLKMYAMEI--------SDNPGEHEPGEPEFR----------YTAGLH 541

  Fly  1169 GLAWIGPAAATWMIAELLRLMK---TNKSNED-------VEFIRNTTWYIMPVLNPDGYAYSHEY 1223
            |...:|        .|||.|:.   ..:.|:|       ||.:|   .:::|.||||.|..::|
Zfish   542 GNEVLG--------RELLLLLMQFICKEYNDDNPRVHRLVETVR---IHLVPSLNPDAYELAYE- 594

  Fly  1224 DRFWKKSRSQHQTPPPSGLLDSAM------TWLQQ-----KRGPD--KVCYGVDLDRNWLYHWGK 1275
                               :.|.|      .|.::     :..||  .|.:|.: ||.|:.....
Zfish   595 -------------------MGSEMGNWALGHWTEEGYDIFQNFPDLNSVLWGAE-DRGWVPRIVP 639

  Fly  1276 RGSSKAPCNEFYAGPAPFSEPETKAVSEFLMDYRTQIKLYISLQAYGQVISYPV------KANST 1334
            ......|.| |..|..   ..||||:..::  .||...|..:||...::::||.      :|.||
Zfish   640 NHHIPIPEN-FLNGSV---ATETKAIISWM--ERTPFVLGANLQGGEKLVAYPFDMQRPPRATST 698

Fly 1335 1334
Zfish 699 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	4/69 (6%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	62/275 (23%)
aebp1a	NP_001311338.1	FA58C	302..458	CDD:214572	34/207 (16%)
		FA58C	304..457	CDD:238014	34/204 (17%)
		Peptidase_M14_like	476..828	CDD:299699	65/324 (20%)
		Peptidase_M14NE-CP-C_like	832..907	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5214
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050