Protein Alignment CG8945 and AGTPBP1

DIOPT Version :10

• Sequence 1: NP_573190.1
• Gene: CG8945 / 32693
• FlyBaseID: FBgn0030815
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001273644.1
• Gene: AGTPBP1 / 23287
• HGNCID: 17258
• Length: 1278
• Species: Homo sapiens
• Alignment Length: 1497
• Identity: 276/1497 - (18%)
• Similarity: 449/1497 - (29%)
• Gaps: 578/1497 - (38%)

  Fly   276 RTGSTTRS---TTTTTSTTSRPNTRRKKRKKIPKNKTKVIKKRPGY--GANNTRGPQGSLPIILG 335
            ||||...|   .....:.::.|.|  ....|.|....:.|::.||.  ||...|||:
Human     2 RTGSAASSAAAAAAAAAASASPAT--GVCMKTPGGGRRGIRRDPGAEPGAAALRGPR-------- 56

  Fly   336 KRPSTTTTTTTSRPPPAYTQLEKPHMPQATLPTSNVFSQ---HLLRSDLEPAEES---------- 387
            :||..:..|..||......||||.:...:...|:...:.   ||.:|..:...|.
Human    57 QRPILSRLTNNSRIVGLLAQLEKINAEPSESDTARYVTSKILHLAQSQEKTRREMTAKGSTGMEI 121

  Fly   388 --ETLEEQEPLQ-----------------------------SDEQLNLRIRRSVEDVRREKRRGP 421
              .|||..:.||                             |...|.|.:..|.|....|.....
Human   122 LLSTLENTKDLQTTLNILSILVELVSAGGGRRVSFLVTKGGSQILLQLLMNASKESPPHEDLMVQ 186

  Fly   422 LHA-------KKRNSSLKALIK--KSVLKNAVKRARLLKNQGEMDSSRTQHR-----------RS 466
            :|:       |.:...:||.|.  .::..|.||:.  |:|          ||           .|
Human   187 IHSILAKIGPKDKKFGVKARINGALNITLNLVKQN--LQN----------HRLVLPCLQLLRVYS 239

  Fly   467 RRSLYSI---KNGEIEKSIKTEKATKVPSEEAEKEVTADSTKRSQKVVS---------KESKT-- 517
            ..|:.|:   |||.:|...|               :....:|::..::.         .:|||
Human   240 ANSVNSVSLGKNGVVELMFK---------------IIGPFSKKNSSLIKVALDTLAALLKSKTNA 289

  Fly   518 --ILSRGNPNVV-------------------------AARRVSTPK--RRSPKGSSGRR---KTK 550
              .:.||...|:                         :.:.|:..|  |::...::|.:   .|.
Human   290 RRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTS 354

  Fly   551 QQ------------TPPSTQKK--EKNSGGVLHIPTALHLLHRNHSQDEVPKVPLNANQKKKRKV 601
            |:            |.....:|  .||.   |.:||.....|     .::|.:|:..      .|
Human   355 QECLAVRTLDPLVNTSSLIMRKCFPKNR---LPLPTIKSSFH-----FQLPVIPVTG------PV 405

  Fly   602 KERKRGRPQLPSFDIFELMSDGDYED-EGEEEEEEQDD-DEDYYFEDEHKDEDKNKPNESSSTEV 664
            .:.....|::.  |:.:...|.|..| |.|.|.|.:|| |:::..:|...|.:|.||.:.....:
Human   406 AQLYSLPPEVD--DVVDESDDNDDIDVEAENETENEDDLDQNFKNDDIETDINKLKPQQEPGRTI 468

  Fly   665 GQSDLK---------------EDSSSAE------EGADFGAMV----EEETTTTA---------- 694
              .|||               .|..|.|      ||...|.:|    .|||:..:
Human   469 --EDLKMYEHLFPELVDDFQDYDLISKEPKPFVFEGKVRGPIVVPTAGEETSGNSGNLRKVVMKE 531

  Fly   695 TISSSEELDATSSTKNSMAKKKIRIKRRPVDSDEDYDDDEDSGIAGFFRMIF-----YPVQVAMS 754
            .|||..:.....||...:||:.|:...|.:.......:...|.:.|....|.     ..:|...|
Human   532 NISSKGDEGEKKSTFMDLAKEDIKDNDRTLQQQPGDQNRTISSVHGLNNDIVKALDRITLQNIPS 596

  Fly   755 RLMDGFGTPDEEEDKEPATQPVSKYP-SYTLYHSAHSNEAYAE-------------PDDEDSEDD 805
            :...||    ..|.|:..:.|::... :....|.|.......|             .:.||.||.
Human   597 QTAPGF----TAEMKKDCSLPLTVLTCAKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDT 657

