DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8945 and Agtpbp1

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001099570.1	Gene:	Agtpbp1 / 290986	RGDID:	1306307	Length:	1219	Species:	Rattus norvegicus

Alignment Length:	1426	Identity:	253/1426 - (17%)
Similarity:	415/1426 - (29%)	Gaps:	532/1426 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 HVSDQLLKLPHRTGSTTRSTTTTTST------TSRPNTRRKKRKKIPKNKTKVIKKRPGYGANNT 323
            ||:.::|.|......|.|..||..||      ::..||   |..:...|...::.:....|....
  Rat    40 HVTSKILHLAQSQEKTRREMTTKGSTGMEVLLSTLENT---KDLQTVLNILSILIELVSSGGGRR 101

  Fly   324 RG---PQGSLPIILGKRPSTTTTTTTSRPPPAYTQLE-----------------KPHMPQATLPT 368
            ..   .:|...|:|    ......:...||.....::                 |..:..|...|
  Rat   102 ASFLVAKGGSQILL----QLLMNASKDSPPHEEVMVQTHSILAKIGPKDKKFGVKARVNGALNIT 162

  Fly   369 SNVFSQHLLRSDLEPAEESETLEEQEPLQSDEQLNLRIRRSVEDVRREKRR---------GPLHA 424
            .|:..||.....|             .|...:.|.:....||..|...|..         ||.
  Rat   163 LNLVKQHFQNYRL-------------VLPCLQLLRVYSTNSVNSVSLGKNGVVELMFKIIGPF-- 212

  Fly   425 KKRNSSLK--ALIKKSVLKNAVKRARLLKNQGEMDSSRT----QHRRSRRSLYSIKNGEIEKSIK 483
            .|:||.|.  ||...:.|..:...||...::|.:....|    .||...|.    :|..|.|.|.
  Rat   213 SKKNSGLMKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRH----RNMLIRKGIL 273

  Fly   484 TEKATKVPSEEAEKEVTADSTKRSQKV-VSKESKTILSRGNPNVVAAR-------------RVST 534
                      ::.|.||  :.|..:|. :......||...:...:|.|             |...
  Rat   274 ----------QSLKSVT--NIKLGRKAFIDANGMRILYNTSQECLAVRTLDPLVNTSSLIMRKCF 326

  Fly   535 PKRRSPKGSSGRRKTKQQTPPSTQKKEKNSGGVLHIPTALHLLHRNHSQDEVPKVPLNANQKKKR 599
            ||.|.|                             :||.....|     .::|.:|:..
  Rat   327 PKNRLP-----------------------------LPTIKSSFH-----FQLPIIPVTG------ 351

  Fly   600 KVKERKRGRPQLPSFDIFELMSDGDYEDEGEEEEEEQDDDEDYYFEDEHKDEDKNK--PNESSST 662
            .|.:.....|::.  |:.:...|.|..|...|.|.|.:||.|..|:::..:.|.||  |.:....
  Rat   352 PVAQLYNLPPEVD--DVVDESDDNDDIDLEAENEVENEDDLDQSFKNDDIETDINKLRPQQVPGR 414

  Fly   663 EVGQ--------SDLKEDSSSAE-----------EGADFGAMVEEETTTTATISSSEELDATSST 708
            .:.:        .:|.:|....|           ||...|.:|        ..::.||:......
  Rat   415 TIEELKMYEHLFPELVDDFQDYELIAKEPKPFVFEGKVRGPIV--------VPTAGEEVPGNPGN 471

  Fly   709 KNSMAKKKIRIKRRPVDSDEDYDDDEDSGIAGFFRMIFYPVQVAMSRLMDGFGTPDEEEDKEPAT 773
                .:|...:|.:.....|:..:|.                              :..||.|..
  Rat   472 ----VRKGAAVKEKASPKGEEVKEDA------------------------------KGHDKTPPW 502

  Fly   774 QPVSKYPSYTLYHSAHSNEAYAEPDDE---DSEDDEDSSSLGSWFGSWFGLQRRTKKIGSTTTTM 835
            |...:..:....||  ||....:..|.   .|...:.::.|.:.....:||
  Rat   503 QLGGQNRAAASAHS--SNNDLVKALDRITLQSTPSQVAAGLTAGMRKDYGL-------------- 551

  Fly   836 PVPLPPPTKAPP--SWLESWFGFGST--------TEADAEDDYDKWFSSWFDSRPKRKFRRRSTT 890
            |:.:...|||.|  :...|....|.|        |..:.|||.|      |:|....:    ..:
  Rat   552 PLTVLSCTKACPHVAKCTSALFEGRTVHLGKLCCTGVETEDDED------FESHSSAE----QVS 606

