DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and cpa5

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_954965.1	Gene:	cpa5 / 246092	ZFINID:	ZDB-GENE-020514-1	Length:	419	Species:	Danio rerio

Alignment Length:	464	Identity:	120/464 - (25%)
Similarity:	216/464 - (46%)	Gaps:	83/464 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   980 SYDKYQIWRLKPQDEEQVRALEEF-KKGED-GVKLQWLKGPSLRGL-TDVLVPPKMLVDFQGTLN 1041
            :::..|::|:.|:||.|:..|:|. ::||. |:.: |:: |.|..| .|:.||...|...:..|.
Zfish    19 TFEGDQVFRITPKDEAQIDLLKELTEEGEHLGLSV-WME-PILESLPLDLHVPFHSLQAVRAFLA 81

  Fly  1042 YEGIAHEVLIFDVGKAIAYE-----------LTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEI 1095
            |..|.:.::|.:|.:.:..|           .:.:|::.||                 ||:.:.|
Zfish    82 YNQIPYHIMIENVQELLDDEQRDMVKYRGLARSTDDFVYTT-----------------YHDLNSI 129

  Fly  1096 VKYLETVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANA 1160
            ..:::.:...:..:|..:.||:|:|.|||.|:|.     :..||..|
Zfish   130 NSFMDMLVAENRNMVSKVVIGQSYEKRPLNVLKF-----STGANRPG------------------ 171

  Fly  1161 VFVEAGAQGLAWIGPAAATWMIAELLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDR 1225
            ::::.|.....|:..|:..|...::::....:....|:  :.:...::..|.||||:.|:|..||
Zfish   172 IWIDTGIHSREWVTQASGVWFAKKIVKDYGRDPVLTDI--LNSHDIFLEIVTNPDGFVYTHTKDR 234

  Fly  1226 FWKKSRSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGP 1290
            .|:|:|                     |..|...|.|||.:|||...:|..|||..||.|.|.||
Zfish   235 MWRKTR---------------------KPNPGSSCVGVDPNRNWDAGFGGGGSSNNPCTETYRGP 278

  Fly  1291 APFSEPETKAVSEFLMDYRTQIKLYISLQAYGQVISYPVKANSTFNSERLDDFLDVAMVGTDGLR 1355
            :..||||.||:.:|:..: .:||.::|:.:|.|::.||.....|...::. :..:||......|:
Zfish   279 SAHSEPEVKAIVDFVKSH-GKIKAFVSIHSYSQMLLYPYGYTYTAAKDKA-ELHEVARKAITSLQ 341

  Fly  1356 KKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTARDAF 1420
            .. ..:||...:....|.|.||....: .|..||.:|||.:|.|.|.:|::||::.|.|||.:.:
Zfish   342 SL-YNTRYTYGSIITTIYQASGGTIDW-TYNQGIKYSYTFELRDTGRYGFILPANQIVPTAEETW 404

  Fly  1421 EIISGMLDY 1429
            ..:..::::
Zfish   405 LALMAIMEH 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	23/72 (32%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	92/341 (27%)
cpa5	NP_954965.1	Propep_M14	27..100	CDD:280416	23/74 (31%)
cpa5	NP_954965.1	Peptidase_M14_like	118..417	CDD:299699	94/363 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820