DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	121/481 - (25%)
Similarity:	217/481 - (45%)	Gaps:	91/481 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   984 YQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPS-LRGLTDVLVPPKMLVDFQGTLNYEGIAH 1047
            ::::|:.|...:|:..:....:..|..:..:...|| :.|..|::|.|:....|:..|...|...
Worm    23 FKVFRVLPTTNQQLLQMIRLFETADTDRADFWHAPSVVNGTVDIMVAPEHTDQFRQYLEKHGYTF 87

  Fly  1048 EVLIFDVGKAIAYELTKEDYLQT-------------------TRPSKPRPTAPPPMTWNRYHNHD 1093
            :|.|.|:.|.:   :.||..|.|                   :|           :....|:::.
Worm    88 QVAIDDLHKLL---IEKEGNLSTHSNDDAFFLKRLHDDVGFHSR-----------LRMGEYYSYS 138

  Fly  1094 EIVKYLETVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQA 1158
            .:..:||.:....|.:.:||.:|.:.|||.::.:|. .|.|              |.:|
Worm   139 VLSTWLERIAENMPDIAKLIKVGTTIEGRDILGLKF-GKDT--------------PDKK------ 182

  Fly  1159 NAVFVEAGAQGLAWIGPAAATWMIAELLRLMKTNKSNEDVE---FIRNTTWYIMPVLNPDGYAY- 1219
             .|.::||.....|.....|::.|..::     |...||.:   ::.|...||:||||||||.|
Worm   183 -IVVIDAGIHAREWAAIHTASYFINLIV-----NGREEDPQIQNYLDNIVLYIIPVLNPDGYEYT 241

  Fly  1220 ----SHEYDRFWKKSRSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSK 1280
                ::...|.|:||||     |.:...|...         :..|.||||:||:.:.:.:.|:|:
Worm   242 RTDKTNPRARMWRKSRS-----PKACAFDGVR---------NSCCMGVDLNRNFDFRFSEIGASR 292

  Fly  1281 APCNEFYAGPAPFSEPETKAVSEFLMDYRTQIKLYISLQAYGQVISYPVKANSTFNSERLDDFLD 1345
            .||:|.|.||:.|||||:||.|:||...:.:::.||:|.:|.|:..|.........:..:::...
Worm   293 YPCSEIYHGPSAFSEPESKAYSQFLTSLKGRLEAYITLHSYSQLWIYSYSHRKFTYAPDIEETRR 357

  Fly  1346 VAMVGTDGL-RKKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLAD--NGV---HG 1404
            ||......| |..|:|  |:.....::|...||.:..:|...:.|.:|||::|..  .|:   :|
Worm   358 VAAKAVQELGRMYGTK--YRHGTGPEIIYAFSGGSTDWAKETLKIKYSYTIELRPGYEGIIEWNG 420

  Fly  1405 YLLPSSAIEPTARDAFEIISGMLDYI 1430
            ::|..:.:.|||::.:..::.:||.:
Worm   421 FVLDKNQLIPTAKETWAGVTVVLDEV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	17/70 (24%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	99/354 (28%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	15/72 (21%)
		M14_CP_A-B_like	134..446	CDD:349433	99/354 (28%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020