DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and suro-1

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_492177.2	Gene:	suro-1 / 172557	WormBaseID:	WBGene00011235	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	120/515 - (23%)
Similarity:	215/515 - (41%)	Gaps:	106/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   962 GTTSTTTTTSRPDVPRRISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGP-SLRGLTD 1025
            |:...:|.....|       |||.:..:...||:.:..:::.:..:....|.:.|.| |:....|
Worm    19 GSVCCSTDVHNTD-------DKYALIHVSAHDEQSLHLIKQLQLNDFKYDLDFWKSPSSISDKAD 76

  Fly  1026 VLV----PPKMLVDFQGTLNYEGIAHEVLIFDVGKAIAYE-----------------------LT 1063
            ::|    ..:||   :..|::..:...:.:.||.|.|...                       |.
Worm    77 IMVKRGKSERML---RQILSFANVTVSMSVPDVEKLIMRNEGTTSKSHLGFGSLSKWLHDDPILD 138

  Fly  1064 KEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETVRMRHPQLVELIHIGRSFEGRPLIVVK 1128
            .|..|..|:....:....|   :..|.::.::|||:.|:...:|::.:::.||.:.||:|:..:|
Worm   139 SEPDLDLTKVGALKKAKYP---FGDYASYADMVKYMRTIEFYYPRIAKIVRIGATHEGKPIEGLK 200

  Fly  1129 IESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQGLAWIGPAAATWMIAELLRLMKTNK 1193
            |.:                     |.|.:..||:|:.......|.....|.:.|.:|  :.:..|
Worm   201 IGA---------------------RSSHKKRAVWVDGNIHAREWASSHTALYFINQL--VSEYGK 242

  Fly  1194 SNEDVEFIRNTTWYIMPVLNPDGYAYSHEYD----RFWKKSRSQHQTPPPSGLLDSAMTWLQQKR 1254
            ..:...::....:||:|.||||||.|:....    |.|:|:||.....|        ..|
Worm   243 DAQITNYVDTLDFYIVPCLNPDGYEYTRTSPIPTVRLWRKNRSPELCRP--------SLW----- 294

  Fly  1255 GPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVSEFLM--DYRTQIKLYIS 1317
            |.:|.|.||||:||:.:||.:||||..||:..|.|...||||||:||..||.  :.:.::..:::
Worm   295 GGEKCCRGVDLNRNFRFHWAERGSSYEPCSNIYHGEEVFSEPETRAVRNFLATPEMKDRVDAFVT 359

  Fly  1318 LQAYGQVISYPVKANSTFNSERLDDFLDVAMVGTDGLRKKGSK----------SRYKVDASNDLI 1372
            |.:|.|:..||.........|.:.:           |||...|          :.|::....|.:
Worm   360 LHSYAQLWIYPYSHEEQNYPEDIGE-----------LRKTARKAINRLSRVYGTNYRMGTGADTL 413

  Fly  1373 EQRSGCADAFAAYEIGIPFSYTLQLADNG--VHGYLLPSSAIEPTARDAFEIISGMLDYI 1430
            ...:|.:|.:|...:.:.:.|.::|....  .:|::|....:.|||.:.||....::|.:
Worm   414 SPAAGGSDDWAKSALNVKYVYLIELRPQMELSNGFILHKKELIPTAVETFEGFREVVDAV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	14/74 (19%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	94/358 (26%)
suro-1	NP_492177.2	Propep_M14	39..110	CDD:280416	14/73 (19%)
		M14_CP_A-B_like	161..473	CDD:199844	94/358 (26%)
		ShK	620..657	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920