  Fly   806 EDSSSLGSWFGSWFGLQRRTKKIGSTTTTMPVPLPPPTKAPPSWLESWFGFGSTTEADAEDDYDK 870
            |.:||:                   ...::.||..|....|..::|......|..|. :|..|..
Human   658 ESNSSV-------------------EQASVEVPDGPTLHDPDLYIEIVKNTKSVPEY-SEVAYPD 702

  Fly   871 WFSSWFDSRPKRKFRRRSTTSTSTTSTTTTTHTPSAAAAQVPILTIVDPLRNP--QNWIGILAHH 933
            :|.                            |.|             .|.:.|  :...|:....
Human   703 YFG----------------------------HIP-------------PPFKEPILERPYGVQRTK 726

  Fly   934 IVNSTGSAISTSTSNPLLQALATRMTTRGTTSTTTTTSRPDVPRRISYD----KYQIWRLKPQDE 994
            |.......|..|                            |:..|:.||    .|.|    |::.
Human   727 IAQDIERLIHQS----------------------------DIIDRVVYDLDNPNYTI----PEEG 759

  Fly   995 EQVRALEEFKKGEDGVKLQWLKGPSLRGLTDVLVPPKMLVDFQGTLNYE---GIAHEVLIFDVG- 1055
            :.::...:|:.|.....:|..|.                 ::...||.:   ...|:...|:|.
Human   760 DILKFNSKFESGNLRKVIQIRKN-----------------EYDLILNSDINSNHYHQWFYFEVSG 807

  Fly  1056 --KAIAY-------ELTKEDYLQTTRP--------SKPRPTAPPPMTWNR-------YHNH---- 1092
              ..:||       |.:...:....:|        ...||      .|.|       |.||
Human   808 MRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARP------WWIRMGTDICYYKNHFSRS 866

  Fly  1093 ------------------------DEIVKY-------LETVRMRHPQLVELIH-----------I 1115
                                    |::..:       ..|::| |.|.:|..|           :
Human   867 SVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQM-HLQKLESAHNPQQIYFRKDVL 930

  Fly  1116 GRSFEGR--PLIVVKIESKQTAAAANN---DGLHTIKRPKRKRKSGQANAVFVEAGAQGLAWIGP 1175
            ..:..|.  ||:.:      ||...:|   ...|...||          .||:.|....    |.
Human   931 CETLSGNSCPLVTI------TAMPESNYYEHICHFRNRP----------YVFLSARVHP----GE 975

  Fly  1176 AAATWMIAELLRLMKTNKSNEDVEFIRNT-TWYIMPVLNPDGYAY-SHEYDRFWKKSRSQHQTPP 1238
            ..|:|::...|..:.:|  |...:.:|.: .:.|:|:|||||... :|......:....|.|:|.
Human   976 TNASWVMKGTLEYLMSN--NPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPS 1038

  Fly  1239 P---------SGLLD--SAMTWLQQKRGPDKVC-------------YGVDLDRNWLYHWGKRGSS 1279
            |         .|||.  :|:     ||.|...|             ||..: :..::|.....:|
Human  1039 PDLHPTIYHAKGLLQYLAAV-----KRLPLVYCDYHGHSRKKNVFMYGCSI-KETVWHTNDNATS 1097

  Fly  1280 KAPCNEF-------------YAGPAPFSEPETKAVSEFLMDYRTQIKLYISLQAYGQVISYPVKA 1331
               |:..             :..|| |.......|.|...:...::.::   :..|...||.:::
Human  1098 ---CDVVEDTGYRTLPKILSHIAPA-FCMSSCSFVVEKSKESTARVVVW---REIGVQRSYTMES 1155

  Fly  1332 -----------NSTFNSERLDDFLDVAMVGTDGLRKKGSKSRYK-----VDASNDLIEQRSGCAD 1380
                       .....:..|::......||...|::..|...|.     :|..|||||  |.|
Human  1156 TLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYNLPSSLLDFENDLIE--SSC-- 1216

  Fly  1381 AFAAYEIGIPFSYTL-----------------------QLADNGVHGYLLPSSAIEPTARDAFEI 1422
                 ::..|.:|.|                       :||:| |..|       ||:|::  |:
Human  1217 -----KVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAEN-VGDY-------EPSAQE--EV 1266

  Fly  1423 IS 1424
            :|
Human  1267 LS 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	PHA03175	396..>525	CDD:177551	34/193 (18%)
		Propep_M14	987..1061	CDD:460505	12/86 (14%)
		Peptidase_M14	1095..1421	CDD:459730	83/426 (19%)
AGTPBP1	NP_001273644.1	Pepdidase_M14_N	764..898	CDD:407865	21/156 (13%)
		M14_Nna1	921..1191	CDD:349477	56/304 (18%)