DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and Cpa4

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001102816.1	Gene:	Cpa4 / 502736	RGDID:	1563619	Length:	421	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	124/455 - (27%)
Similarity:	206/455 - (45%)	Gaps:	63/455 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   982 DKY---QIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPS-LRGLTDVLVPPKMLVDFQGTLNY 1042
            ||:   |::|:..::.:::|.|.|. ...|..||...|.|| .....|:|||...|:..:..|..
  Rat    19 DKFFGDQVFRINVRNGDEIRKLTEL-VNSDHFKLNVWKSPSTFDRPVDILVPSVSLLPVKSFLKS 82

  Fly  1043 EGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETVRMRHP 1107
            :|:.:.|.| |..:|:   |..||........:.|   .....:..||:.:.|...::::....|
  Rat    83 QGLDYSVTI-DNLQAL---LDIEDEEMQHNEGRER---SGDFNYGSYHSPEAIYHEMDSIATDFP 140

  Fly  1108 QLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQGLAW 1172
            .|...:.||.:||.||:.|:|..:          |....|||          |:::.||.....|
  Rat   141 DLASRVKIGETFEKRPMYVLKFST----------GGGGKKRP----------AIWLNAGIHAREW 185

  Fly  1173 IGPAAATWMIAELLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQTP 1237
            |..|.|.|...::  :....|.......:.....:::||.|||||.|:...:|.|:|:||
  Rat   186 ISQATAIWTARKI--VTDYQKDPAVTSILEKMDIFLLPVANPDGYVYTQNQNRLWRKTRS----- 243

  Fly  1238 PPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVS 1302
                            |.|...|.|.|.:|||...:...|:|..||:|.|.|..|.||.|.|:|.
  Rat   244 ----------------RNPGSRCIGADPNRNWNASFAGEGASNNPCSEVYHGSHPNSEVEVKSVV 292

  Fly  1303 EFLMDYRTQIKLYISLQAYGQVISYP--VKANSTFNSERLDDFLDVAMVGTDGLRKKGSKSRYKV 1365
            :|:..: ...|.:|.|.:|.|::.||  .......::|.|||....|......|    |.::|:|
  Rat   293 DFIQKH-GNFKCFIDLHSYSQLLMYPYGYSVKKAPDAEELDDVARSAAKALASL----SGTKYQV 352

  Fly  1366 DASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTARDAFEIISGMLDYI 1430
            ..:...:...||.:..: ||:.||.:::|.:|.|.|.:|:|||:|.|.|||.:.::.:..:::::
  Rat   353 GPTCTTVYPASGSSVDW-AYDNGIKYAFTFELRDTGHYGFLLPASQIIPTAEETWQGLKVIMEHV 416

Fly 1431 1430
Rat 417 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	20/70 (29%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	96/342 (28%)
Cpa4	NP_001102816.1	Propep_M14	28..99	CDD:280416	21/75 (28%)
Cpa4	NP_001102816.1	Peptidase_M14_like	117..419	CDD:299699	96/349 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820