DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and AGBL5

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_068603.4	Gene:	AGBL5 / 60509	HGNCID:	26147	Length:	886	Species:	Homo sapiens

Alignment Length:	354	Identity:	75/354 - (21%)
Similarity:	118/354 - (33%)	Gaps:	89/354 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VPRYQHQTSIRFEPPELDFQLFDEDQDQAPSQPYVFESVEESQPGSTIFDQFHVQSELLEIKEPN 123
            :|...|.......||...|          ||: |..|..|:......|        ..|::.|.|
Human   528 IPAACHDNGRASPPPPPAF----------PSR-YTVELFEQVGRAMAI--------AALDMAECN 573

  Fly   124 P-SRKPQTKPQSAGNGTTFPIYFTHPTTGIVYAISQVGVGHNP-----------NGIPTQ-SRND 175
            | .|...::..|..|...:.:.....:.|:   .|.:.||.|.           ||:|.. |.|.
Human   574 PWPRIVLSEHSSLTNLRAWMLKHVRNSRGL---SSTLNVGVNKKRGLRTPPKSHNGLPVSCSENT 635

  Fly   176 SNAIAIYVTKAQYDADMESLRRQYEQQCLP-IP---------PGTVISTLNPVHHG-GTTARPQI 229
            .:....:.|.........|.:...:.:..| .|         ||...||....|.. |....|:.
Human   636 LSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVTHRVLGPVREPRS 700

  Fly   230 IRLKKPKNPITKPSNKLPKPNYRPPPVMVTSGPIDHVSDQLLKLPHRTGS--------TTRSTTT 286
            ...::.:.|:    |..|..:..|.|...:|||..         .|:.||        ...|:.:
Human   701 QDRRRQQQPL----NHRPAGSLAPSPAPTSSGPAS---------SHKLGSCLLPDSFNIPGSSCS 752

  Fly   287 TTSTTSRPNTRRKKRK-------KIPKNKTKVIKKRPGYGANNTRGPQGSLPIILGKRPSTTTTT 344
            ..|:..:|.......|       ::|..||: ::.||..|       :||.|...|.:.|:..|:
Human   753 LLSSGDKPEAVMVIGKGLLGTGARMPCIKTR-LQARPRLG-------RGSPPTRRGMKGSSGPTS 809

  Fly   345 TTSRPPPAYTQLE------KPHMPQATLP 367
            .|.|...: ::||      .|.:|||..|
Human   810 PTPRTRES-SELELGSCSATPGLPQARPP 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844
AGBL5	NP_068603.4	M14_AGBL5_like	176..568	CDD:199860	11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..364
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..734		28/141 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..848		18/62 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810