DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and agbl5

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_017210489.1	Gene:	agbl5 / 445479	ZFINID:	ZDB-GENE-040822-29	Length:	886	Species:	Danio rerio

Alignment Length:	795	Identity:	150/795 - (18%)
Similarity:	253/795 - (31%)	Gaps:	255/795 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLIVVMVVDVVHRTGAIDFGYHPSAEESDSLVRQSWGRDLLQRRVQDRRFVPRYQHQTSIRFEP 72
            :|..|..::||...|....|.|..|..|...::.|           .|.:|:......|:.  .|
Zfish   131 ILSFVHRLLDVRGVTTYFSFCYPFSYAECQDMMLQ-----------LDHKFLSSTSTHTAC--SP 182

  Fly    73 PELDFQLFDEDQDQAPSQPYVFESVEESQPGSTIFDQFHVQS--ELLEIKEPNPSRKPQTKPQSA 135
            ||              |..|..|.:..|..|..: |...|.|  .|||.:||...:
Zfish   183 PE--------------SIYYHRELLCHSLDGHRV-DLITVSSCHGLLEEREPRLDK--------- 223

  Fly   136 GNGTTFPIYFT---HPTTG--IVYAISQVGVGHNPNGIPTQSRNDSNAIAIYVTKAQYDADMESL 195
                .||...|   |..||  :.:..|:|..|..|:...      .|....::. :|.|...::|
Zfish   224 ----LFPDLSTARSHRFTGKRVFFVSSRVHPGETPSSFV------FNGFLNFIL-SQEDPRAQTL 277

  Fly   196 RRQYEQQCLPI--PPGTV--------------ISTLNP---VHHGGTTARPQII------RLKKP 235
            ||.:..:.:|:  |.|.|              ...:||   :|.....|:..::      ||...
Zfish   278 RRMFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYVNPSPDLHPSIYGAKSLMLYHHIHNRLGHA 342

  Fly   236 KNPITKPSNKLPKPNYRPPPVMVT---------------SGPIDHVSD---QLLKLPHRTG--ST 280
            .....|.||   :.|..||....|               .||...:|:   ||.:...::|  ..
Zfish   343 SGSALKTSN---QSNTSPPVATPTERERCMNLLNEAERGEGPTFDLSEIPMQLEESWEKSGVQRE 404

  Fly   281 TRSTTTTTSTTSRPNTRRKKRKKIPKNKTKV---------IKKRPG---YGANNT---------- 323
            ...:....|..||..|.....:::|..::.|         ..|| |   ||.|.|
Zfish   405 AEHSDENESAQSRGETNSAPSEQVPPQESGVAYYIDLHGHASKR-GCFMYGNNLTEESQQVENML 468

  Fly   324 --------------------------------RGPQGSLPIILGKRPSTTTTTT----------- 345
                                            :..:||..:.:.|......:.|
Zfish   469 YAKLISLNCAHFDFLGCNFSEKNMYARDKRDGQSKEGSGRVAIHKAMGLVHSYTLECNYNTGRSV 533

  Fly   346 -------------TSRPPPAYTQLEKPHMPQATLPTSNVFSQHLLRSDLEPAEESE----TLEEQ 393
                         |..||||:.       |:.|........:.:..:.|:.||.:.    .|.|.
Zfish   534 NTIPPACHDNGRATPPPPPAFP-------PKYTPEVYEQVGRAVAVAALDMAECNPWPRLVLSEH 591

  Fly   394 EPLQSDEQLNLR------IRRSVEDVRREKRRGPLHAKKRNSSLKALIKKSVLKNAVKRARLLKN 452
            ..|     ||||      :|.|.......:|.  .|.|..:|..|..:..|..:|::.|.|...|
Zfish   592 SSL-----LNLRASILKHVRNSTGLTSNNRRN--THCKTSSSPPKPALSTSASENSLNRTRSTTN 649

  Fly   453 -QG-----EMDSS------RTQHRRSRRSLYSIKNGEIEK--------------------SIKTE 485
             ||     ::.||      .|.||.|.|||..::..:.::                    |::..
Zfish   650 VQGSRQTPQLKSSPSFTFGTTAHRPSHRSLGPVRECKAQEKRRPPPPPLPHHHHQQHQRLSVRLS 714

  Fly   486 KATKVP-SEEAEKEVTADSTKRSQKVVSKESKTILSRGNPNVVAARRVSTPKRRSPKGSSGR--- 546
            ...:.| |..:....::.|...|.......|.::.....|....|.::.  :.|..:|..||
Zfish   715 APVRAPLSPSSSSSSSSSSPSSSSSAPGPGSISLAGNSCPEFRPANQIK--ELRGGRGKGGRSGP 777

  Fly   547 ---RKTKQQTPPSTQKKEKNSGGVLHIPTALHLLHRNHSQDEVPKVPLNANQKKKRKVKERKRGR 608
               ..::|:|..:|::..::|   |.|.|::     .:|:.|:...|.....:::.:........
Zfish   778 AYCHSSQQRTALTTKEPLQDS---LDILTSI-----EYSRCELQPRPSRIPVRRELQSSVIPLSS 834

  Fly   609 PQLPSFDIFELMSDG 623
            .:.|:..:::|:..|
Zfish   835 TETPTMRVWKLIKPG 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844
agbl5	XP_017210489.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900