DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8945 and Cpa3

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_062173.1	Gene:	Cpa3 / 54242	RGDID:	2390	Length:	417	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	126/467 - (26%)
Similarity:	212/467 - (45%)	Gaps:	88/467 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   979 ISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQ-WLKGPSLRGLTDVLVPPKMLVDF------ 1036
            :.:|:.:::|:|.|||:|...|:...:   .::|. |...    .:.|:.|  .|.|||
  Rat    19 VQFDREKVFRVKLQDEKQASILKNLTQ---TIELDFWYPD----AIHDIAV--NMTVDFRVTEKE 74

  Fly  1037 ----QGTLNYEGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVK 1097
                |.||....:.:|:||.|:.:.|..:...::.:....            ::.:|::.::||.
  Rat    75 SQTIQSTLEQHKMDYEILINDLQEEIDKQFDVKEEIAGRH------------SYAKYNDWNKIVS 127

  Fly  1098 YLETVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVF 1162
            :.|.:..:||::|..|.||.:.|..||.|:||                      .||.|:..|:|
  Rat   128 WTEKMVEKHPEMVSRIKIGSTVEDNPLYVLKI----------------------GRKDGERKAIF 170

  Fly  1163 VEAGAQGLAWIGPAAATWMIAELLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFW 1227
            ::.|.....|:.||...|.:.:..:....||..  .:.:....:|::||.|.|||.:|...||.|
  Rat   171 MDCGIHAREWVSPAFCQWFVYQAAKSYGKNKIM--TKLLDRMNFYVLPVFNVDGYIWSWTKDRMW 233

  Fly  1228 KKSRSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAP 1292
            :|:||                     :.|:..|.|.||:||:...|....::..||...|.||||
  Rat   234 RKNRS---------------------KNPNSTCIGTDLNRNFDVSWDSSPNTDNPCLSVYRGPAP 277

  Fly  1293 FSEPETKAVSEFLMDYRTQIKLYISLQAYGQVISYP----VKANSTFNSERLDDFLDVAMVGTDG 1353
            .||.|||||:.|:..:...||.||:..:|.|::.:|    :|.....     .|.|.||.:.||.
  Rat   278 ESEKETKAVTNFIRSHLNSIKAYITFHSYSQMLLFPYGYTIKLPPNH-----QDLLKVARIATDV 337

  Fly  1354 LRKKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTARD 1418
            |..: .::||........|.:.||.:..: ||::||..::..:|.|.|..|:|||.|.|:||.::
  Rat   338 LSSR-YETRYIYGPIASTIYKTSGSSLDW-AYDLGIKHTFAFELRDKGKSGFLLPESRIKPTCKE 400

  Fly  1419 AFEIISGMLDYI 1430
            ....:..:..||
  Rat   401 TMLSVKFIAKYI 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	22/80 (28%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	100/344 (29%)
Cpa3	NP_062173.1	Propep_M14	28..102	CDD:280416	23/82 (28%)
Cpa3	NP_062173.1	Peptidase_M14_like	114..413	CDD:299699	102/363 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820