DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and CG12374

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	123/460 - (26%)
Similarity:	204/460 - (44%)	Gaps:	80/460 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   976 PRRIS--YDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPSLRG-LTDVLVPPKMLVDFQ 1037
            |.|::  ||.::|::|..:...|   :||.||..:.:.:.:|......| ..:|:|.|......:
  Fly    20 PGRMAARYDHFRIYQLTIETNLQ---MEELKKIHEHISVHFLNELGAVGNKYNVIVGPLFHRALE 81

  Fly  1038 GTLNYEGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETV 1102
            .||.:..|.:||::.|:.|.|......:|               ..|.|..||..|.|..:::..
  Fly    82 KTLKFLEIVYEVIVDDLQKLIDESSVGDD---------------SQMEWETYHTLDTIYDWIDQE 131

  Fly  1103 RMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGA 1167
            ...| ..:|...||:|:|||                      .||..:..::||. .|:|:|...
  Fly   132 CAAH-DFLECKVIGQSYEGR----------------------DIKSIRLSKRSGN-KAIFLEGNI 172

  Fly  1168 QGLAWIGPAAATWMIAELLRLMKTNKSNEDVEFIR---NTTWYIMPVLNPDGYAYSHEYDRFWKK 1229
            ..:.||..|..|:::.:|:       ::||.|..|   ...|.::|::||||:.|:||.:|.|:|
  Fly   173 HAMEWISSATVTFLLNQLI-------NSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRK 230

  Fly  1230 SRSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRG-SSKAPCNEFYAGPAPF 1293
            :|.      |:|.           |.....|||:|::||:.||||..| :...||:.::.|..|.
  Fly   231 NRR------PNGY-----------RNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPN 278

  Fly  1294 SEPETKAVSEFLMDYRT-QIKLYISLQAYGQVISYPVKANSTFNSERLDDFLDVAMVGTDGLRK- 1356
            :|.|..::..|:..:.. .|:.|::..||||.:..|...::|......:....:|...:|....
  Fly   279 TEVEIISLQNFVSSFEDGYIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADV 343

  Fly  1357 KGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTARDAFE 1421
            .||...|  .||..|....||.|..:|.....|||:.|::|.|.|..|:.|||:.|...   ..|
  Fly   344 YGSTFTY--GASGLLNYVVSGAAKDWAYGVKKIPFTCTVELRDKGTFGFFLPSNQITEV---GLE 403

  Fly  1422 IISGM 1426
            :.:|:
  Fly   404 VTAGL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	18/70 (26%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	96/344 (28%)
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	19/72 (26%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	96/344 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920