DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8945 and Agbl5

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_036020907.1	Gene:	Agbl5 / 231093	MGIID:	2441745	Length:	1007	Species:	Mus musculus

Alignment Length:	698	Identity:	133/698 - (19%)
Similarity:	223/698 - (31%)	Gaps:	236/698 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   821 LQRRTKKIGSTTTTMPVPLPPPTKAPPSWLESWFG----FGS-TTEADAEDDYDKWFSSWFDSRP 880
            ||||  ::.|.|...|...|   |.||...:...|    |.| |.|....   ...|||.|||..
Mouse    54 LQRR--RLVSRTRRWPAEAP---KRPPHSSQGLCGARGCFPSPTMELRCG---GLLFSSRFDSGN 110

  Fly   881 KRKFRRRSTTSTSTTSTTTTTHTPSAAAAQVP-----ILTIVDPLRNP-----QNWIGILAHHIV 935
            .....:..|.|:...........|::.:|..|     :.|..|.....     ::|.......
Mouse   111 LAHVEKVETVSSDGEGVGGVATAPASGSAASPDYEFNVWTRPDCAETEYENGNRSWFYFSVRG-- 173

  Fly   936 NSTGSAISTSTSNPLLQALATRMTTRGTTS-TTTTTSRPDVPRRISYDKYQIWRLKPQDEEQVRA 999
            .:.|..|..:..|...|   :::.::|... ..|..|||         :::..|.:|..|...:.
Mouse   174 GTPGKLIKINIMNMNKQ---SKLYSQGMAPFVRTLPSRP---------RWERIRERPTFELGSKL 226

  Fly  1000 LEEFKKGED-GVKLQWLKGPSLRGLTD---VLVPPKMLVDFQGTLNYEGIAHEVLIFDVGKAIAY 1060
            ...|.|.|: |..::.::|..|..:|:   ||......|:.:|...:....:.....|.
Mouse   227 SPCFSKPEEAGSHVESVRGRELVKMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDC------ 285

  Fly  1061 ELTKEDYLQ--TTRPSKPRPTAPPPMTWNRYHNHDEIVKY-LETVRM--------------RHPQ 1108
                :|.|.  ..|.|:...|...|:....||.  |::.| |:.:|:              |.|:
Mouse   286 ----QDLLSQLDQRFSENYSTHSSPLDSIYYHR--ELLCYSLDGLRVDLLTITSCHGLRDDREPR 344

  Fly  1109 LVELI-HIGR----SFEGRPLIVV--KIESKQTAAA-ANNDGLHTIKRPKRKRKSGQANAVFVEA 1165
            |.:|. .:|.    .|.|:.:..:  ::...:|.:: ..|..|..|.||...|
Mouse   345 LEQLFPDLGTPRPFRFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPR------------ 397

  Fly  1166 GAQGLAWIGPAAATWMIAELLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKS 1230
                             |:.||              |...:.::|:|||||....|
Mouse   398 -----------------AQTLR--------------RLFVFKLIPMLNPDGVVRGH--------- 422

  Fly  1231 RSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWL-------------------YHWGKR 1276
               ::|       ||.               ||:|:|.:|                   :|...|
Mouse   423 ---YRT-------DSR---------------GVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSR 462

  Fly  1277 GSSKAPC------------------------NEFYAGPAPFSE-----PETKAVSE-----FLMD 1307
            .::|:|.                        ||.:.|.:|..|     |||:...|     :||.
Mouse   463 LNAKSPTNQQPTLHLPPEAPLSDLEKANNLHNEAHLGQSPDGENPATWPETEPAEEKTDPVWLMP 527

  Fly  1308 Y----------------RTQIKLYISLQAYGQVISYPVKANSTFNSE--RLDDFLDVAMVGTDGL 1354
            .                .:.:..|:.|..:.......:..|| |:.|  ::::.|...::..:..
Mouse   528 QPIPELEEPAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNS-FSDESTQVENMLYPKLISLNSA 591

  Fly  1355 R------KKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQ 1396
            .      ....|:.|..|..:...::.||....:.|  .||..||||:
Mouse   592 HFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKA--SGIIHSYTLE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	15/73 (21%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	73/408 (18%)
Agbl5	XP_036020907.1	Pepdidase_M14_N	102..>214	CDD:407865	23/125 (18%)
Agbl5	XP_036020907.1	M14_AGBL5_like	304..695	CDD:349455	74/416 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900