  Fly   891 STSTTSTTTTTHTPSAAAAQVPILTIVDPLRNPQNWIGILAHHIVNSTGSA-------------- 941
            |...:....|.|.|.                        |...||.:|.|.
  Rat   607 SVEASDGPPTLHDPD------------------------LYIEIVKNTKSVPEYSEVAYPDYFGH 647

  Fly   942 ISTSTSNPLLQALATRMTTRGTTSTTTTTSRPDVPRRISYDKYQIWRLKPQDEEQVRALEEFKKG 1006
            |......|:|:.......|:..........:.|:..|:.||........|::.:.::...:|:.|
  Rat   648 IPPPFKEPILERPYGVQRTKIAQDIERLIHQNDIIDRVVYDLDNPNYTTPEEGDILKFNSKFESG 712

  Fly  1007 EDGVKLQWLKGPSLRGLTDVLVPPKMLVDFQGTLNYEGIAHEVLIFDVG---KAIAY-------E 1061
                        :||.:..:......|: ....:| ....|:...|:|.   ..:||       |
  Rat   713 ------------NLRKVIQIRKSEYDLI-LNSDIN-SNHYHQWFYFEVSGMRPGVAYRFNIINCE 763

  Fly  1062 LTKEDYLQTTRP--------SKPRPTAPPPMTWNR-------YHNH------------------- 1092
            .:...:....:|        ...||      .|.|       |.||
  Rat   764 KSNSQFNYGMQPLMYSVQEALNARP------WWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTI 822

  Fly  1093 ---------DEIVKY-------LETVRMRHPQLVELIH-----------IGRSFEGR--PLIVVK 1128
                     |::..:       ..|::| |.|.:|..|           :..:..|.  ||:.:
  Rat   823 TFTVVFPHKDDVCYFAYHYPYTYSTLQM-HLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTI- 885

  Fly  1129 IESKQTAAAANNDGLHTIK---RPKRKRKSGQANAVFVEAGAQGLAWIGPAAATWMIAELLRLMK 1190
                 ||...::...|..:   ||          .:|:.|....    |...|:|::...|..:.
  Rat   886 -----TAMPESSYYEHICQFRTRP----------YIFLSARVHP----GETNASWVMKGTLEYLM 931

  Fly  1191 TNKSNEDVEFIRNT-TWYIMPVLNPDGYAY-SHEYDRFWKKSRSQHQTPPP---------SGLLD 1244
            :|  :...:.:|.. .:.|:|:|||||... :|......:....|.|:|.|         .|||.
  Rat   932 SN--SPTAQSLREAYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPNPELHPTIYHAKGLLQ 994

  Fly  1245 --SAMTWLQQKRGPDKVC-------------YGVDLDRN-WLYHWGKRGSSKAPCNEFYAGPAPF 1293
              :|:     ||.|...|             ||..:... |..|     .:.|.|:
  Rat   995 YLAAV-----KRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTH-----DNAASCD--------- 1040

  Fly  1294 SEPETKAVSEFLMDYRTQIKL--YISLQAYGQVISYPVKANSTFNSERLDDFLDVAM-------- 1348
                  .|.:  |.|||..|:  :|:........|:.|: .|..::.|:..:.::.:
  Rat  1041 ------VVED--MGYRTLPKILSHIAPAFCMSSCSFVVE-KSKESTARVVVWREIGVQRSYTMES 1096

  Fly  1349 --------------VGTDGLRKKGSK-----SRYK--------------VDASNDLIEQRSGCAD 1380
                          :||..|.:.|:|     .|.|              :|..|||||  |.|
  Rat  1097 TLCGCDQGRYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYNLPSNLLDFENDLIE--SSC-- 1157

  Fly  1381 AFAAYEIGIPFSYTL-----------------------QLADNGVHGYLLPSSAIEPTARD 1418
                 ::..|.:|.|                       :||:|        :...||:|:|
  Rat  1158 -----KVTSPTTYVLDEDEPRFLEEVDYSAESNDELEVELAEN--------TGDYEPSAQD 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	10/72 (14%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	88/474 (19%)
Agtpbp1	NP_001099570.1	Pepdidase_M14_N	705..839	CDD:407865	21/153 (14%)
Agtpbp1	NP_001099570.1	M14_Nna1	862..1132	CDD:349477	59/319 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900