DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and Cpa4

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_017177239.1	Gene:	Cpa4 / 71791	MGIID:	1919041	Length:	469	Species:	Mus musculus

Alignment Length:	455	Identity:	125/455 - (27%)
Similarity:	210/455 - (46%)	Gaps:	61/455 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   979 ISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPS-LRGLTDVLVPPKMLVDFQGTLNY 1042
            :.:.:.|::|:..::.:::|.|.|. ...|.:||...|.|| .....|:|||...|:..:..|..
Mouse    68 LPFSRDQVFRINVRNGDEIRKLTEL-VNSDHLKLSVWKSPSTFDRPVDILVPSVSLLPVKSFLKS 131

  Fly  1043 EGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETVRMRHP 1107
            :|:.:.|.|.|: :|:   |..||..........|   .....:..||..:.|...::::....|
Mouse   132 QGLDYSVTIEDL-QAL---LDNEDEEMQHNEGIER---SGDFNYGAYHPLEAIYHEMDSIATDFP 189

  Fly  1108 QLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQGLAW 1172
            :||..:.||.:||.||:.|:|.        :...|.   |||          |:::.||.....|
Mouse   190 ELVSRVKIGETFEKRPMYVLKF--------STGGGK---KRP----------AIWLNAGIHAREW 233

  Fly  1173 IGPAAATWMIAELLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQTP 1237
            |..|.|.|...:::...|  |.......::....:::||.|||||.|:...:|.|:|:||
Mouse   234 ISQATAIWTARKIVTDYK--KDPAITSILKKVDIFLLPVANPDGYVYTQSQNRLWRKTRS----- 291

  Fly  1238 PPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVS 1302
                            |.|...|.|.|.:|||...:...|:|..||:|.|.|..|.||.|.|:|.
Mouse   292 ----------------RNPGSRCVGADPNRNWNASFAGEGTSDNPCSEVYHGSHPNSEVEVKSVV 340

  Fly  1303 EFLMDYRTQIKLYISLQAYGQVISYP--VKANSTFNSERLDDFLDVAMVGTDGLRKKGSKSRYKV 1365
            :|:..: ...|.:|.|.:|.|::.||  .......::|.||   |||......|... |.::|:|
Mouse   341 DFIQKH-GNFKCFIDLHSYSQLLMYPYGYTVKKAPDAEELD---DVARNAAQALASL-SGTKYRV 400

  Fly  1366 DASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTARDAFEIISGMLDYI 1430
            ..:...:...||.:..: ||:.||.:::|.:|.|.|.:|:|||:|.|.|||.:.:..:..:::::
Mouse   401 GPTCTTVYPASGSSVDW-AYDNGIKYAFTFELRDTGYYGFLLPASQIIPTAEETWLGLKTIMEHV 464

Fly 1431 1430
Mouse 465 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	20/70 (29%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	99/342 (29%)
Cpa4	XP_017177239.1	Propep_M14	81..150	CDD:366995	21/73 (29%)
Cpa4	XP_017177239.1	M14_CPA	166..467	CDD:349442	99/349 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820