DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and aebp1b

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	1011	Identity:	181/1011 - (17%)
Similarity:	320/1011 - (31%)	Gaps:	354/1011 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 NVFSQHLLRSDLEPAEESETLEEQEPLQSDEQLNLRI--RRSVEDVRREKR---RGPLHAKKRN- 428
            |..::| .:|::...:..:.:|::.....::.|.::|  ..:..:|.:.|:   :....||..|
Zfish    25 NGLTEH-SKSEISHTDREQHVEDRNVTSVEDLLQVKIIPPYATIEVGQHKQLLCKVSSDAKNINW 88

  Fly   429 ---SSLKALIKKSVLKNAVKRARLLKNQGEMDSSRTQHRRSRRSLYSIKNGEIEKSIKTEKATKV 490
               :..|.|.|...||        :.|.|.:.||.|....      ::.|..|.|.:.|...|
Zfish    89 VSPNGEKVLTKHGNLK--------VHNHGSVLSSLTVLNA------NLNNAGIYKCVATNGDT-- 137

  Fly   491 PSEEAEKEVTAD-STKRSQKVVSKESKTILSRGNPNVVAARRVSTPK-RRSPKGSSGRRKTKQQT 553
               |::..|..| ..||.::...::.:            .:|:..|| .:.||.|...:|
Zfish   138 ---ESQATVKLDIILKRMRRDTDRKGR------------EKRLKEPKPSKKPKASKPTKK----- 182

  Fly   554 PPSTQKKEKNSGGVLHIPTALHLLHRNHSQDEVPKVPLNANQKKKRKVKERK---RGRPQLPSFD 615
             |.::||.|...|                           .:||.:|.:|..   ......|:..
Zfish   183 -PKSEKKGKGEKG---------------------------GKKKGKKNREESTTVATTTVAPTTT 219

  Fly   616 IFELMSDGDYEDEGEEEEEEQDDDEDYYFEDEHKDEDKNKPNESSSTEVGQSDLKEDSSSAEEGA 680
            :     ..:|| |..:.|.:|..|||:..|..........|.|.:...:  .|:  |..|..:..
Zfish   220 V-----PMEYE-EFYDPEPDQYWDEDFPAETTTVARTTTTPTEKTKDFI--PDM--DEYSQPDSY 274

  Fly   681 DFGAMVEEETTTTATISSSEELDATSSTKNSMAKKKIRIKRRPVDSDEDYDDDEDSGIAGFFRMI 745
            |....|:|.|.||:.|:.                       ||.| |:||.|
Zfish   275 DDYWKVDEPTPTTSVIAG-----------------------RPAD-DDDYWD------------- 302

  Fly   746 FYPVQVAMS-RLMDGFGTPDEEE------------DKEPATQPVSKYPSYTLYHSAHSNEAYAEP 797
                  |.| .:::....||.:|            .:|| |.|..:...|..|...|..:...|.
Zfish   303 ------ARSVEMVENLPFPDGKEISSTDNDWQYTTTEEP-TVPPFENSWYEEYEYGHEKKLEEER 360

  Fly   798 DDEDSEDDEDSSSLGSWFGSWFGLQRRTKKIGSTTTTMPVPLPPPTK------APPSWLES---- 852
            :....|.:|..             :...|::........:..|||..      .||..:||
Zfish   361 ERLRKEQEEKE-------------REERKRLEEEERERRIYRPPPRVYREPKICPPLGMESHRID 412

  Fly   853 ----------WFGFGS-----TTEADAEDDYDKWFSSWFDSRPKRKFRRRSTTSTSTTSTTTTTH 902
                      ...:||     ..:|..:|| |....:|. :.|:.|.
Zfish   413 NDQLLTSSVFQHRYGSHRARLNIQASGDDD-DMNGGAWC-ANPEEKV------------------ 457

  Fly   903 TPSAAAAQVPILTIVDPLRNPQNWIGILAHHIVNSTGSAISTSTSNPL-LQALATRMTTRGTTST 966
                                  :||.:.|..:...|| .|:....:|| ...::|........|.
Zfish   458 ----------------------HWIEVDARTLTEFTG-VITQGRDDPLESDYVSTYYVAFSNDSR 499

  Fly   967 TTTTSRPDVPRRISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPSLRGLTDVLVPPK 1031
            ..|         ..:|.|..|......::....|.:|.   :.|..::::          ::|.
Zfish   500 EWT---------FLHDGYAEWLFFGNSDKNTPVLSQFM---EPVVARYIR----------ILPQ- 541

  Fly  1032 MLVDFQGTLNYEGIAHEVLIFDVGKAIAY-----ELTKEDYLQTTRPSKPRPTAPPPMTWNRYHN 1091
               .:.||:   .:..|:|...|...::.     |:|:.|.|..|                 :||
Zfish   542 ---SWNGTM---CMRMEILGCPVQDPLSQHQSENEVTRRDNLDYT-----------------HHN 583

  Fly  1092 HDEIVKYLETVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSG 1156
            :.::.|.::::....|.:.....:|:||:|..:..::|        .:|.|:|....|:.:
Zfish   584 YLDMEKLMKSISDECPNITRFYSLGKSFKGLEIYAMEI--------TDNPGVHETGEPEFR---- 636

  Fly  1157 QANAVFVEAGAQGLAWIGPAAATWMIAELLRLMKTNKSNEDV-EFIRNTTWYIMPVLNPDGYAYS 1220
                  ..||..|...:|.......:..|.:..|  ..|..| ..:..|..:::|.:||||:..:
Zfish   637 ------YTAGYHGNEALGRELLLMFMQYLCKEYK--DGNPRVRHLVDETRIHLVPSVNPDGHVKA 693

  Fly  1221 HE-----------------YDRF----------W--------KKSRSQHQTPPPSGLLDS----- 1245
            .|                 :|.|          |        .|....|..|.|.|:|.|
Zfish   694 FEKGSELGSWTLGHWTEDGHDIFQNFPDLNNIYWDSEDKGMVPKLTPNHHIPIPEGILSSNGSIA 758

  Fly  1246 -----AMTWLQQK--------RGPDK-VCYGVDLDR 1267
                 .::|::..        :|.:| |.|..|:.|
Zfish   759 METLALISWMESHPFVLGANLQGGEKLVTYPFDMRR 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	9/69 (13%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	45/234 (19%)
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	24/109 (22%)
		IG_like	62..145	CDD:214653	22/101 (22%)
		FA58C	402..555	CDD:238014	34/224 (15%)
		FA58C	403..556	CDD:214572	34/224 (15%)
		Peptidase_M14_like	577..1036	CDD:299699	47/255 (18%)
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5214
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050